Search results for "ACL"

P(HPMA)-block-P(LA) copolymers in paclitaxel formulations: Polylactide stereochemistry controls micellization, cellular uptake kinetics, intracellula…

2012

In order to explore the influence of polymer microstructure and stereochemistry in biological settings, the synthesis, micellization, cellular fate and the use in paclitaxel formulations of poly(N-(2-hydroxypropyl)-methacrylamide)-block-poly(L-lactide) (P(HPMA)-block-P(LLA)) and poly(N-(2-hydroxypropyl)-methacrylamide)-block-poly(DL-lactide) block copolymers (P(HPMA)-block-P(DLLA)) were studied. To this end, P(HPMA)-block-P(lactide) block copolymers and their fluorescently labeled analogues were synthesized. The polymers exhibited molecular weights M-n around 20,000 g/mol with dispersities (D=M-w/M-n) below 1.3. In addition, the solution conformation of this new type of partially degradable…

Cytotoxic activity of some natural and synthetic guaianolides

2005

Several natural guaianolides and synthetic derivatives of repin (1) were tested and found to be active against tumor cell replication. Repin (1) and both mono- and di-halohydrin analogues (2, 7-9, 11, 12) showed significant antitumor potency. A more effective compound (17) was obtained by esterificating repin with the paclitaxel side chain.

Pakalpojumu orientētas arhitektūras pielietojums uzņēmuma sistēmu integrācijā

2015

Implementējot SOA risinājumus, uzņēmumiem bieži nākas saskarties ar vairākām problēmām, sākot no tehniskās realizācijas līdz kļūdainām darījuma prasībām. No tām palīdzēs izvairīties pirms un pēc implementācijas analīze, kas tika definēta maģistra darbā. Maģistra darbā tiks apskatīta un analizēta servisu orientētas arhitektūras (SOA) pieeja sistēmu integrācija. Darbs satur SOA teorētisko raksturojumu, SOA analīzes metodoloģiju pirms un pēc implementācijā un reālas SOA implementācijas analīzi. Analizētā SOA tiek realizēta uz Oracle SOA platformas, izmantojot Oracle AIA (Application Integration Architecture) integrācijas ietvaru, analīze tika balstīta uz autora apkopotu metodoloģiju. Darba mēr…

Three intercontinental disjunctions in Papaveraceae subfamily Chelidonioideae: evidence from chloroplast DNA

1995

An RFLP analysis of the chloroplast genome of Papaveraceae subfam. Chelidonioideae resulted in one most parsimonious tree consisting of three monophyletic groups. Each group contains intercontinental disjunct taxa. Whereas Eomecon/Sanguinaria and Stylophorum are examples for the well known E Asian — eastern N American disjunction, the E Asian -C and S American disjunction in Macleaya/Bocconia is rare. The genus Stylophorum in this analysis is paraphyletic. The N American Stylophorum diphyllum is sister group to the Old World members of Stylophorum and Chelidonium. All American representatives of the subfamily possess distinctive morphological features. This might be the result of Tertiary a…

Towards a Genealogy of the Metaphysics of Sight: Seeing, Hearing, and Thinking in Heraclitus and Parmenides

2015

Assessment of maximal handgrip strength: how many attempts are needed?

2017

© 2017 The Authors. Background: Handgrip strength (HGS) is used to identify individuals with low muscle strength (dynapenia). The influence of the number of attempts on maximal HGS is not yet known and may differ depending on age and health status. This study aimed to assess how many attempts of HGS are required to obtain maximal HGS. Methods: Three cohorts (939 individuals) differing in age and health status were included. HGS was assessed three times and explored as continuous and dichotomous variable. Paired t-test, intraclass correlation coefficients (ICC) and Bland-Altman analysis were used to test reproducibility of HGS. The number of individuals with misclassified dynapenia at attemp…

Ultrasound Imaging Evaluation of Textural Features in Athletes with Soleus Pathology—A Novel Case-Control Study

2021

Background: the aim of this study was to compare the echotexture of patients with soleus muscle injury and age matched controls. Methods: a sample of 62 athletes was recruited at the private clinic and was divided in two group: a healthy group (n=31) and a soleus pathology group whose athletes had soleus muscle injury, located in the central tendon (n=31). The muscle thickness (MTh), echointensity (EI) and echovariation (EV) were analyzed. An intra-rater reliability test (Intraclass Correlation Coefficient-ICC) was performed in order to analyze the reliability of the values of the measurements. Results: Sociodemographic variables did not show statistically significant differences (p &gt

Bibliographie de l'histoire des politiques culturelles. France, XIXe-XXe siècles

1999

National audience; L’histoire des politiques et des institutions culturelles est aujourd’hui une composante clairement identifiée de l’école historique française. Présente au sein des mises au point disciplinaires1, cette histoire n’est plus ignorée des manuels d’histoire générale. L’histoire culturelle lui accorde une attention conforme à sa place dans l’évolution de la vie culturelle nationale. Bien plus, elle bénéficie désormais de manuels spécifiques, traduction éditoriale des avancées de la recherche4. Cette bibliographie qui compte 1891 numéros

Correlation between neonatal outcomes of twins depends on the outcome : Secondary analysis of twelve randomised controlled trials

2018

ObjectiveTo estimate the magnitude of the correlation between neonatal outcomes of twins and demonstrate how this information can be used in the design of randomised controlled trials (RCTs) in women with twin pregnancies.DesignSecondary analysis of data from 12 RCTs.SettingObstetric care in multiple countries, 2004-2012.Population or sample4504 twin pairs born to women who participated in RCTs to assess treatments given during pregnancy.MethodsIntraclass correlation coefficients (ICCs) were estimated using log-binomial and linear models.Main outcome measuresPerinatal death, respiratory distress syndrome, bronchopulmonary dysplasia, intraventricular haemorrhage, necrotising enterocolitis, s…

Intra- and Interrater Reliability of Sagittal Spinopelvic Parameters on Full-Spine Radiographs in Adults With Symptomatic Spinal Disorders

2018

Background/Aims To evaluate the intra- and interrater reliability (I-IR) of sagittal spinopelvic parameters from digital full-spine plain radiographs with basic software tools in an unselected adult population with degenerative spinal complaints who were evaluated for surgery. Methods Forty-nine adult full-spine digital radiographs were measured twice by 3 independent observers, including an experienced spine surgeon, an experienced radiologist, and a resident orthopedic surgeon. Clinical picture archiving and communication system workstations and software tools were used and landmarks were set manually. The I-IR of the sagittal vertical axis (SVA), pelvic tilt (PT), pelvic incidence (PI), …