Search results for "ADH"

Inhibitory effects on mitochondrial complex I of semisynthetic mono-Tetrahydrofuran acetogenin derivatives

2003

Modifications in the terminal alpha,beta-unsaturated gamma-methyl-gamma-lactone moiety or in the alkyl chain that links this terminal gamma-lactone with the alpha,alpha'-dihydroxylated THF system of the natural mono-tetrahydrofuranic acetogenins, annonacin and annonacinone, led to the preparation of eight semisynthetic derivatives. Their inhibitory effects on mitochondrial complex I is discussed and compared with that of the classical complex I inhibitor, rotenone.

Stroke Incidence and Death in Atrial Fibrillation Patients Newly Treated with Direct Oral Anticoagulants.

2021

Amélie Gabet,1 Edouard Chatignoux,1 Clémence Grave,1 Alexandre Vallée,2 Philippe Tuppin,3 Yannick Béjot,4 Valérie Olié1 1French Public Health Agency, Saint-Maurice, France; 2Diagnosis and Therapeutic Center, Hotel Dieu, AP-HP, University Paris Descartes, Paris, France; 3General Health Insurance Scheme (Caisse Nationale d’Assurance Maladie), Paris, France; 4Dijon Stroke Registry, EA4184, University Hospital and Medical School of Dijon, University of Burgundy, Dijon, FranceCorrespondence: Amélie GabetFrench Public Health Agency, 14 rue du Val d’Osne, Saint Maurice, 94410, FranceTel +33155125164Fax…

P4571PFA-100, a test of platelet adhesion/aggregation, predicts cardiovascular events after an acute coronary syndrome and can help in the decision-m…

2019

Abstract Background The dual antiplatelet therapy (DAPT) duration is a matter of great interest among cardiologists. Because of the conflicting evidences and the necessity to balance the reduction in major cardiac events (MACE) occurrence and the risk of major bleedings after an acute coronary syndrome (ACS), there is a general consensus on prolonging DAPT on an individual basis. There is less consensus on which parameters are to be evaluated. Nowadays tests of platelet reactivity are not included in the decision-making. Few data are available on the prognostic value of aspirin response tests that are sensitive to other mediators of platelet adhesion and aggregation in vivo under flow condi…

The Bayley II test for assessing newborns at risk. Study based on samples of premature children without brain disorders and not premature children wi…

2008

Platelet Signal-Dependent Protein Synthesis

2007

Our understanding of platelet functions has been in evolution since their discovery. Blood platelets were initially observed in the middle of the 19th century by many investigators including Zimmerman in 1860, Schultze in 1865, Osler in 1874, and Hayem in 1878 (1). Studies by Bizzozero (2,3) were the first to recognize the adhesive qualities of platelets, their participation in thrombosis and leukocyte recruitment, and their role in blood coagulation. These monumental findings, which have withstood the test of time, have expanded at a remarkable rate and continue to be the primary focus of investigative research in the platelet arena (4).

Adhesion Molecules in Kidney Diseases

2010

Green composites: A brief review

2011

The rising concern towards environmental issues and, on the other hand, the need for more versatile polymer-based materials has led to increasing interest about polymer composites filled with natural-organic fillers, i.e. fillers coming from renewable sources and biodegradable. The composites, usually referred to as "green", can find several industrial applications. On the other hand, some problems exist, such as worse processability and reduction of the ductility. The use of adhesion promoters, additives or chemical modification of the filler can help in overcoming many of these limitations. These composites can be further environment-friendly when the polymer matrix is biodegradable and c…

VALUTAZIONE DELLA RESISTENZA DI ADESIONE E DELLA LUNGHEZZA EFFICACE DI INCOLLAGGIO NEI GIUNTI ADESIVI TRAMITE LE LEGGI DELL’EFFETTO SCALA

2010

In recent years, growing attention has been paid by researchers in structural mechanics to bonded joints in order to provide theoretical and numerical tools for better understanding the interfacial bonding/debonding phenomena. The research efforts in this area regard the formulation of reliable bond-slip models based on experimental data coming from laboratory tests performed on small specimens [1, 2]. As reported in [3], the mechanical quantities characterizing any interface constitutive law can be derived from the results of the experimental pull tests by a simple procedure making use of a schematization of the structural problem. The application to some single lap joint tests, carried ou…

La mesure directe des forces de liaison entre les hydrates appliquée à la prise de plâtre

1998

Le phenomene de prise est un phenomene general, observable sur tous les liants mineraux, ciments siliceux, alumineux... et le plâtre. S'il existe des lois gouvernant la prise, elles doivent s'appliquer a tous ces liants. Aussi, il peut etre justifie de prendre tel ou tel liant pour modele si cela peut simplifier la premiere approche. Ici, l'objectif est de mesurer les forces entre les grains de silicate de calcium hydrate (phase C-S-H) qui est l'hydrate le plus caracteristique des ciments courants. Ces grains sont extremement petits et il a ete choisi de mettre au point les methodes travaillant sur le plâtre qui s'hydrate sous forme de gypse en formant des cristaux de 10 a 100 fois plus gro…

Numerical simulations demonstrate that the double tapering of the spatualae of lizards and insects maximize both detachment resistance and stability

2011

Many biological attachment devices of insects, spiders and geckos consist of arrays of hairs (setae), which are terminated by contact elements of different shapes. However, the most frequently observed shape is a thin plate-like spatula. In spite of a rather wide range of sizes, most spatulae of different animals are not uniform, but rather possess a gradient in thickness and width. Here we show that the spatulae of insects and geckos become gradually thinner and wider approaching the end. This geometrical effect is explained in the present paper, by using a numerical approach for the modelling of the van der Waals adhesion and friction between the contact elements and the substrate. The ap…