Search results for "A12"
showing 10 items of 60 documents
Two-dimensional Banach spaces with polynomial numerical index zero
2009
We study two-dimensional Banach spaces with polynomial numerical indices equal to zero.
Evaluation of serum CA 125 levels in patients with pelvic pain related to endometriosis.
2007
The aim of the study was to investigate the clinical value of the serum CA 125 level for diagnosing and determining the severity of endometriosis and pelvic pain associated with endometriosis. Eighty-six women who underwent operative laparoscopy were enrolled. Sixty-nine women with endometriosis and 17 without endometriosis participated in this study. In all of the patients, endometriosis was diagnosed and classified into stages according to the Revised American Fertility Society (R-AFS) classification. The mean serum CA 125 levels were determined in each patient. We also investigated the relationship between serum CA 125 concentration and the intensity of dysmenorrhea and dyspareunia in t…
Space-filling vs. Luzin's condition (N)
2013
Let us assume that we are given two metric spaces, where the Hausdorff dimension of the first space is strictly smaller than the one of the second space. Suppose further that the first space has sigma-finite measure with respect to the Hausdorff measure of the corresponding dimension. We show for quite general metric spaces that for any measurable surjection from the first onto the second space, there is a set of measure zero that is mapped to a set of positive measure (both measures are the Hausdorff measures corresponding to the Hausdorff dimension of the first space). We also study more general situations where the measures on the two metric spaces are not necessarily the same and not ne…
$\Omega$-symmetric measures and related singular integrals
2019
Let $\mathbb{S} \subset \mathbb{C}$ be the circle in the plane, and let $\Omega: \mathbb{S} \to \mathbb{S}$ be an odd bi-Lipschitz map with constant $1+\delta_\Omega$, where $\delta_\Omega>0$ is small. Assume also that $\Omega$ is twice continuously differentiable. Motivated by a question raised by Mattila and Preiss in [MP95], we prove the following: if a Radon measure $\mu$ has positive lower density and finte upper density almost everywhere, and the limit $$ \lim_{\epsilon \downarrow 0} \int_{\mathbb{C} \setminus B(x,\epsilon)} \frac{\Omega\left((x-y)/|x-y|\right)}{|x-y|} \, d\mu(y) $$ exists $\mu$-almost everywhere, then $\mu$ is $1$-rectifiable. To achieve this, we prove first that if …
Integrability of orthogonal projections, and applications to Furstenberg sets
2022
Let $\mathcal{G}(d,n)$ be the Grassmannian manifold of $n$-dimensional subspaces of $\mathbb{R}^{d}$, and let $\pi_{V} \colon \mathbb{R}^{d} \to V$ be the orthogonal projection. We prove that if $\mu$ is a compactly supported Radon measure on $\mathbb{R}^{d}$ satisfying the $s$-dimensional Frostman condition $\mu(B(x,r)) \leq Cr^{s}$ for all $x \in \mathbb{R}^{d}$ and $r > 0$, then $$\int_{\mathcal{G}(d,n)} \|\pi_{V}\mu\|_{L^{p}(V)}^{p} \, d\gamma_{d,n}(V) \tfrac{1}{2}$ and $t \geq 1 + \epsilon$ for a small absolute constant $\epsilon > 0$. We also prove a higher dimensional analogue of this estimate for codimension-1 Furstenberg sets in $\mathbb{R}^{d}$. As another corollary of our method,…
Revised nomenclature and classification of inherited ichthyoses: Results of the First Ichthyosis Consensus Conference in Soreze 2009
2010
Background: Inherited ichthyoses belong to a large, clinically and etiologically heterogeneous group of mendelian disorders of cornification; typically involving the entire integument. Over the recent years, much progress has been made defining their molecular causes. However, there is no internationally accepted classification and terminology. Objective: We sought to establish a consensus for the nomenclature and classification of inherited ichthyoses. Methods: The classification project started at the First World Conference on Ichthyosis in 2007. A large international network of expert clinicians, skin pathologists, and geneticists entertained an interactive dialogue over 2 years, eventua…
Normal forms of hyperbolic logarithmic transseries
2021
We find the normal forms of hyperbolic logarithmic transseries with respect to parabolic logarithmic normalizing changes of variables. We provide a necessary and sufficient condition on such transseries for the normal form to be linear. The normalizing transformations are obtained via fixed point theorems, and are given algorithmically, as limits of Picard sequences in appropriate topologies.
Dysfunction of Oskyddad causes Harlequin-type ichthyosis-like defects in Drosophila melanogaster.
2020
Prevention of desiccation is a constant challenge for terrestrial organisms. Land insects have an extracellular coat, the cuticle, that plays a major role in protection against exaggerated water loss. Here, we report that the ABC transporter Oskyddad (Osy)—a human ABCA12 paralog—contributes to the waterproof barrier function of the cuticle in the fruit fly Drosophila melanogaster. We show that the reduction or elimination of Osy function provokes rapid desiccation. Osy is also involved in defining the inward barrier against xenobiotics penetration. Consistently, the amounts of cuticular hydrocarbons that are involved in cuticle impermeability decrease markedly when Osy activity is reduced. …
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations
2013
Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we identified and replicated 28 genome-wide significant loci in association with serum urate concentrations (18 new regions in or near TRIM46, INHBB, SFMBT1, TMEM171, VEGFA, BAZ1B, PRKAG2, STC1, HNF4G, A1CF, ATXN2, UBE2Q2, IGF1R, NFAT5, MAF, HLF, ACVR1B-ACVRL1 and B3GNT4). Associations for many of the loci were of similar magnitude in individuals of non-European ancestry. We further characterized these loci for associations with gout, transcript expression and the fractional…
ABC A-subfamily transporters: Structure, function and disease
2006
AbstractABC transporters constitute a family of evolutionarily highly conserved multispan proteins that mediate the translocation of defined substrates across membrane barriers. Evidence has accumulated during the past years to suggest that a subgroup of 12 structurally related “full-size” transporters, referred to as ABC A-subfamily transporters, mediates the transport of a variety of physiologic lipid compounds. The emerging importance of ABC A-transporters in human disease is reflected by the fact that as yet four members of this protein family (ABCA1, ABCA3, ABCR/ABCA4, ABCA12) have been causatively linked to completely unrelated groups of monogenetic disorders including familial high-d…