Search results for "ACC"
showing 10 items of 15276 documents
CERN IRRADIATION FACILITIES.
2017
CERN provides unique irradiation facilities for applications in dosimetry, metrology, intercomparison of radiation protection devices, benchmark of Monte Carlo codes and radiation damage studies to electronics.
Sui passi della comunità: attaccamento al luogo e identità di luogo come fattori di protezione del sé
2009
Reacciones de Formación de Enlaces Carbono-Carbono y Carbono-Heteroátomo Catalizadas por Complejos de Metales de Transición
2015
La investigación en catálisis conduce al desarrollo de procesos con elevada eficacia, en términos de consumo de energía así como en producción de residuos. La utilización del sistema catalítico adecuado disminuye la energía de activación de los procesos implicados lo que permite reducir la temperatura y/o los tiempos para una determinada transformación. Los catalizadores, al modificar las barreras energéticas de las diferentes vías de reacción posibles, puede dar lugar a cambios en la selectividad de dichas transformaciones, al modificar las barreras energéticas de las diferentes vías de reacción posibles y por tanto pudiendo mejorar o incluso invertir la proporción de productos obtenida. L…
Dexamethasone premedication suppresses vaccine-induced immune responses against cancer
2020
ABSTRACT Glucocorticosteroids (GCS) have an established role in oncology and are administered to cancer patients in routine clinical care and in drug development trials as co-medication. Given their strong immune-suppressive activity, GCS may interfere with immune-oncology drugs. We are developing a therapeutic cancer vaccine, which is based on a liposomal formulation of tumor-antigen encoding RNA (RNA-LPX) and induces a strong T-cell response both in mice as well as in humans. In this study, we investigated in vivo in mice and in human PBMCs the effect of the commonly used long-acting GCS Dexamethasone (Dexa) on the efficacy of this vaccine format, with a particular focus on antigen-specif…
Eukaryotic rRNA Modification by Yeast 5-Methylcytosine-Methyltransferases and Human Proliferation-Associated Antigen p120.
2015
International audience; Modified nucleotide 5-methylcytosine (m(5)C) is frequently present in various eukaryotic RNAs, including tRNAs, rRNAs and in other non-coding RNAs, as well as in mRNAs. RNA: m(5)C-methyltranferases (MTases) Nop2 from S. cerevisiae and human proliferation-associated nucleolar antigen p120 are both members of a protein family called Nop2/NSUN/NOL1. Protein p120 is well-known as a tumor marker which is over-expressed in various cancer tissues. Using a combination of RNA bisulfite sequencing and HPLC-MS/MS analysis, we demonstrated here that p120 displays an RNA:m(5)C-MTase activity, which restores m(5)C formation at position 2870 in domain V of 25S rRNA in a nop2 Delta …
Voice traffic bicasting enhancements in mobile HSPA network
2014
This paper discusses methods for improving the effectiveness of delivering voice traffic over High-Speed Downlink Packet Access (HSDPA) network by employing transmission diversity with Single-Frequency Dual-Cell (SF-DC) Aggregation that is part of the Multiflow specification. SF-DC Aggregation allows the user to be served at the same time by two different cells. The enhancements discussed in the paper capitalize strongly on the availability of the composed Channel Quality Indication (CQI) feedback at both serving cells. According to the results obtained from the network simulations, the ability to select the better channel for each voice transmission significantly decreases the required tra…
Anomaly detection approach to keystroke dynamics based user authentication
2017
Keystroke dynamics is one of the authentication mechanisms which uses natural typing pattern of a user for identification. In this work, we introduced Dependence Clustering based approach to user authentication using keystroke dynamics. In addition, we applied a k-NN-based approach that demonstrated strong results. Most of the existing approaches use only genuine users data for training and validation. We designed a cross validation procedure with artificially generated impostor samples that improves the learning process yet allows fair comparison to previous works. We evaluated the methods using the CMU keystroke dynamics benchmark dataset. Both proposed approaches outperformed the previou…
Rehearsing to control depressive symptoms through a behavior change support system
2013
Depressive symptoms are generally coupled with distress and high treatment costs. We present our on-going research on a Web-based behavior change support system, which utilizes Acceptance and Commitment Therapy as a rehearsal tool. We present a summarized account of the research setting, studied persuasive software features, and a brief account of initial data analysis. Our work presents implications on design interventions for mental well-being and human-computer interaction.
Anomaly Detection Algorithms for the Sleeping Cell Detection in LTE Networks
2015
The Sleeping Cell problem is a particular type of cell degradation in Long-Term Evolution (LTE) networks. In practice such cell outage leads to the lack of network service and sometimes it can be revealed only after multiple user complains by an operator. In this study a cell becomes sleeping because of a Random Access Channel (RACH) failure, which may happen due to software or hardware problems. For the detection of malfunctioning cells, we introduce a data mining based framework. In its core is the analysis of event sequences reported by a User Equipment (UE) to a serving Base Station (BS). The crucial element of the developed framework is an anomaly detection algorithm. We compare perfor…
Schemata, Acculturation, and Cognition : Expatriates in Japan's Software Industry
2016
This multiple case based empirical study expands the knowledge around North American software and IT workers in Japan as well as the expatriate literature and discussion of cognitive schemata in cross cultural settings. The study includes eleven individuals, nine of them in software. Evidence of selection, rejection, and adjustment of cognitive schemata found in Japan's business world is presented. Changes in schemata drive cultural adjustment and acculturation. North American software and IT workers in Japan must maneuver through unfamiliar and often complex schemata to motivate, lead, manipulate, and communicate with coworkers and partners and thereby gain success.