Search results for "A2"
showing 10 items of 1101 documents
Overexpression of the truncated form of high mobility group a proteins (HMGA2) in human myometrial cells induces leiomyoma-like tissue formation
2014
The pathogenesis of uterine leiomyomas, the most common benign tumor in women, is still unknown. This lack of basic knowledge limits the development of novel non-invasive therapies. Our group has previously demonstrated that leiomyoma side population (SP) cells are present in tumor lesions and act like putative tumor-initiating stemcells in human leiomyoma. Moreover, accumulated evidence demonstrates that these benign tumors of mesenchymal origin are characterized by rearrangements of the High Mobility Group A proteins (HMGA). In this work, we tested the hypothesis that leiomyoma development may be due to overexpression of HMGA2 (encoding high mobility group AT-hook2) in myometrial stem cel…
Calpains promote α2β1 integrin turnover in nonrecycling integrin pathway
2012
A novel virus- and integrin clustering–specific pathway diverts integrin from its normal endo/exocytic traffic to a nonrecycling degradative endosomal route. Clustering of α2β1 integrin causes redistribution of the integrin to perinuclear endosomes, leading to enhanced integrin turnover promoted by calpains.
The endocytic trafficking pathway of oncogenic papillomaviruses
2019
Over the last two decades many host cell proteins have been described to be involved in the process of infectious entry of oncogenic human papillomaviruses (HPV). After initial binding and priming of the capsid, a sequence of events on the cell surface precedes the formation of the HPV entry platform. It has been shown that the virus-associated entry complex consists of membrane organizers, tetraspanins CD151 and CD63, and their associated partner proteins such as integrins, growth factor receptors, and the annexin A2 heterotetramer. Further recruitment of cytoplasmic factors such as the obscurin-like protein 1 and actin results in a non-canonical clathrin-independent endocytosis of the vir…
As-built graphic documentation of the Monumento a la Tolerancia. Validation of low-cost survey techniques
2020
[EN] The Monumento a la Tolerancia is an emblematic sculpture realized by Eduardo Chillida, a perfect example for the documentation of sculptures with uniform textures, non-reflective colours and with poorly elaborated shapes through the implementation of various photogrammetric tools, as well as using different applications for processing phase. The basic data are photos taken quickly and without an accurate previous study, which is why the implementation of any target was not foreseen. In order to prove the results different kind of analysis were conducted. The first type was carried out analysing the results obtained from different software, with the use of the same instrument. The secon…
Energy Efficient Resource Allocation for OFDMA Two-Way Relay Networks with Channel Estimation Error
2015
In this work, we consider the practical issues of resource allocation problem in OFDMA two-way relay networks: the inaccuracy of channel-state information (CSI) available to the transmitters. Instead, only the estimated channel status is known by the transmitters. In this context, a joint optimization of subcarrier pairing and allocation, relay selection and transmit power allocation is formulated in the OFDMA two-way amplify-and-forward relay networks. Moreover, to ensure the Quality of Service (QoS) requirement, the energy consumption must be minimized without compromising the QoS. Therefore, by applying convex optimization techniques, energy efficient algorithms are developed with the ob…
Multicriteria evaluation of carbon-neutral heat-only production technologies for district heating
2018
Climate change mitigation requires reducing dependence on fossil fuels and transition to low carbon energy production technologies. Nearly half of the global final energy consumption is thermal energy produced from technologies with high carbon dioxide emission. As such, it is imperative to employ carbon-neutral heat production to achieve a sustainable energy system. This paper presents a real-life case of applying multicriteria decision analysis for evaluating carbon-neutral heat-only production technologies in a major district heating system in Finland. A group of 10 experts from the energy company contributed in defining the alternative technologies and multiple economic, technological, …
Photovoltaic plant array reconfiguration: Design of a new device
2014
An efficient strategy to improve unequally irradiated PV plants performances is based on the reconfiguration of the connections between the modules. In this paper, an algorithm, for this purpose conceived, is presented. Moreover, the design, realization and finally also the set up of a new reconfiguration system device is fully shown and discussed. The algorithm conceived simulates several possible series-parallel connections under varying irradiation conditions, and determines the optimal modules connection in order to get the maximum output power. In this way, the reconfiguration system may set up the reconfiguration strategy. The reconfiguration system prototype set up, basically consist…
Multicriteria evaluation of sustainable energy solutions for Colosseum
2017
Abstract Colosseum is a large office building in the capital region of Finland. The building owner operates on the highly competitive office rental market. With increasing emphasis on environmental responsibility, energy efficiency and sustainable energy solutions can provide competitive edge on the rental market. This study evaluates in terms of multiple criteria different alternatives to enhance the energy solutions of the building. The alternatives included different configurations of solar power, ground source heat, and roof constructions, along with district heating. Decision criteria included internal rate of return, energy efficiency, CO2 emissions, and attractiveness. Attractiveness…
Clean and Sustainable Biodiesel Production
2015
To date, the majority of world's primary energy is derived from fossil fuels. However, the fossil fuel recourses are in an inevitable decline as energy demand continues to grow exponentially with population growth, urbanization, and improved standards of living. Crude oil prices have recently risen several times and their current annual volatility exceeds 30%. The potential scarcity of fossil fuels has prompted a global search for alternative energy resources. Biodiesel fulfills the major requirements for production of alternative fuels such as feedstock availability, technical feasibility, and economic competitiveness. Together with other renewable biofuels, the use of biodiesel as a subst…
A Multi-Position Calibration Method for Consumer-Grade Accelerometers, Gyroscopes, and Magnetometers to Field Conditions
2017
This paper presents a calibration method for consumer-grade accelerometers, gyroscopes, and magnetometers. Considering the calibration of consumer-grade sensors, it is essential that no specialized equipment is required to create reference signals. In addition, the less is required from the reference signals, the more suitable the method is on the field. In the proposed method, the novelty in the calibration of the gyroscopes lies in the exploitation of only the known net rotations between the positions in a multi-position calibration. For accelerometers and magnetometers, the innovation is that the direction of reference signals, the gravity and the magnetic field of the Earth, are estimat…