Search results for "AA"

Toxicological and bioactivity evaluation of blackcurrant press cake, sea buckthorn leaves and bark from Scots pine and Norway spruce extracts under a…

2021

Aqueous extracts from blackcurrant press cake (BC), Norway spruce bark (NS), Scots pine bark (SP), and sea buckthorn leaves (SB) were obtained using maceration and pressurized hot water and tested for their bioactivities. Maceration provided the extraction of higher dry matter contents, including total phenolics (TPC), anthocyanins, and condensed tannins, which also impacted higher antioxidant activity. NS and SB extracts presented the highest mean values of TPC and antioxidant activity. Individually, NS extract presented high contents of proanthocyanidins, resveratrol, and some phenolic acids. In contrast, SB contained a high concentration of ellagitannins, ellagic acid, and quercetin, exp…

The HCV Sicily Network: A web-based model for the management of HCV chronic liver diseases

2016

Epidemiological studies report that in Sicily reside about 30,000 citizens with a diagnosis of chronic hepatitis due to HCV. The availability of direct antiviral action (DAA) is a real therapeutic breakthrough, but the high cost of the therapeutic regimes limits their use and forced the National Health System to establish clinical priority for the treatment.The HCV Sicily Network is a web-based model of best medical practice, which was designed to improve the management and the treatment of HCV chronic hepatitis and cirrhosis. The network includes 41 centers and 84 gastroenterologists or infectivologists connected by a web platform that recorder the diagnosis and the clinic priority for the…

Efficacy and safety of bempedoic acid for the treatment of hypercholesterolemia: A systematic review and meta-analysis

2020

Background Bempedoic acid is a first-in-class lipid-lowering drug recommended by guidelines for the treatment of hypercholesterolemia. Our objective was to estimate its average effect on plasma lipids in humans and its safety profile. Methods and findings We carried out a systematic review and meta-analysis of phase II and III randomized controlled trials on bempedoic acid (PROSPERO: CRD42019129687). PubMed (Medline), Scopus, Google Scholar, and Web of Science databases were searched, with no language restriction, from inception to 5 August 2019. We included 10 RCTs (n = 3,788) comprising 26 arms (active arm [n = 2,460]; control arm [n = 1,328]). Effect sizes for changes in lipids and high-…

Les métaphores dans L'Enchanteur pourrissant de Guillaume Apollinaire

2001

Mätänevän velhon taidejulistus : intertekstuaalisen ja -figuraalisen aineiston asema Apollinairen L'enchanteur pourrissant teoksen tematiikassa ja sy…

2008

Ranskalainen modernisti Guillaume Apollinaire (1880-1918) marssittaa esikoisteoksessaan L’Enchanteur pourrissant (1909) kuolemattoman velhon haudalle vanhentuneen Troijan Helenan. Rapistuneen kaunottaren ohella mädäntyvän tietäjän lihaa saapuvat haistelemaan mm. viehkeytensä menettäneet juoruileviksi naisiksi muuttuneet haltijattaret, höperöityneet antiikin filosofit ja Raamatun kuolemattomat pyhimykset, jotka ovat unohtaneet uskonsa merkityksen. Apollinairen luomassa groteskissa maailmassa vanha myyttinen perintö kuolee ja mätänee samalla kun maailma vajoaa dekadenttiseen rappioonsa. Riikka Mahlamäki-Kaistisen tutkima Apollinaire on yksi tärkeimmistä 1900-luvun alun ranskalaisista kirjaili…

Guillaume Apollinaire, hymyilevä varas : intertekstuaalisuuden muodot L'Enchanteur pourrissant -teoksessa

2001

Identification of multiplicatively acting modulatory mutational signatures in cancer

2022

Abstract Background A deep understanding of carcinogenesis at the DNA level underpins many advances in cancer prevention and treatment. Mutational signatures provide a breakthrough conceptualisation, as well as an analysis framework, that can be used to build such understanding. They capture somatic mutation patterns and at best identify their causes. Most studies in this context have focused on an inherently additive analysis, e.g. by non-negative matrix factorization, where the mutations within a cancer sample are explained by a linear combination of independent mutational signatures. However, other recent studies show that the mutational signatures exhibit non-additive interactions. Resu…

Thin obstacle problem : Estimates of the distance to the exact solution

2018

We consider elliptic variational inequalities generated by obstacle type problems with thin obstacles. For this class of problems, we deduce estimates of the distance (measured in terms of the natural energy norm) between the exact solution and any function that satisfies the boundary condition and is admissible with respect to the obstacle condition (i.e., they are valid for any approximation regardless of the method by which it was found). Computation of the estimates does not require knowledge of the exact solution and uses only the problem data and an approximation. The estimates provide guaranteed upper bounds of the error (error majorants) and vanish if and only if the approximation c…

The Calderón problem for the fractional Schrödinger equation

2020

We show global uniqueness in an inverse problem for the fractional Schr\"odinger equation: an unknown potential in a bounded domain is uniquely determined by exterior measurements of solutions. We also show global uniqueness in the partial data problem where the measurements are taken in arbitrary open, possibly disjoint, subsets of the exterior. The results apply in any dimension $\geq 2$ and are based on a strong approximation property of the fractional equation that extends earlier work. This special feature of the nonlocal equation renders the analysis of related inverse problems radically different from the traditional Calder\'on problem.

Effects of high intensity resistance aquatic training on body composition and walking speed in women with mild knee osteoarthritis : a 4-month RCT wi…

2017

Objective: To investigate the effects of 4-months intensive aquatic resistance training on body composition and walking speed in post-menopausal women with mild knee osteoarthritis (OA), immediately after intervention and after 12-months follow-up. Additionally, influence of leisure time physical activity (LTPA) will be investigated. Design: This randomised clinical trial assigned eighty-seven volunteer postmenopausal women into two study arms. The intervention group (n = 43) participated in 48 supervised intensive aquatic resistance training sessions over 4-months while the control group (n = 44) maintained normal physical activity. Eighty four participants continued into the 12-months' fo…