Search results for "ABR"
showing 10 items of 1669 documents
Terra Incognita Australis de Foigny. El descubrimiento de una nueva tierra, el desarrollo de la novela
2019
Desde finales del siglo xv al xvii, viajeros de diferentes países europeos intentaron llegar a un continente austral desconocido, supuestamente situado en algún lugar entre las tierras africanas y americanas. Una de las narraciones más populares sobre este continente en Inglaterra a finales del siglo xvii fue A New Discovery of Terra Incognita Australis, or the Southern World, de Gabriel de Foigny, publicada en 1693 por John Dunton y, de hecho, una traducción de la versión francesa de 1692. Aunque esta obra de la novela inglesa temprana es citada por varios estudiosos, se ha realizado poco trabajo crítico sobre la versión inglesa. En consecuencia, el objetivo de este artículo es sacar a la …
Differential influence of vemurafenib and dabrafenib on patient lymphocytes despite similar clinical efficacy in melanoma
2014
Background: Since the majority of melanomas eventually become resistant and progress, combining selective BRAF inhibitors (BRAFi) with immunotherapies has been proposed to achieve more durable treatment responses. Here, we explored the impact of selective BRAFi on the hosts’ immune system. Patients and methods: Clinical data, whole blood counts (WBC) and serum lactate dehydrogenase (LDH) of 277 vemurafenib- and 65 dabrafenib-treated melanoma patients were evaluated. The frequency and phenotype of lymphocyte subpopulations were determined by flow cytometry while T cell cytokine secretion was measured by multiplex assays. Results: Progression-free survival (PFS) as well as overall survival (O…
Un voyage en Finlande, c'est un voyage au pays du père Noël, là où les rêves deviennent réalité : L'image de la Finlande sur les sites Internet franç…
2012
Tämän tutkielman korpuksena on käytetty seitsemän ranskalaisen matkanjärjestäjän nettisivua. Tutkimuksessa tutkitaan näiden sivujen luomaa Suomi-kuvaa ja nähdään, miten eri tekijät, kuten brändäys, stereotypiat, tuotevalinnat ja kohderyhmät, voivat vaikuttaa maakuvan muodostamiseen. Tutkimuksessa myös verrataan ranskalaisten matkanjärjestäjien ja MEK:n, Matkailun edistämiskeskuksen, Suomi-kuvaa.
‘Vestiunt silve tenera ramorum: La versione cantabrigiense e la versione veronese’
1998
Anàlisi de les unitats fraseològiques amb funció connectiva en un fragment de conversa col·loquial
2010
L’article se centra en l’anàlisi de les estructures prefabricades, és a dir, de caràcter fraseològic, que indiquen connexió, en un fragment de conversa col·loquial. S’hi analitza el distint grau de gramaticalització que presenten i els valors connectius que indiquen en cada context. Es para especial atenció a la construcció és que, que presenta un grau relativament baix de gramaticalització i que només contextualment pot indicar relacions connectives.
Nanocomposites: Síntesis, caracterización y aplicaciones
2018
En las últimas décadas la nanotecnología ha avanzado a una velocidad vertiginosa, haciendo posible la manipulación de las propiedades de los materiales al controlar la materia a niveles nanométricos y logrando metas impensables hasta hace unas pocas décadas. Sin embargo, al tratarse de una ciencia relativamente reciente, queda mucho potencial por explotar. Es indispensable un avance científico multidisciplinar para lograr superar con éxito las actuales limitaciones tecnológicas para que continúe el progreso. Para ello serán indispensables tanto la obtención de nuevos materiales con propiedades manipulables, como el desarrollo de métodos de fabricación que permitan integrar estos materiales …
Data from: Cleaner fish escape salmon farms and hybridize with local wrasse populations
2018
The genetic impact of farmed fish escaping aquaculture is a highly debated issue. However, non-target species, such as cleaner fish used to remove sea lice from farmed fish, are rarely considered. Here we report that wild corkwing wrasse (Symphodus melops), which are transported long distances to be used as cleaner fish in salmon farms, escape and hybridize with local populations. Recently, increasing numbers of corkwing wrasse have been reported in Flatanger in Norway, north of its described distribution range, an area heavily relying on import of cleaner fish from Skagerrak. Using genetic markers identified with 2bRAD sequencing, we show that, although the Flatanger population largely is …
The Mainz Severity Score Index: a new instrument for quantifying the Anderson-Fabry disease phenotype, and the response of patients to enzyme replace…
2004
Anderson-Fabry disease (AFD) is an X-linked disorder caused by deficient activity of the lysosomal enzyme alpha-galactosidase A. The availability of enzyme replacement therapy (ERT) for this debilitating condition has led to the need for a convenient and sensitive instrument to monitor clinical effects in an individual patient. This study aimed to develop a scoring system--the Mainz Severity Score Index (MSSI)--to measure the severity of AFD and to monitor the clinical course of the disease in response to ERT. Thirty-nine patients (24 males and 15 females) with AFD were assessed using the MSSI immediately before and 1 year after commencing agalsidase alfa ERT. Control data were obtained fro…
Peritoneal cavity phagocytes from the teleost sea bass express a glucocorticoid receptor (cloned and sequenced) involved in genomic modulation of the…
2005
Abstract To gain further insight into the role of cortisol in Wsh innate immune responses, we cloned and sequenced a 2592 bp cDNA from sea bass (Dicentrarchus labrax) peritoneal leukocytes (PCLs) encoding a glucocorticoid receptor (DlGR1). The deduced aminoacid sequence displayed that DlGR1 belong to a multigenic family of steroid hormone receptors, and exhibited high homology (80%) to the Burton’s mouth breeder (Haplochromis burtoni) HbGR1. The DlGR1 functional domains presented homologies with those of several vertebrate species. In situ hybridization assay revealed that DlGR1 was expressed in macrophages and neutrophils from the peritoneal cavity. Since in a previous paper, sea bass PCL …
A new technique for the treatment of nasal telangiectasia using atmospheric plasma (voltaic arc dermabrasion): Postoperative pain assessment by therm…
2020
Background Nasal telangiectasias are superficial, small vessels in the ala nasi and nasolabial crease with a varying origin. They represent an unaesthetic condition, frustrating patients who frequently request their removal. Microsclerotherapy, electrosurgery, different types of laser therapy, needle-assisted electrocoagulation, and TRASER therapy have been described for treating this condition. Aims The aim of this study is to describe a novel technique that removes nasal telengectiasias using voltaic arc dermabrasion (VAD). Patients/methods Voltaic arc dermabrasion treatment was used to remove nasal telangiectasia in 23 patients. The post-treatment condition was monitored by means of phot…