Search results for "93"

El análisis marxista de las necesidades sociales

2018

The disappearance of the so-called «real socialism» has concealed the validity of the Marxist analysis of social reality. One of the sets of hypotheses that has best maintained its heuristic capacity is the Marxist theory of needs. The Marxist hypotheses have been developed in debate with other conventional conceptions. Currently, feminism and the ecological analysis of needs are renewing the views of Heller and Habermas.

"Ostanko pyörän vai lähdenkö Amerikkaan?" : monimuuttajat Pohjois-Amerikkaan Ilmajoelta 1893-1920

2015

*Ostanko pyörän vai lähdenkö Amerikkaan, on ilmajokelainen sananparsi Aulis J. Alasen vuonna 1953 ilmestyneestä teoksesta Ilmajoki vuoden 1809 jälkeen. Tutkimus selvittää eteläpohjalaisen Ilmajoen paikkakunnan muuttoilmiötä Pohjois- Amerikkaan vuosina 1893 – 1920, keskittyen monimuuttajiin eli henkilöihin jotka ovat lähteneet matkalle useammin kuin kerran viimeistään vuonna 1920. Lähteinä tutkimuksessa on käytetty Siirtolaisuusinstituutin siirtolaisrekisterin passi- ja matkustajaluetteloita sekä Ellis Island ja Ancestry internetpohjaisia tietokantoja. Arkistolähteinä on käytetty myös pääosin Ilmajoen seurakunnan kirkonarkistoja ja täydentävin osin muiden seurakuntien ja maistraattien arkist…

Artificial cartilage bio-matrix formed of hyaluronic acid and Mg2+-polyphosphate.

2016

Here we show that inorganic polyphosphate (polyP), a polyanionic metabolic regulator consisting of multiple phosphate residues linked by energy-rich phosphoanhydride bonds, is present in the synovial fluid. In a biomimetic approach, to enhance cartilage synthesis and regeneration, we prepared amorphous polyP microparticles with Mg2+ as counterions. The particles were characterised by X-ray diffraction (XRD), energy-dispersive X-ray (EDX) and Fourier transformed infrared spectroscopic (FTIR) analyses. Similar particles were obtained after addition of Mg2+ ions to a solution containing hyaluronic acid, as a major component of the synovial fluid, and soluble Na-polyP. The viscous paste-like ma…

Sinivalkoisilta siiviltä kiiltäville kiskoille : matkailukuljetukset ja niiden markkinointi itsenäisessä Suomessa ennen II maailmansotaa

1996

Modelling of rotations by using matrix solutions of nonlinear wave equations

2007

A family of matrix solutions of nonlinear wave equations is extended and its application to modelling is given. It is shown that a similarity transformation, induced by the matrix solution, is equivalent to the rotation. Matrix solutions are used for modelling helical motions and vortex rings, simultaneous rotations and particles collision, mapping contraction and pulsating spheres. Geometrical interpretation of the doubling of rotation angle in each step of sequential mapping contraction is given. First Published Online: 14 Oct 2010

Modeling Political Corruption in Spain

2021

Political corruption is a universal phenomenon. Even though it is a cross-country reality, its level of intensity and the manner of its effect vary worldwide. In Spain, the demonstrated political corruption cases that have been echoed by the media in recent years for their economic, judicial and social significance are merely the tip of the iceberg as regards a problem hidden by many interested parties, plus the shortage of the means to fight against it. This study models and quantifies the population at risk of committing political corruption in Spain by identifying and quantifying the drivers that explain political corruption. Having quantified the problem, the model allows changes to be …

2020

X-chromosomal retinitis pigmentosa (RP) frequently is caused by mutations in the retinitis pigmentosa GTPase regulator (RPGR) gene. We evaluated the potential of PTC124 (Ataluren, TranslamaTM) treatment to promote ribosomal read-through of premature termination codons (PTC) in RPGR. Expression constructs in HEK293T cells showed that the efficacy of read-through reagents is higher for UGA than UAA PTCs. We identified the novel hemizygous nonsense mutation c.1154T > A, p.Leu385* (NM_000328.3) causing a UAA PTC in RPGR and generated patient-derived fibroblasts. Immunocytochemistry of serum-starved control fibroblasts showed the RPGR protein in a dot-like expression pattern along the primary…

Glucose 6-P dehydrogenase delays the onset of frailty by protecting against muscle damage.

2021

Background: Frailty is a major age-associated syndrome leading to disability. Oxidative damage plays a significant role in the promotion of frailty. The cellular antioxidant system relies on reduced nicotinamide adenine dinucleotide phosphate (NADPH) that is highly dependent on glucose 6-P dehydrogenase (G6PD). The G6PD-overexpressing mouse (G6PD-Tg) is protected against metabolic stresses. Our aim was to examine whether this protection delays frailty. Methods: Old wild-type (WT) and G6PD-Tg mice were evaluated longitudinally in terms of frailty. Indirect calorimetry, transcriptomic profile, and different skeletal muscle quality markers and muscle regenerative capacity were also investigate…

Blocking Jak/STAT signalling using tofacitinib inhibits angiogenesis in experimental arthritis

2021

Abstract Objective During rheumatoid arthritis (RA), the angiogenic processes, occurring with pannus-formation, may be a therapeutic target. JAK/STAT-pathway may play a role and the aim of this work was to investigate the inhibiting role of a JAK-inhibitor, tofacitinib, on the angiogenic mechanisms occurring during RA. Methods After ethical approval, JAK-1, JAK-3, STAT-1, STAT-3 and VEGF expression was evaluated on RA-synovial-tissues. In vitro, endothelial cells (ECs), stimulated with 20 ng/ml of VEGF and/or 1 μM of tofacitinib, were assessed for tube formation, migration and proliferation, by Matrigel, Boyden chamber assay and ki67 gene-expression. In vivo, 32 mice received collagen (coll…

Spectral Clustering Reveals Different Profiles of Central Sensitization in Women with Carpal Tunnel Syndrome

2021

Identification of subgroups of patients with chronic pain provides meaningful insights into the characteristics of a specific population, helping to identify individuals at risk of chronification and to determine appropriate therapeutic strategies. This paper proposes the use of spectral clustering (SC) to distinguish subgroups (clusters) of individuals with carpal tunnel syndrome (CTS), making use of the obtained patient profiling to argue about potential management implications. SC is a powerful algorithm that builds a similarity graph among the data points (the patients), and tries to find the subsets of points that are strongly connected among themselves, but weakly connected to others.…