Search results for "83"
showing 10 items of 1276 documents
Inhibition Mechanism of SARS‐CoV‐2 Main Protease with Ketone‐Based Inhibitors Unveiled by Multiscale Simulations: Insights for Improved Designs**
2021
Abstract We present the results of classical and QM/MM simulations for the inhibition of SARS‐CoV‐2 3CL protease by a hydroxymethylketone inhibitor, PF‐00835231. In the noncovalent complex the carbonyl oxygen atom of the warhead is placed in the oxyanion hole formed by residues 143 to 145, while P1–P3 groups are accommodated in the active site with interactions similar to those observed for the peptide substrate. According to alchemical free energy calculations, the P1′ hydroxymethyl group also contributes to the binding free energy. Covalent inhibition of the enzyme is triggered by the proton transfer from Cys145 to His41. This step is followed by the nucleophilic attack of the Sγ atom on …
Bibliometric Analysis of Fitness Equipment: How Scientific Focuses Affect Life-Cycle Approaches and Sustainable Ways of Development
2019
Research Question: Although fitness equipment is recognised worldwide as a tool for physical activities and a sustainable result in optimizing human movements within a wide range of environments, the state of the art and scientific advances have not been analysed from a bibliometric point of view. Research Methods: Using descriptive bibliometric software, this study examined the scientific production, and the most prolific authors, articles, and institutions. Bibliometric maps were used to visualise the content of published articles and to determine the most prolific terms, co-citation, and co-authorship. Results and Findings: A total of 678 original papers were retrieved from 447 journals …
The Common Good Balance Sheet, an Adequate Tool to Capture Non-Financials?
2019
In relation to organizational performance measurement, there is a growing concern about the creation of value for people, society and the environment. The traditional corporate reporting does not adequately satisfy the information needs of stakeholders for assessing an organization&rsquo
Corporate Sustainability and Intangible Resources Binomial: New Proposal on Intangible Resources Recognition and Evaluation
2020
This study argues that the context in which an organization adopts the principles of corporate sustainability and is guided by a culture of sustainability will determine the development of the components of corporate intangible resources. However, in trying to evaluate the impact of adopting the principles of corporate sustainability on the development of the intangible resources held by a company, we encountered a major problem, namely that there is no consistent and internationally accepted methodology for assessing such resources, despite theorists&rsquo
The Influence of the Circular Economy: Exploring the Knowledge Base
2019
The objective of this study is to analyze the main factors influencing research on theconcept of &lsquo
Human Resources Management Practices Perception and Extra-Role Behaviors: The Role of Employability and Learning at Work
2021
Human Resource Management (HRM) processes are considered the beating heart of any successful organization. Recently, several studies have highlighted how organizations can use commitment-oriented HR practices to generate organizational and individual effectiveness. The aim of this study was to verify whether the perception of HRM practices could be able to elicit extra-role behaviors and, at the same time, whether this relationship could be mediated by employability and learning conditions. The analyses were carried out on a sample of 1219 Italian workers using Structural Equation Models. The structural model yielded good fit indices and the results showed a significant and positive effect …
High-commitment work practices and the social responsibility issue: interaction and benefits
2021
Human Resource Management (HRM) has a potentially vital role to play in addressing the new challenges that companies have to face and in delivering initiatives in the framework of corporate sustainability. Our work attempts to shed light on the strategic role of High-Commitment Work Practices (HCWP) as a Corporate Sustainability (CS) partner and, more specifically, to analyze the implications of their integration on the competitiveness of the firm. With this purpose, we apply a qualitative methodology, using a single case study, to explore and explain why and how the interaction between HCWP and CS takes place. The results show how this interaction encourages the formulation and implementat…
Teacher education programmes in physical education and sport at master’s level: Opportunities and challenges
2021
I denne artikkelen undersøker vi fremtidige muligheter og utfordringer i femårige lærerutdanninger i kroppsøving og idrettsfag på masternivået, i lys av kvalitet og relevans for fagfeltet. I undersøkelsen ble det benyttet en kvalitativ tilnærming med to metodiske innganger. Først ble et utvalg på 96 masteroppgaver i perioden 2015–2018 innenfor fagfeltet kroppsøving og idrettsfag brukt for å undersøke hva slags tematikker, teoretiske tilnærminger og metoder som er benyttet i masteroppgavene. Med bakgrunn i denne undersøkelsen ble det gjennomført en workshop med et utvalg lærerutdannere for å få innsikt i hva de oppfattet som fremtidige muligheter og utfordringer i femårig lærerutdanning i fa…
Zvaigžņotā Debess: 2005, Vasara
2005
Contents: In memoriam Arturs Balklavs-Grīnhofs ; Parting Words to Arturs Balklavs ; List of Publications by Prof. Dr.phys. Arturs Balklavs-Grīnhofs ; Astronomy in 25 Years of Soviet Latvia ; Man in Space: Based on newspaper “Pravda” materials ; U.Dzērvītis. Centenary of the Theory of Relativity ; A.Balklavs. Gamma Emission from the Galactic Centre ; A.Alksnis, Z.Alksne. Fewer Brown Dwarfs, More Red Ones ; A.Alksnis. New Observations of the Eruptive Variable Star V838 Mon ; A.Balklavs. Cosmic Objects in Captivating Photos – 5 ; J. Freimanis. On Polarization of Continuous Solar Spectrum ; J.Jaunbergs. The Very First Contact with Titan ; A.Millers. Biological Effects of Cosmic Rays ; J.Jansons…
Riga devicta ab augustissimo principe Gvstavo Adolpho Svecorvm, Gothorvm, Vandalorvmqve rege, magno principe Finlandiae, duce Esthoniae, Careliaque, …
1625
Saturs:Apsveikuma dzejolis: Illustri ac generoso Domino Iacobo de la Gardie [..] Rigensis Gubernatori &c. post devictam Derpatum, plurimasque arces Livoniae, filiola divinitus orbato [39.-40.] lpp. (Grāfam Jakobam Delagardijam Zviedrijas militārajam un valsts darbiniekam, feldmaršalam (1620), Zviedru Vidzemes ģenerālgubernatoram (1621–1628)). Izdevums pieejams arī: https://digital.slub-dresden.de/werkansicht/dlf/20246/