Search results for "85"

showing 10 items of 1612 documents

Convolutional architectures for virtual screening

2020

Abstract Background A Virtual Screening algorithm has to adapt to the different stages of this process. Early screening needs to ensure that all bioactive compounds are ranked in the first positions despite of the number of false positives, while a second screening round is aimed at increasing the prediction accuracy. Results A novel CNN architecture is presented to this aim, which predicts bioactivity of candidate compounds on CDK1 using a combination of molecular fingerprints as their vector representation, and has been trained suitably to achieve good results as regards both enrichment factor and accuracy in different screening modes (98.55% accuracy in active-only selection, and 98.88% …

Virtual screeningComputer sciencelcsh:Computer applications to medicine. Medical informaticsMachine learningcomputer.software_genre01 natural sciencesBiochemistryDrug design03 medical and health sciencesUser-Computer InterfaceStructural Biology0103 physical sciencesRepresentation (mathematics)lcsh:QH301-705.5Molecular BiologyBioactivity predictionSelection (genetic algorithm)030304 developmental biologySettore ING-INF/05 - Sistemi Di Elaborazione Delle Informazioni0303 health sciencesVirtual screening010304 chemical physicsbusiness.industryApplied MathematicsResearchProcess (computing)Deep learningComputer Science Applicationslcsh:Biology (General)Molecular fingerprintslcsh:R858-859.7Artificial intelligenceDNA microarraybusinesscomputerAlgorithmsBMC Bioinformatics
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Evaluating the Effect of Stimuli Color and Frequency on SSVEP

2020

Brain&ndash

Visual perceptionBrain-Computer InterfaceFrequency bandSpeech recognitionbiomedical signal processingLow frequencyStimulus (physiology)Electroencephalographylcsh:Chemical technology01 natural sciencesBiochemistryRed ColorArticleAnalytical Chemistry03 medical and health sciences0302 clinical medicineContinuous performance taskmedicinelcsh:TP1-1185Electrical and Electronic EngineeringInstrumentationSSVEPBrain–computer interfaceMathematicsmedicine.diagnostic_test010401 analytical chemistrybrain–computer interfaceAtomic and Molecular Physics and Optics0104 chemical sciences030217 neurology & neurosurgeryelectroencephalographySensors
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Diffuse soil CO2 degassing from Linosa island

2014

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Volcano monitoringLineamentGeochemistrysoil degassingfluid geochemistryCO2lcsh:QC851-999Instruments and techniques; Soil degassing; Volcano monitoring; GeophysicsSequential Gaussian simulationSoil co2 fluxFlux (metallurgy)Soil degassingGeomorphologygeographygeography.geographical_feature_categoryRiftlcsh:QC801-809Instruments and techniquesSettore GEO/08 - Geochimica E VulcanologiaTectonicslcsh:Geophysics. Cosmic physicsGeophysicsVolcanoLinosaSoil CO_2 fluxlcsh:Meteorology. ClimatologyGeologyChannel (geography)
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Pētera Šmita sarakste ar latviešu un lietuviešu filologu, etnogrāfu Eduardu Volteri

1915

Vēstulē P. Šmits skaidro jēdzienu "krusta priedes", kā arī piemin E. Voltera pārizdoto veco Katehismu (Латышскій катехизисъ 1585 года / переизданный Э.А. Вольтеромъ. Петроградъ : тип. Акад. наук, 1915)ю

Volteris Eduardas (1856-1941)Volters Eduards (1856-1941):HUMANITIES and RELIGION [Research Subject Categories]Šmits PēterisШмидт Петр ПетровичfolkloraВольтер Эдуард Александрович (1856-1941)Endzelīns JānisЭндзелин Ян
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Continuous SO2 flux measurements for Vulcano Island, Italy

2012

<p>The La Fossa cone of Vulcano Island (Aeolian Archipelago, Italy) is a closed conduit volcano. Today, Vulcano Island is characterized by sulfataric activity, with a large fumarolic field that is mainly located in the summit area. A scanning differential optical absorption spectroscopy instrument designed by the Optical Sensing Group of Chalmers University of Technology in Göteborg, Sweden, was installed in the framework of the European project "Network for Observation of Volcanic and Atmospheric Change", in March 2008. This study presents the first dataset of SO<sub>2</sub> plume fluxes recorded for a closed volcanic system. Between 2008 and 2010, the SO<sub>2</…

Vulcano Islanddata setSO2lcsh:QC851-999fumaroleNetwork for Observation of Volcanic and Atmospheric ChangeVulcanoFlux (metallurgy)Optical sensingemissionsulfur dioxideSicilyGeomorphologyAeolian archipelagoLipari Islandvolcanology Fossa Cratergeographygeography.geographical_feature_categoryplumeDifferential optical absorption spectroscopylcsh:QC801-809Atmospheric changedegassingSettore GEO/08 - Geochimica E VulcanologiaPlumelcsh:Geophysics. Cosmic physicsGeophysicsOceanographyDifferential optical absorption spectroscopyItalyVolcanoMessina [Sicily]lcsh:Meteorology. ClimatologyGeologyAnnals of Geophysics
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MORA, Albert (dir.); DE LUCAS, Javier; GONZÁLEZ, Mª Eugenia; SOLANES, Ángeles; VÁZQUEZ, Ana Isabel (2017): Informe jurídico-social sobre la situación…

2019

VÁZQUEZGONZÁLEZ1137-7038 8537 Arxius de sociologia 525290 2019 40 7038149 MORAMª Eugenia:SOCIOLOGÍA [UNESCO]Javier2017 Caturla BastitUniversitat de ValènciaSOLANESÁngelesInforme jurídico-social sobre la situación de las personas inmigrantes en la Comunitat Valenciana. Instituto de Derechos Humanos [Ana Isabel (2017)]DE LUCASUNESCO::SOCIOLOGÍAMª del Mar 151 154Ana Isabel (2017): Informe jurídico-social sobre la situación de las personas inmigrantes en la Comunitat Valenciana. Instituto de Derechos HumanosAlbert (dir.)
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Birth weight, cardiometabolic risk factors and effect modification of physical activity in children and adolescents: pooled data from 12 internationa…

2020

Abstract Objectives Low and high birth weight is associated with higher levels of cardiometabolic risk factors and adiposity in children and adolescents, and increases the risk of cardiovascular diseases, obesity, and early mortality later in life. Moderate-to-vigorous physical activity (MVPA) is associated with lower cardiometabolic risk factors and may mitigate the detrimental consequences of high or low birth weight. Thus, we examined whether MVPA modified the associations between birth weight and cardiometabolic risk factors in children and adolescents. Methods We used pooled individual data from 12 cohort- or cross-sectional studies including 9,100 children and adolescents. Birth weigh…

WaistAdolescentEpidemiologyEndocrinology Diabetes and MetabolismBirth weightMedicine (miscellaneous)Blood Pressure610 Medicine & health030209 endocrinology & metabolism03 medical and health sciences0302 clinical medicinemedicineBirth WeightHumans030212 general & internal medicineChildExerciseTriglyceridesAdiposityCardiometabolic riskNutrition and DieteticsNorwaybusiness.industryCholesterol HDLarticleCardiometabolic Risk FactorsPaediatrics2701 Medicine (miscellaneous)10060 Epidemiology Biostatistics and Prevention Institute (EBPI)medicine.diseaseVDP::Medisinske Fag: 700::Idrettsmedisinske fag: 850/692/700/478/174ObesityPeer review2712 Endocrinology Diabetes and MetabolismLow birth weightBlood pressureRisk factorsCohort2916 Nutrition and Dietetics/692/700/1720Waist Circumferencemedicine.symptombusinesshuman activities/692/499Demography
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Water stable isotope data set in temperate, lowland catchment, two years of monthly observations, River Salaca, Latvia

2020

Highlights • Two years of monthly water stable isotope ratios from temperate lowland catchment. • Hourly water table, temperature and electrical conductivity monitoring. • Distinct isotope ratios for raised bog, groundwater and rivers.

Water tableEvaporationDrainage basinWater stable isotopesHydrogeologyGroundwater-surface water interactionlcsh:Computer applications to medicine. Medical informaticsCatchment03 medical and health sciences0302 clinical medicineparasitic diseasesTemperate climatePrecipitationlcsh:Science (General)030304 developmental biologyHydrology0303 health sciencesgeographyMultidisciplinarygeography.geographical_feature_categoryStable isotope ratioIsotope hydrologylcsh:R858-859.7Environmental scienceEarth and Planetary ScienceSurface water030217 neurology & neurosurgeryGroundwaterlcsh:Q1-390Data in Brief
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FluDetWeb: an interactive web-based system for the early detection of the onset of influenza epidemics

2009

Abstract Background The early identification of influenza outbreaks has became a priority in public health practice. A large variety of statistical algorithms for the automated monitoring of influenza surveillance have been proposed, but most of them require not only a lot of computational effort but also operation of sometimes not-so-friendly software. Results In this paper, we introduce FluDetWeb, an implementation of a prospective influenza surveillance methodology based on a client-server architecture with a thin (web-based) client application design. Users can introduce and edit their own data consisting of a series of weekly influenza incidence rates. The system returns the probabilit…

Web serverComputer sciencePosterior probabilityHealth Informaticscomputer.software_genrelcsh:Computer applications to medicine. Medical informaticsHealth informaticsDisease OutbreaksWorld Wide WebUser-Computer InterfaceSoftwareComputer SystemsInfluenza HumanHumansWeb applicationInternetbusiness.industryHealth PolicyUsabilityUnited StatesComputer Science ApplicationsIdentification (information)Population Surveillancelcsh:R858-859.7The InternetSoftware engineeringbusinesscomputerSoftwareBMC Medical Informatics and Decision Making
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Ethnographic context and spatial coherence of climate indicators for farming communities : a multi-regional comparative assessment

2015

Accurate seasonal predictions of rainfall may reduce climatic risks that farmers are usually faced with across the tropical and subtropical zones. However, although regional-scale seasonal amounts have regularly been forecasted since 1997/98, the practical use of these seasonal predictions is still limited by myriad factors. This paper synthesizes the main resultsof a multi-disciplinary ethnographic and climatic project (PICREVAT). Its main objective was to seek the climatic information ? beyond the seasonal amounts ? critical for crops, both as an actual constraint to crop yields and as identified by the current and past practices and perceptions of farmers. A second goal was to confront t…

Wet seasonAtmospheric ScienceP40 - Météorologie et climatologieCash cropGeography Planning and DevelopmentVulnerabilityContext (language use)SubtropicsSeasonal prediction;Tropical rainfall;Regional scale;Crop systems;Vulnerability;EthnoclimatologyManagement Monitoring Policy and Lawlcsh:QC851-999//purl.org/becyt/ford/5.4 [https]REGIONAL SCALECropCIENCIAS SOCIALESOtras SociologíaRegional scaleTropical rainfall2. Zero hungerClimatologyGlobal and Planetary Change//purl.org/becyt/ford/5 [https]business.industryAgroforestryCrop yieldSEASONAL PREDICTIONEnvironmental and SocietyTROPICAL RAINFALLA01 - Agriculture - Considérations générales15. Life on land[SDE.ES]Environmental Sciences/Environmental and SocietyEthnoclimatologyGeography13. Climate actionAgriculture[SDU.STU.CL]Sciences of the Universe [physics]/Earth Sciences/ClimatologyCrop systemslcsh:Meteorology. ClimatologyClimatologieMonocultureEnvironnement et SociétéSeasonal predictionbusinessCROP SYSTEMSSociología
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