Search results for "ACTIVATION"
showing 10 items of 2079 documents
Inhibition of the mixed lymphocyte reaction by T cell vaccination
1990
Immunization with attenuated activated autoreactive T cell lines and clones induces a response in syngeneic animals which can induce protection or recovery from autoimmune disease. This process has been termed T cell vaccination. The aim of the present study was to investigate the effect of immunization with MHC-reactive T cells on the mixed lymphocyte reaction (MLR). By injecting attenuated activated T cells primed for an alloantigen, we markedly reduced the MLR in both rats and mice. This depression appeared to be mediated by active suppression; lymphoid cells from T cell-vaccinated animals suppressed the MLR responsiveness of T cells from naive animals. Suppression of the MLR was not res…
Endoribonuclease IV. A poly(A)-specific ribonuclease from chick oviduct. 1. Purification of the enzyme.
1976
A new endoribonuclease, termed endoribonuclease IV, has been described. This enzyme has been isolated from chick oviducts and purified 15 000-fold in a 25% yield nearly to homogeneity. The nuclease, which specifically degrades poly(A), forms oligonucleotides of an average chain length of 10. These (A)-10 fragments are terminated by 3'-hydroxyl and 5'-phosphate groups. The enzyme has a pH optimum at 8.7, requires Mn2+ or Mg2+ as a cofactor, and has a molecular weight of about 45 000.
Markers of endothelial activation and left ventricular hypertrophy in essential hypertension
2003
Role of the protein C receptor in cancer progression
2014
The hemostatic system plays pleiotropic roles in cancer progression by shaping the tumor microenvironment and metastatic niches through thrombin-dependent fibrin deposition and platelet activation. Expanding experimental evidence implicates coagulation protease receptors expressed by tumor cells as additional players that directly influence tumor biology. Pro-angiogenic G protein-coupled signaling of TF through protease activated receptor 2 and regulation of tumor cell and vascular integrins through ligation by alternative spliced TF are established pathways driving tumor progression. Our recent work shows that the endothelial protein C receptor (EPCR), a stem cell marker in hematopoietic, …
Angiotensin-(1-7) attenuates endothelial cell senescence via klotho and Nrf2 activation
2018
The pleiotropic effects of antiplatelet therapies
2019
Percutaneous coronary intervention is the most often used method for coronary revascularization. Stenting restores blood perfusion to ischemic areas, but it also causes mechanical disruption of the atheromatous plaque and the nearby endothelium, stimulating the activation of platelets. In a similar way, platelets are activated by thrombin exposure in the setting of plaque rupture. The interaction between platelets, oxidative stress and inflammation is an important factor determining the extent and severity of vascular dysfunction observed in these settings. Platelets activated by the vessel trauma release inflammatory and mitogenic mediators into the vascular microenvironment, activating le…
Optimization on ports activation towards energy efficient data center networks
2018
Nowadays, Internet of thing including network support (i.e. checking social media, sending emails, video conferencing) requires smart and efficient data centers to support these services. Hence, data centers become more important and must be able to respond to ever changing service requirements and application demands. However, data centers are classified as one of the largest consumers of energy in the world. Existing topologies such as ScalNet improves the data center scalability while leading to enormous amounts of energy consumption. In this paper, we present a new energy efficient algorithm for ScalNet called Green ScalNet. The proposed topology strikes a compromise between maximizing …
Evaluation of the optimal activation parameters for almond shell bio-char production for capacitive deionization
2020
Abstract A study on a possible new biomass waste to be used as electrode material for capacitive deionization (CDI) processes was performed. Raw almond shells were pyrolyzed at 800, 900 and 1000 °C and then activated through CO2. Carbon activation is used to develop porosity inside the material, increasing the specific surface area and the adsorption performances. In this work, authors tried to correlate the effects of pyrolysis and activation temperature on the ion storage capacity. Results from the desalination tests indicated that the best performance in terms of ion adsorption was obtained when the bio-char was activated at the temperature of 900 °C. Brunauer-Emmet-Teller (BET) and Barr…
THE USE OF NEUTRON ACTIVATION ANALYSIS IN THE BIOMONITORING OF TRACE ELEMENT DEPOSITION IN THE OPOLE PROVINCE
2013
Abstract The neutron activation analysis procedure was used to determine the concentration of 42 elements: Na, Mg, Al, Cl, K, Ca, Sc, V, Cr, Mn, Fe, Ni, Co, Zn, As, Se, Br, Rb, Sr, Zr, Nb, Mo, I, Ag, Cd, Sb, Ba, Cs, La, Ce, Nd, Sm, Eu, Tb, Yb, Hf, Ta, W, Au, Hg, Th, and U accumulated in mosses sampled for testing in September and October 2011 in the Opole Province (Southern Poland). Samples of different moss species were collected near the intersections of the grid lines marked on the map of the province. The distance between the points was approximately 20 km. The analysis of the results made it possible to identify the places of increased deposition of element-pollutants and to indicate t…
Characterization of a novel population of low-density granulocytes associated with disease severity in HIV-1 infection
2012
The mechanisms resulting in progressive immune dysfunction during the chronic phase of HIV infection are not fully understood. We have previously shown that arginase, an enzyme with potent immunosuppressive properties, is increased in HIV seropositive (HIV+) patients with low CD4(+) T cell counts. Here we show that the cells expressing arginase in peripheral blood mononuclear cells of HIV+ patients are low-density granulocytes (LDGs) and that whereas these cells have a similar morphology to normal-density granulocyte, they are phenotypically different. Importantly, our results reveal that increased frequencies of LDGs correlate with disease severity in HIV+ patients.