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RESEARCH PRODUCT
Linkage studies of bipolar disorder in the region of the Darier's disease gene on chromosome 12q23-24.1.
M. LanczikWolfgang MaierQueta RobertsE. ParfittPeter ProppingMarkus M. NöthenPak C. ShamElisabeth DawsonJo DanielsMichael John OwenMichael GillPeter McguffinNicholas John CraddockNicholas John CraddockJohn PowellJean WeissenbachUlrike ReunerLionel C. C. Limsubject
Genetic MarkersMaleCandidate geneBipolar DisorderCosegregationGenotypeGenetic LinkageLocus (genetics)BiologyPhospholipases AGene mappingDarier DiseaseGenetic linkageDarier's diseasemedicineHumansBipolar disorderGenetics (clinical)AllelesGenes DominantGeneticsChromosomes Human Pair 12Chromosome Mappingmedicine.diseasePedigreePhospholipases A2FemaleLod ScoreDarier Diseasedescription
We have recently described a family in which there is cosegregation of major affective disorder with Darier's disease and have mapped this autosomal dominant skin disorder to 12q23-q24.1. This has provided an interesting candidate region for genetic studies of bipolar disorder. We have studied the segregation of seven markers spanning the Darier's disease locus in 45 bipolar disorder pedigrees and found modest evidence in support of linkage under heterogeneity for 5 of these markers. Nonparametric analyses were suggestive of linkage with a marker at the gene encoding a secretory form of phospholipase A2. Our sample has relatively low power to detect linkage under heterogeneity and independent researchers should examine markers from this region in further samples of bipolar pedigrees.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1995-04-24 | American journal of medical genetics |