Search results for "801"
showing 10 items of 1684 documents
Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia
2016
Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P=2.55 × 10−11), 6p25.2 (rs73718779, SERPINB6, P=1.97 × 10−8) and 3q28 (rs9815073, LPP, P=3.62 × 10−8), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P=1.00 × 10−11) in the combined analysis. We find suggestive evidence (P<5 × 10−…
The marine activities performed within the TOMO-ETNA experiment
2016
<p>The TOMO-ETNA experiment was planned in order to obtain a detailed geological and structural model of the continental and oceanic crust beneath Mt. Etna volcano and northeastern Sicily up to the Aeolian Islands (southern Italy), by integrating data from active and passive refraction and reflection seismic methodologies, magnetic and gravity surveys. This paper focuses on the marine activities performed within the experiment, which have been carried out in the Ionian and Tyrrhenian Seas, during three multidisciplinary oceanographic cruises, involving three research vessels (“Sarmiento de Gamboa”, “Galatea” and “Aegaeo”) belonging to different countries and institutions. During the o…
Characterization of sulfhydryl oxidase from Aspergillus tubingensis
2017
Background Despite of the presence of sulfhydryl oxidases (SOXs) in the secretomes of industrially relevant organisms and their many potential applications, only few of these enzymes have been biochemically characterized. In addition, basic functions of most of the SOX enzymes reported so far are not fully understood. In particular, the physiological role of secreted fungal SOXs is unclear. Results The recently identified SOX from Aspergillus tubingensis (AtSOX) was produced, purified and characterized in the present work. AtSOX had a pH optimum of 6.5, and showed a good pH stability retaining more than 80% of the initial activity in a pH range 4-8.5 within 20 h. More than 70% of the initia…
Synthesising the shifting terminology of community health: A critiquing review of agent-based approaches
2021
The field of community health promotion encompasses a wide range of approaches, including bottom-up approaches that recognise and build on the agency and strengths of communities to define and pursue their health goals. Momentum towards agent-based approaches to community health promotion has grown in recent years, and several related but distinct conceptual and methodological bodies of work have developed largely in isolation from each other. The lack of a cohesive collection of research, practice, and policy has made it difficult to learn from the innovations, best practices, and shortcomings of these approaches, which is exacerbated by the imprecise and inconsistent use of related terms.…
Scientific Opinion on application EFSA‐GMO‐BE‐2013‐118 for authorisation of genetically modified maize MON 87427 × MON 89034 × 1507 × MON 88017 × 591…
2017
Abstract In this opinion, the GMO Panel assessed the five‐event stack maize MON 87427 × MON 89034 ×1507 × MON 88017 × 59122 and its 25 subcombinations, independently of their origin. The GMO Panel has previously assessed the five single events combined to produce this five‐event stack maize and 11 subcombinations of these events and did not identify safety concerns. No new data on the single events or their previously assessed subcombinations, leading to modification of the original conclusions were identified. The combination of the single events and of the newly expressed proteins in the five‐event stack maize did not give rise to issues – based on the molecular, agronomic/phenotypic or c…
Digital competence in teacher education: comparing national policies in Norway, Ireland and Spain
2021
This paper explores the development of policies dealing with teachers' digital competence in Norway, Ireland and Spain. Using a documentary research approach, the study analysed relevant policy documents from each country over a thirty-year period to the present day. Analysis of the documents highlights historical differences and similarities in how technology in education policies developed during that period and differences in how teacher education was addressed. Despite these differences, the analysis indicates a convergence in recent years towards a common understanding and the importance of teachers' digital competence influenced by supranational frameworks. The paper discusses the pot…
The role of emotion dysregulation in adolescents’ problematic smartphone use: A study on adolescent/parents triads
2021
Abstract The pervasive use of mobile phones among adolescents has led researchers to evaluate the role of parental characteristics in connection with their children's problematic smartphone use (PSU). The present study involved mother/father/adolescent triads and aimed to test a model examining the role of both parents' and adolescents' emotion dysregulation (ED) in predicting children's PSU. Two hundred and fifty-two adolescent (57.5% females; M age = 13.54, SD = 0.73)/mother (M age = 43.92, SD = 4.46)/father (M age = 47.60, SD = 5.10) triads provided measures of PSU and ED. Results from path model showed that, after controlling for adolescents' age and gender as well as for parents' age a…
The role of music in adolescents' mood regulation
2007
The aim of this study was the exploration and theoretical clarification of the role of music in adolescents' mood regulation. The phenomenon was approached through an inductive theory construction. The data were gathered from eight adolescents by means of group interviews and follow-up forms, and were then analysed using constructive grounded theory methods. The analysis resulted in a theoretical model, which describes mood regulation by music as a process of satisfying personal mood-related goals through various musical activities. The general nature of the mood regulation is described, the goals and strategies of mood regulation are examined, and finally the specific role of music in moo…
Experiencing Commercial Videos for Online Shopping
2018
In recent years online shopping has become a popular and convenient instrument for companies to buy and sell products. However, the design of these web-shops does not offer the rich multisensory experiences than physical retailing offers. In the paper we argue that audio-visual contents could provide dynamic multisensory information to offer more engaging experiences to the consumer, but to achieve this goal, audio-visual contents need to be adjusted to the cultural characteristics of the users. Despite controversies regarding universalism of the emotional experiences induced by perceptual processes, we present evidence that suggests cultural modulations of videos experiences. In the report…
Violence, War, and Gender: Collective Memory and Politics of Remembrance in Kosovo
2020
This chapter examines the politics memory and remembrance by focusing on the perceptions of citizens regarding the framework of Europeanisation and dealing with the troubled past. Although Kosovo signed the Stabilisation and Accession Agreement (SAA) with the EU, the country struggles to deal with its past in the framework of EU integration. This chapter examines the extent to which Europeanisation acts as a tool for dealing with the troubled past, or is just a superficial framework imposed from top-down policies of the EU. From six focus groups with 51 participants, both men and women and representing the main ethnic communities in Kosovo, we examine three main frameworks in the narratives…