Search results for "8b"

Who is more likely to respond to dual treatment with pegylated-interferon and ribavirin for chronic hepatitis C? A gender-oriented analysis.

2013

Summary We assessed, in real-life practice, viral, demographic, genetic and metabolic factors influencing the sustained virologic response (SVR), with a gender-oriented analysis, in patients with chronic hepatitis C virus (HCV) treated with pegylated interferon and ribavirin. Six hundred and seventy naive patients were treated with dual therapy and evaluated by gender and HCV genotype. Associations between baseline variables and SVR were assessed by multivariate logistic regression analysis. Among 362 genotype 1 patients, SVR was achieved in 158 patients (44%), and SVR was independently associated with age less than 50 years (OR 2.12; 95% CI 1.09–4.30; P = 0.039) and C/C genotype rs12979860…

Identification of Naïve Hcv-1 Patients with Chronic Hepatitis who may Benefit from Dual Therapy with Peg-Interferon and Ribavirin.

2014

Background & Aims The pool of HCV genotype 1 patients likely to be cured by peg-interferon and ribavirin remains to be quantified. Methods In 1045 patients treated with peg-interferon and ribavirin, two therapeutic strategies were confronted: the first one evaluated only baseline variables associated with sustained virological response (SVR), and the second one included the rapid virologic response (RVR) in addition to baseline predictors. An 80% SVR rate was the threshold to retain a strategy as clinically relevant. Results Overall, 414 patients (39.6%) attained SVR. In the first strategy, the hierarchy of features independently associated with SVR was IL28B CC genotype (OR 5.082; CI 3.637…

Variation in genes encoding for interferon λ-3 and λ-4 in the prediction of HCV-1 treatment-induced viral clearance

2013

Background & Aims In patients with chronic HCV-1 infection, recent evidences indicate that determination of a dinucleotide polymorphism (ss469415590, ΔG/TT) of a new gene, designated IFN λ-4, might be more accurate than the 12979860CC type of the IL28B locus in predicting sustained virological response (SVR) following peg-interferon and ribavirin. In addition, combined genotyping of different SNPs of the IL28B locus was shown to help dissect patients most prone to SVR among those with rs12979860CT. We examined whether single or combined genotyping of two IL28B SNPs, rs12979860 and rs8099917, and ss469415590 variation might improve the prediction of SVR. Results In the study cohort of 539 pa…

Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways.

2021

Treatment of β-lactamase positive bacterial infections with a combination of amoxicillin (AMOX) and clavulanic acid (CLAV) causes idiosyncratic drug-induced liver injury (iDILI) in a relevant number of patients, often with features of intrahepatic cholestasis. This study aims to determine serum bile acid (BA) levels in amoxicillin/clavulanate (A + C)-iDILI patients and to investigate the mechanism of cholestasis by A + C in human in vitro hepatic models. In six A + C-iDILI patients, significant elevations of serum primary conjugated BA definitely demonstrated A + C-induced cholestasis. In cultured human Upcyte hepatocytes and HepG2 cells, CLAV was more cytotoxic than AMOX, and, at subcytoto…

CXCR2 blockade impairs angiotensin II-induced CC chemokine synthesis and mononuclear leukocyte infiltration.

2007

Objective—Angiotensin II (Ang-II) and mononuclear leukocytes are involved in atherosclerosis. This study reports the inhibition of Ang-II–induced mononuclear cell recruitment by CXCR2 antagonism and the mechanisms involved.Methods and Results—Ang-II (1 nmol/L, i.p. in rats) induced CXC and CC chemokines, followed by neutrophil and mononuclear cell recruitment. Administration of the CXCR2 antagonist, SB-517785-M, inhibited the infiltration of both neutrophils (98%) and mononuclear cells (60%). SB-517785-M had no effect on the increase in CXC chemokine levels but reduced MCP-1, RANTES, and MIP-1α release by 66%, 63%, and 80%, respectively. Intravital microscopy showed that pretreatment with S…

Genomic medicine reaches HCV-related liver transplantation: Hopes and clinical and public health implications

2011

Zvaigžņotā Debess: 2010, Rudens (209)

2010

Contents: G.Carevsky, I.Daube. Comet Bennett ; E.Fogels. Srinivasa Ramanujan ; M.Krastiņš. Smallest Planet of the Solar System: a Riddle of Centuries (1st part) ; A.Alksnis, Z.Alksne. Hot Jupiters and Their Retrograde Motion ; V.Karitāns. James Webb Space Telescope. What will it Be? ; K.Salmiņš. GFZ CHAMP Laser Tracking Award to SLR Station Riga ; J.Jansons. Vladimir Afanasjev, Officer of the Baikonur Cosmodrom in the 1970s (concluded) ; J.Limansky. International Year of Astronomy 2009 in Philately. Series EUROPA (2nd sequel) ; J.Dambītis. Centenary of Prominent Latvian Mathematician Ernests Fogels (1910-1985) ; J.Klētnieks. Sketches of History of Astronomy (concluded) ; M.Gills. Public Sun…

Diarylethenes in Optically Switchable Organic Light-Emitting Diodes: Direct Investigation of the Reversible Charge Carrier Trapping Process

2021

Advanced optical materials 10, (2021). doi:10.1002/adom.202101116

The Riemannian manifold of all Riemannian metrics

1991

In this paper we study the geometry of (M, G) by using the ideas developed in [Michor, 1980]. With that differentiable structure on M it is possible to use variational principles and so we start in section 2 by computing geodesics as the curves in M minimizing the energy functional. From the geodesic equation, the covariant derivative of the Levi-Civita connection can be obtained, and that provides a direct method for computing the curvature of the manifold. Christoffel symbol and curvature turn out to be pointwise in M and so, although the mappings involved in the definition of the Ricci tensor and the scalar curvature have no trace, in our case we can define the concepts of ”Ricci like cu…

Infinitesimal Hilbertianity of Weighted Riemannian Manifolds

2018

AbstractThe main result of this paper is the following: anyweightedRiemannian manifold$(M,g,\unicode[STIX]{x1D707})$,i.e., a Riemannian manifold$(M,g)$endowed with a generic non-negative Radon measure$\unicode[STIX]{x1D707}$, isinfinitesimally Hilbertian, which means that its associated Sobolev space$W^{1,2}(M,g,\unicode[STIX]{x1D707})$is a Hilbert space.We actually prove a stronger result: the abstract tangent module (à la Gigli) associated with any weighted reversible Finsler manifold$(M,F,\unicode[STIX]{x1D707})$can be isometrically embedded into the space of all measurable sections of the tangent bundle of$M$that are$2$-integrable with respect to$\unicode[STIX]{x1D707}$.By following the…