Search results for "A2"
showing 10 items of 1101 documents
Catalytic effect of Ca and K on CO2 gasification of spruce wood char
2015
Abstract Gasification is one route to produce chemicals and liquid fuels from biomass. The gasification of the char is catalyzed by alkali and alkaline earth metals in the biomass. In this work the catalytic effect of calcium (Ca) and potassium (K) on CO2 gasification of spruce wood was studied using a thermo gravimetric analyzer (TGA). The ash-forming elements were first removed from the wood using an acid leaching method. Then, various concentrations of K and Ca were absorbed to the wood by ion-exchange to carboxylic and phenolic groups, impregnation of K2CO3 or physically mixing of CaC2O4. The prepared spruce samples were placed in a mesh holder and gasified in the TGA at 850 °C in 100% …
Uniqueness of positive radial solutions to singular critical growth quasilinear elliptic equations
2015
In this paper, we prove that there exists at most one positive radial weak solution to the following quasilinear elliptic equation with singular critical growth \[ \begin{cases} -\Delta_{p}u-{\displaystyle \frac{\mu}{|x|^{p}}|u|^{p-2}u}{\displaystyle =\frac{|u|^{\frac{(N-s)p}{N-p}-2}u}{|x|^{s}}}+\lambda|u|^{p-2}u & \text{in }B,\\ u=0 & \text{on }\partial B, \end{cases} \] where $B$ is an open finite ball in $\mathbb{R}^{N}$ centered at the origin, $1<p<N$, $-\infty<\mu<((N-p)/p)^{p}$, $0\le s<p$ and $\lambda\in\mathbb{R}$. A related limiting problem is also considered.
On the fractional probabilistic Taylor's and mean value theorems
2016
In order to develop certain fractional probabilistic analogues of Taylor's theorem and mean value theorem, we introduce the nth-order fractional equilibrium distribution in terms of the Weyl fractional integral and investigate its main properties. Specifically, we show a characterization result by which the nth-order fractional equilibrium distribution is identical to the starting distribution if and only if it is exponential. The nth-order fractional equilibrium density is then used to prove a fractional probabilistic Taylor's theorem based on derivatives of Riemann-Liouville type. A fractional analogue of the probabilistic mean value theorem is thus developed for pairs of nonnegative rand…
Linkage studies of bipolar disorder in the region of the Darier's disease gene on chromosome 12q23-24.1.
1995
We have recently described a family in which there is cosegregation of major affective disorder with Darier's disease and have mapped this autosomal dominant skin disorder to 12q23-q24.1. This has provided an interesting candidate region for genetic studies of bipolar disorder. We have studied the segregation of seven markers spanning the Darier's disease locus in 45 bipolar disorder pedigrees and found modest evidence in support of linkage under heterogeneity for 5 of these markers. Nonparametric analyses were suggestive of linkage with a marker at the gene encoding a secretory form of phospholipase A2. Our sample has relatively low power to detect linkage under heterogeneity and independe…
Founder mutations in BRCA1 and BRCA2 genes
2007
BRCA1 and BRCA2 germline mutations contribute to a significant number of familial and hereditary breast and/or ovarian cancers. The proportion of high-risk families with breast and/or ovarian cancer cases due to mutations in these tumor suppressor genes varies widely among populations. In some population, a wide spectrum of different mutations in both genes are present, whereas in other groups specific mutations in BRCA1 and BRCA2 have been reported with high frequency. Most of these mutations are prevalent in restricted populations as consequence of a founder effect. The comparison of haplotypes between families with the same mutation can distinguish whether high-frequency alleles derive f…
A Potent Tumor-Reactive p53-Specific Single-Chain TCR without On- or Off-Target Autoimmunity In Vivo
2018
Genetic engineering of T cells with a T cell receptor (TCR) targeting tumor antigen is a promising strategy for cancer immunotherapy. Inefficient expression of the introduced TCR due to TCR mispairing may limit the efficacy and adversely affect the safety of TCR gene therapy. Here, we evaluated the safety and therapeutic efficiency of an optimized single-chain TCR (scTCR) specific for an HLA-A2.1-restricted (non-mutated) p53(264–272) peptide in adoptive T cell transfer (ACT) models using our unique transgenic mice expressing human p53 and HLA-A2.1 that closely mimic the human setting. Specifically, we showed that adoptive transfer of optimized scTCR-redirected T cells does not induce on-tar…
Direct evidence for positive selection of skin, hair, and eye pigmentation in Europeans during the last 5,000 y
2014
Significance Eye, hair, and skin pigmentation are highly variable in humans, particularly in western Eurasian populations. This diversity may be explained by population history, the relaxation of selection pressures, or positive selection. To investigate whether positive natural selection is responsible for depigmentation within Europe, we estimated the strength of selection acting on three genes known to have significant effects on human pigmentation. In a direct approach, these estimates were made using ancient DNA from prehistoric Europeans and computer simulations. This allowed us to determine selection coefficients for a precisely bounded period in the deep past. Our results indicate t…
Specific and promiscuous functions of multiple DnaJ proteins in Synechocystis sp. PCC 6803
2011
Cyanobacterial genomes typically encode multiple Hsp70 (DnaK) and Hsp40 (DnaJ) chaperones, and in the genome of the cyanobacteriumSynechocystisPCC 6803, three DnaK proteins are encoded together with seven DnaJ proteins. While only two of the DnaJ proteins can complement the growth defect of anEscherichia coliΔdnaJstrain, only disruption of thednaJgenesll0897resulted in a growth defect at elevated temperatures. Based on the domain structure and the phenotype observed following disruption of the encoding gene, Sll0897 can be classified as a canonical heat-shock protein inSynechocystis. Furthermore, mostdnaJgenes could be deleted individually, whereas disruption of the gene encoding the DnaJ S…
Hypoxia and Human Genome Stability: Downregulation of BRCA2 Expression in Breast Cancer Cell Lines
2013
Previously, it has been reported that hypoxia causes increased mutagenesis and alteration in DNA repair mechanisms. In 2005, an interesting study showed that hypoxia-induced decreases in BRCA1 expression and the consequent suppression of homologous recombination may lead to genetic instability. However, nothing is yet known about the involvement of BRCA2 in hypoxic conditions in breast cancer. Initially, a cell proliferation assay allowed us to hypothesize that hypoxia could negatively regulate the breast cancer cell growth in short term in vitro studies. Subsequently, we analyzed gene expression in breast cancer cell lines exposed to hypoxic condition by microarray analysis. Interestingly,…
GIS-data related route optimization, hierarchical clustering, location optimization, and kernel density methods are useful for promoting distributed …
2019
Currently, geographic information system (GIS) models are popular for studying location-allocation-related questions concerning bioenergy plants. The aim of this study was to develop a model to investigate optimal locations for two different types of bioenergy plants, for farm and centralized biogas plants, and for wood terminals in rural areas based on minimizing transportation distances. The optimal locations of biogas plants were determined using location optimization tools in R software, and the optimal locations of wood terminals were determined using kernel density tools in ArcGIS. The present case study showed that the utilized GIS tools are useful for bioenergy-related decision-maki…