Search results for "81"

Sleepless in Carver Country: Insomnia and Existential Crisis in Raymond Carver’s Short Fiction

2020

Chez Raymond Carver, la nuit n’est jamais uniquement une toile de fond réaliste. Dans ses nouvelles se déroulant après la tombée de la nuit, Carver joue à déconstruire les clichés généralement associés au confort de l’intimité nocturne et du lit conjugal. L’insomnie qui frappe certains de ses personnages les renvoie au contraire à leur complète solitude et à leur condition de mortels. Cet article cherche donc à voir comment la nuit blanche carvérienne est utilisée métaphoriquement pour exprimer l’angoisse de personnages souvent peu expansifs, qui veulent leur part du Rêve américain mais se retrouvent pris au piège d’un cauchemar existentiel. In Raymond Carver’s short fiction, the night is n…

Blood Flow Restriction Exercise: Considerations of Methodology, Application, and Safety

2020

Improving the Downwind Sail Design Process by Means of a Novel FSI Approach

2021

The process of designing a sail can be a challenging task because of the difficulties in predicting the real aerodynamic performance. This is especially true in the case of downwind sails, where the evaluation of the real shapes and aerodynamic forces can be very complex because of turbulent and detached flows and the high-deformable behavior of structures. Of course, numerical methods are very useful and reliable tools to investigate sail performances, and their use, also as a result of the exponential growth of computational resources at a very low cost, is spreading more and more, even in not highly competitive fields. This paper presents a new methodology to support sail designers in ev…

Brief an Johann Gottfried Herder

1797

The Role of the Skeletal Muscle Secretome in Mediating Endurance and Resistance Training Adaptations

2021

Exercise, in the form of endurance or resistance training, leads to specific molecular and cellular adaptions not only in skeletal muscles, but also in many other organs such as the brain, liver, fat or bone. In addition to direct effects of exercise on these organs, the production and release of a plethora of different signaling molecules from skeletal muscle are a centerpiece of systemic plasticity. Most studies have so far focused on the regulation and function of such myokines in acute exercise bouts. In contrast, the secretome of long-term training adaptation remains less well understood, and the contribution of non-myokine factors, including metabolites, enzymes, microRNAs or mitochon…

First Evidence of Contourite Drifts in the North-Western Sicilian Active Continental Margin (Southern Tyrrhenian Sea)

2021

We present the results of an integrated geomorphological and seismo-stratigraphic study based on high resolution marine data acquired in the north-western Sicilian continental margin. We document for the first time five contourite drifts (marked as EM1a, EM2b, EM2, EM3a, and EM3b), located in the continental slope at depths between ca. 400 and 1500 m. EM1a,b have been interpreted as elongated mounded drifts. EM1a,b are ca. 3 km long, 1.3 km wide, and have a maximum thickness of 36 m in their center that thins northwards, while EM1b is smaller with a thickness up to 24 m. They are internally characterized by mounded seismic packages dominated by continuous and parallel reflectors. EM2 is loc…

Real-world experience with dupilumab in severe asthma: One-year data from an italian named patient program

2021

Raffaele Campisi,1 Claudia Crimi,1 Santi Nolasco,2 Bianca Beghè,3 Leonardo Antonicelli,4 Gabriella Guarnieri,5 Nicola Scichilone,6 Morena Porto,2 Luigi Macchia,7 Giulia Scioscia,8 Maria Pia Foschino Barbaro,8 Alberto Papi,9 Nunzio Crimi1,2 1Respiratory Medicine Unit, A.O.U. Policlinico “G. Rodolico -San Marco”, Catania, Italy; 2Department of Clinical and Experimental Medicine, Section of Respiratory Diseases, University of Catania, Catania, Italy; 3Respiratory Medicine Unit, Department of Medicine, University of Modena and Reggio Emilia, Modena, Italy; 4Allergy Unit, Department of Internal Medicine, Ancona University Hospital, Ancona, Italy; 5Department of Car…

Sex Differences in the Physiological Network of Healthy Young Subjects

2021

Within human physiology, systemic interactions couple physiological variables to maintain homeostasis. These interactions change according to health status and are modified by factors such as age and sex. For several physiological processes, sex-based distinctions in normal physiology are present and defined in isolation. However, new methodologies are indispensable to analyze system-wide properties and interactions with the objective of exploring differences between sexes. Here we propose a new method to construct complex inferential networks from a normalization using the clinical criteria for health of physiological variables, and the correlations between anthropometric and blood tests b…

Niche position drives interspecific variation in occupancy and abundance in a highly-connected lake system

2019

Highlights • We studied interspecific variation in occupancy and abundance of freshwater species. • Occupancy and abundance correlated positively for both diatoms and macroinvertebrates. • Niche position had clearest effects on variation in occupancy and abundance. • The more marginal the niche position, the rarer a species is. We examined how niche position, niche breadth, biological traits and taxonomic relatedness affect interspecific variation in occupancy and abundance of two commonly-used biological indicator groups, i.e. diatoms and macroinvertebrates. We studied 291 diatom and 103 macroinvertebrate species that occupied the littoral zones of a large (305 km2) highly-connected freshw…

Developments in the biomechanics and equipment of Olympic cross-country skiers

2018

Source at: http://doi.org/10.3389/fphys.2018.00976 Here, our aim was to describe the major changes in cross-country (XC) skiing in recent decades, as well as potential future developments. XC skiing has been an Olympic event since the very first Winter Games in Chamonix, France, in 1924. Over the past decades, considerable developments in skiing techniques and improvements in equipment and track preparation have increased skiing speed. In contrast to the numerous investigations on the physiological determinants of successful performance, key biomechanical factors have been less explored. Today’s XC skier must master a wide range of speeds, terrains, and race distances and formats (e.g., dis…