Search results for "ABC"
showing 10 items of 170 documents
Iron in Translation: From the Beginning to the End
2021
Iron is an essential element for all eukaryotes, since it acts as a cofactor for many enzymes involved in basic cellular functions, including translation. While the mammalian iron-regulatory protein/iron-responsive element (IRP/IRE) system arose as one of the first examples of translational regulation in higher eukaryotes, little is known about the contribution of iron itself to the different stages of eukaryotic translation. In the yeast Saccharomyces cerevisiae, iron deficiency provokes a global impairment of translation at the initiation step, which is mediated by the Gcn2-eIF2α pathway, while the post-transcriptional regulator Cth2 specifically represses the translation of a subgroup of…
Lasten ryhmäperustainen, verbaalis-kognitiivinen motoriikkaharjoittelu : interventiotutkimus
2010
Tutkimuksen tarkoituksena oli selvittää miten opettajat pystyvät seulomaan yleisopetuksen alaluokilta lapsia, joilla on lieviä motorisen oppimisen vaikeuksia. Lisäksi tutkittiin 10 viikkoa kestäneen motoriikkaa kuntouttavan kognitiivisen harjoitusohjelman vaikutuksia. Kolmantena teemana oli motivaation ja mielialan kehittyminen kerhokerran aikana. Harjoitusohjelma toteutettiin koulun iltapäiväkerhona eräässä keskisuomalaisessa koulussa lukuvuonna 2009–2010. Osallistujat seulottiin neljältä alaluokalta (1–2lk) opettajien täyttämällä koordinaatiokyselyllä (Developmental Coordination Disorder -Questionnare, DCDQ ). Harjoittelun vaikutuksia selvitettiin alku-, loppu- ja pysyvyysmittauksilla, jo…
2020
The efficiency of chemotherapy drugs can be affected by ATP-binding cassette (ABC) transporter expression or by their mutation status. Multidrug resistance is linked with ABC transporter overexpression. In the present study, we performed rare mutation analyses for 12 ABC transporters related to drug resistance (ABCA2, -A3, -B1, -B2, -B5, -C1, -C2, -C3, -C4, -C5, -C6, -G2) in a dataset of 18 cancer patients. We focused on rare mutations resembling tumor heterogeneity of ABC transporters in small tumor subpopulations. Novel rare mutations were found in ABCC1, but not in the other ABC transporters investigated. Diverse ABCC1 mutations were found, including nonsense mutations causing premature …
The U(p+1) Formalism Applied to The Vibrational Hamiltonians of Nonlinear ABC Molecules
2000
Prognostic factors for progression-free and overall survival in advanced biliary tract cancer
2015
BACKGROUND: Biliary tract cancer is an uncommon cancer with a poor outcome. We assembled data from the National Cancer Research Institute (UK) ABC-02 study and 10 international studies to determine prognostic outcome characteristics for patients with advanced disease.METHODS: Multivariable analyses of the final dataset from the ABC-02 study were carried out. All variables were simultaneously included in a Cox proportional hazards model, and backward elimination was used to produce the final model (using a significance level of 10%), in which the selected variables were associated independently with outcome. This score was validated externally by receiver operating curve (ROC) analysis using…
Modular Phosphole-Methano-Bridged-Phosphine(Borane) Ligands. Application to Rhodium-Catalyzed Reactions
2012
The synthesis of the phospholyl(phosphinoborane)methane air- and moisture-stable hybrid ligands 4a–f, starting from 1-phenylphospholes 1a–d, was performed via P–C bond coupling on the methano bridge. Two strategies were investigated, according to the phospholyl moiety used as a nucleophilic or an electrophilic reagent. In the first pathway, the phospholyl anions react with the easily available (chloromethyl)diphenylphosphine–borane 3 to afford ligands 4a–d in 29–67% isolated yields. In the second pathway, the phospholyl(dicyclohexylphosphinoborane)methane ligands 4e,f were synthesized in 18–23% yields, through a nucleophilic substitution on the cyanophosphole. Removal of the BH3 moiety on 4…
Efficient synthesis of racemic and chiral alkenyl sulfoxides by palladium-catalyzed Suzuki coupling
2010
Alkenyl sulfoxide derivatives are obtained in high yields through a palladium-catalyzed Suzuki/Miyaura cross-coupling reaction of racemic and chiral 1-halo sulfoxides with aryl and alkenyl boronic acids. Chiral substrates react with no loss of optical purity and high optical yields. The reaction takes place with different palladium catalysts, such as Pd(PPh 3 ) 4 or Pd(OAc) 2 /DABCO. Although nitrogen ligands like DABCO lead to an active palladium catalyst, they are less effective than the phosphine ones.
MCC1019, a selective inhibitor of the Polo-box domain of Polo-like kinase 1 as novel, potent anticancer candidate
2019
Polo-like kinase (PLK1) has been identified as a potential target for cancer treatment. Although a number of small molecules have been investigated as PLK1 inhibitors, many of which showed limited selectivity. PLK1 harbors a regulatory domain, the Polo box domain (PBD), which has a key regulatory function for kinase activity and substrate recognition. We report on 3-bromomethyl-benzofuran-2-carboxylic acid ethyl ester (designated: MCC1019) as selective PLK1 inhibitor targeting PLK1 PBD. Cytotoxicity and fluorescence polarization-based screening were applied to a library of 1162 drug-like compounds to identify potential inhibitors of PLK1 PBD. The activity of compound MC1019 against the PLK1…
Autististen lasten kuntoutus TEACCH-orientoituneessa pienryhmässä päiväkodissa : neljä tapaustutkimusta
1998
Quels outils et méthodes pour piloter les coûts et les performances des partenariats ?
2004
International audience; Comment les entreprises qui nouent des partenariats organisent-elles leur pilotage et leur contrôle? Nous proposerons d'abord une description des mécanismes de pilotage et de contrôle des différents partenariats. Puis nous présenterons les méthodes de gestion des coûts adaptées à ceux-ci. Une étude de cas complétera notre réflexion.