Search results for "ADHERENCE"

showing 10 items of 277 documents

Adjuvant treatments for gastric cancer: From practice guidelines to clinical practice

2013

Abstract Background For gastric cancers, the benefits of adjuvant radiochemotherapy and of perioperative chemotherapy have been demonstrated since 2001 and 2006 respectively. The aim of this study was to evaluate the diffusion of adjuvant treatments in a French population. Methods 334 incident gastric cancers UICC Stage IB, II, III or IVM0 resected for cure and recorded in the Burgundy digestive cancer registry were retrospectively included. Patients were classified as having received an effective adjuvant treatment if they had been treated by adjuvant radiochemotherapy since 2001 or perioperative chemotherapy since 2006. Results The proportion of patients treated with an effective adjuvant…

MaleOncologymedicine.medical_specialtymedicine.medical_treatmentPopulationStomach NeoplasmsInternal medicineCarcinomaHumansMedicineRegistrieseducationAgedRetrospective StudiesAged 80 and overeducation.field_of_studyHepatologybusiness.industryCarcinomaGastroenterologyCancerRetrospective cohort studyChemoradiotherapy AdjuvantMiddle Agedmedicine.diseaseCancer registryRadiation therapyRegimenLogistic ModelsTreatment OutcomeChemotherapy AdjuvantMultivariate AnalysisPractice Guidelines as TopicFemaleFranceGuideline AdherencebusinessAdjuvantDigestive and Liver Disease
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Impact of recommendations on the initial therapy of Parkinson’s disease: A population-based study in France

2011

International audience; Levodopa induces long-term motor complications in Parkinson's disease (PD). Therapeutic strategies that prevent motor complications are needed. Our aim was to evaluate the impact of recommendations of a French consensus conference published in 2000 on initial PD therapy. We identified 308 PD patients as part of a population-based study performed within the Mutualité Sociale Agricole in five French districts (2007). Neurologists confirmed PD diagnosis. We compared initial therapy in 102 patients treated before 12/31/2000 to that of 206 patients treated afterwards. Initial treatment was in agreement with the recommendations if dopamine agonists were used in patients <6…

MaleParkinson's diseaseEpidemiologyConsensus Development Conferences as TopicParkinson's diseaseMESH: Antiparkinson AgentsDiseaseAntiparkinson AgentsLevodopa0302 clinical medicineMESH: Practice Guidelines as TopicEpidemiology030212 general & internal medicinePractice Patterns Physicians'Initial therapyMESH: Dopamine AgonistsMESH: AgedMESH: Levodopaeducation.field_of_studyMESH: Middle AgedConsensus conferenceParkinson DiseaseMiddle Aged3. Good healthNeurologyDopamine AgonistsPractice Guidelines as TopicMESH: Guideline AdherenceFemaleFranceGuideline Adherencemedicine.drugmedicine.medical_specialtyLevodopaPopulationGuidelines03 medical and health sciencesInternal medicineMedical practicemedicineHumansMESH: Physician's Practice PatternseducationAgedMESH: HumansMESH: Consensus Development Conferences as Topicbusiness.industrymedicine.diseaseMESH: MaleMESH: FrancePopulation based study[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologiePhysical therapy[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologieNeurology (clinical)Geriatrics and GerontologybusinessMESH: FemaleMESH: Parkinson Disease030217 neurology & neurosurgeryParkinsonism &amp; Related Disorders
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Multicentric Italian survey on daily practice for autoimmune pancreatitis: Clinical data, diagnosis, treatment, and evolution toward pancreatic insuf…

2020

BACKGROUND: Autoimmune pancreatitis (AIP) is a rare, and relatively new, form of chronic pancreatitis. The management of AIP can vary considerably among different centres in daily clinical practice. OBJECTIVES: The aim of this study is to present a picture of epidemiological, clinical characteristics, outcomes, and the real-life practice in terms of management in several academic and non-academic centres in Italy. METHODS: Data on the clinical presentation, diagnostic work-up, treatments, frequency of relapses, and long-term outcomes were retrospectively collected in a cohort of AIP patients diagnosed at 14 centres in Italy. RESULTS: One hundred and six patients were classified as type 1 AI…

MalePediatricsBiopsyAftercareAzathioprineFeces0302 clinical medicineRecurrencePrednisoneSecondary PreventionPractice Patterns Physicians'Autoimmune pancreatitisEndoscopic retrograde cholangiopancreatographyPancreatic Elastasemedicine.diagnostic_testGastroenterologyfood and beveragesMiddle AgedJaundiceItalyOncology030220 oncology & carcinogenesisFemale030211 gastroenterology & hepatologyRituximabGuideline Adherencesteroid trialmedicine.symptomRituximabImmunosuppressive Agentsmedicine.drugmedicine.medical_specialtyfine needle aspiration/biopsyNausea03 medical and health sciencesmedicineHumansGlucocorticoidsPancreasRetrospective StudiesAutoimmune pancreatitisbusiness.industryEndoscopyOriginal Articlespancreatic insufficiencymedicine.diseaseendoscopic ultrasoundPancreatitisbusinessFollow-Up StudiesUnited European Gastroenterology Journal
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Adherence to growth hormone (GH) therapy in naïve to treatment GH-deficient children: data of the Italian Cohort from the Easypod Connect Observation…

2019

Background: With the use of non-objective measurement, adherence to growth hormone (GH) therapy has been reported suboptimal in a large proportion of patients, and poor adherence has been shown to affect short-term growth response in patients receiving GH treatment. Objective: The Easypod™ electronic device allows objective measurement of adherence. In this study, we report 3-year prospective adherence data of the Italian cohort of naïve GH deficient (GHD) children extrapolated from the Easypod Connect Observational Study (ECOS) database. Patients and methods: Seventy-three GHD children naïve to GH treatment were included in the analysis. 22 Italian centers participated in the study. Result…

MalePediatricsDatabases FactualChildren; ECOS; GHD; Growth hormone; Short statureEndocrinology Diabetes and MetabolismChildren; ECOS; GHD; Growth hormone; Short stature;Children; ECOS; GHD; Growth hormone; Short stature; Adolescent; Child; Cohort Studies; Databases Factual; Dwarfism Pituitary; Female; Growth Disorders; Human Growth Hormone; Humans; Italy; Male; Medication Adherence; Telemedicine; Medical Records Systems Computerized; Wearable Electronic DevicesGrowth hormoneCohort Studies0302 clinical medicineEndocrinologyChildChildrenGrowth DisordersHuman Growth HormoneChildren ECOS GHD Growth hormone Short statureObjective measurementSettore MED/38TelemedicineItaly030220 oncology & carcinogenesisCohortFemaleOriginal ArticleMedical Records Systemsmedicine.symptomCohort studymedicine.medical_specialtyAdolescentMedical Records Systems ComputerizedDwarfism030209 endocrinology & metabolismShort statureMedication AdherenceDatabasesWearable Electronic Devices03 medical and health sciencesmedicineHumansIn patientDwarfism PituitaryGrowth hormoneFactualbusiness.industryComputerizedShort staturePituitaryGh treatmentECOSObservational studybusinessGHDJournal of Endocrinological Investigation
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Comparing Long-Acting Antipsychotic Discontinuation Rates Under Ordinary Clinical Circumstances: A Survival Analysis from an Observational, Pragmatic…

2021

Background Recent guidelines suggested a wider use of long-acting injectable antipsychotics (LAI) than previously, but naturalistic data on the consequences of LAI use in terms of discontinuation rates and associated factors are still sparse, making it hard for clinicians to be informed on plausible treatment courses. Objective Our objective was to assess, under real-world clinical circumstances, LAI discontinuation rates over a period of 12 months after a first prescription, reasons for discontinuation, and associated factors. Methods The STAR Network ‘Depot Study’ was a naturalistic, multicentre, observational prospective study that enrolled subjects initiating a LAI without restrictions …

MalePediatricsrespectively)0302 clinical medicineDelayed-Action PreparationBrief Psychiatric Rating ScalePharmacology (medical)he STAR Network ‘Depot Study’ prospectively followed 394 subjects initiating treatment with long-acting injections (LAIs) of antipsychotics under naturalistic conditions for 12 months. LAI discontinuation was frequent in everyday clinical practice in ItalyOriginal Research ArticleProspective StudiesProspective cohort studytreatmentMental DisordersHazard ratiowhereas more than half of participants initiating risperidone LAI and olanzapine LAI discontinued during the 12 months of follow-up (51.4 and 62.5%Psychiatric Status Rating ScaleMiddle Agedside efectsPsychiatry and Mental healthItalyMental DisorderFemalehe STAR Network ‘Depot Study’ prospectively followed 394 subjects initiating treatment with long-acting injections (LAIs) of antipsychotics under naturalistic conditions for 12 months. LAI discontinuation was frequent in everyday clinical practice in Italy occurring in almost 40% of the entire sample; side efects participant refusal to continue LAIs and LAIs no longer being required were the most frequently reported reasons for discontinuation. Paliperidone LAI and aripiprazole LAI were the least discontinued medications (33.9 and 35.4% respectively) whereas more than half of participants initiating risperidone LAI and olanzapine LAI discontinued during the 12 months of follow-up (51.4 and 62.5% respectively). In multivariate analysis being prescribed olanzapine LAI and poor medication adherence at baseline were signifcantly associated with higher discontinuation risk.HumanAntipsychotic Agentsmedicine.drugPsychopathologyAdultmedicine.medical_specialtyDiscontinuationFollow-Up StudieMedication Adherence03 medical and health sciencesmedicineHumansPaliperidoneAdverse effectSettore MED/25 - Psichiatriadiscontinuation ratesPsychiatric Status Rating Scalesrespectively). In multivariate analysisbusiness.industryLong-Acting Antipsychoticlong-acting injectable antipsychoticsSurvival AnalysisConfidence intervalparticipant refusal to continue LAIs and LAIs no longer being required were the most frequently reported reasons for discontinuation. Paliperidone LAI and aripiprazole LAI were the least discontinued medications (33.9 and 35.4%030227 psychiatryDiscontinuationProspective StudieAntipsychotic Agentoccurring in almost 40% of the entire sampleDelayed-Action PreparationsNeurology (clinical)business030217 neurology & neurosurgerybeing prescribed olanzapine LAI and poor medication adherence at baseline were signifcantly associated with higher discontinuation riskFollow-Up Studies
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Clusters of sleep apnoea phenotypes: A large pan-European study from the European Sleep Apnoea Database (ESADA)

2021

Background and objective: To personalize OSA management, several studies have attempted to better capture disease heterogeneity by clustering methods. The aim of this study was to conduct a cluster analysis of 23 000 OSA patients at diagnosis using the multinational ESADA. Methods: Data from 34 centres contributing to ESADA were used. An LCA was applied to identify OSA phenotypes in this European population representing broad geographical variations. Many variables, including symptoms, comorbidities and polysomnographic data, were included. Prescribed medications were classified according to the ATC classification and this information was used for comorbidity confirmation. Results: Eight cl…

MalePulmonary and Respiratory MedicineDatabases FactualTreatment adherenceinternational databaseComorbidityDiseasecomputer.software_genre03 medical and health sciencesSleep Apnea Syndromes0302 clinical medicinePan europeanHumansMedicinecluster analysis ; international database ; personalized medicine ; phenotypes ; sleep apnoea.030212 general & internal medicineMedical prescriptionPrescribed medicationsComputingMilieux_MISCELLANEOUSSleep Apnea Obstructive[STAT.AP]Statistics [stat]/Applications [stat.AP]Databasebusiness.industryphenotypesEuropean populationpersonalized medicinemedicine.diseaseComorbidity3. Good healthPhenotype030228 respiratory systemFemalePersonalized medicinebusinesscomputersleep apnoea[SDV.MHEP]Life Sciences [q-bio]/Human health and pathologycluster analysis
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Inhalation therapy in the next decade

2018

This article is distributed under the terms of the Creative Commons Attribution Noncommercial License (by-nc 4.0) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

MalePulmonary and Respiratory Medicinemedicine.medical_specialtyRespiratory TherapyEuropean Seminars in Respiratory MedicineCost-Benefit Analysiseducationlcsh:MedicineMedication adherenceSettore MED/10 - Malattie Dell'Apparato RespiratorioCOPD; European Seminars in Respiratory Medicine; Inhalation therapyINSPIRATORY FLOW-RATEHistory 21st CenturyOBSTRUCTIVE PULMONARY-DISEASEPulmonary Disease Chronic ObstructivePATIENT ADHERENCECOPD; European Seminars in Respiratory Medicine; Inhalation therapy; Pulmonary and Respiratory MedicineITALIAN GENERAL-PRACTITIONERSmedicinePulmonary MedicineHumansCOPDMortalityMEDICATION ADHERENCEIntensive care medicineAsthmaHEALTH-CARE PROFESSIONALSCOPDInhalationbusiness.industryDRY POWDER INHALERlcsh:ROBJECTIVELY IDENTIFIED COMORBIDITIESIMPROVES LUNG-FUNCTIONHistory 20th Centurymedicine.diseaseDry-powder inhalerAsthmarespiratory tract diseasesRespiratory MedicineREAL-LIFEItalyInhalation therapyFemaleCardiology and Cardiovascular MedicinebusinessMonaldi Archives for Chest Disease
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Genuair® Usability Test: Results of a National Public Survey of the Elderly

2016

Proper use of inhaler devices may be problematic in elderly patients due to age-related difficulties. A survey was administered to elderly patients to investigate the usability of the Genuair® device and patients' subjective viewpoint on the device. A representative sample of the Italian population aged ≥ 65 years was completed with a pre-defined sample of 89 patients with hand arthritis/arthrosis. Of 526 respondents, 88 were not self-sufficient. Only the replies of the 438 self-sufficient respondents were analyzed. A total of 107 participants (24%) reported having respiratory diseases, and 81 of these (76%) were users of inhaler devices. After the first test, the device was considered “pra…

MalePulmonary and Respiratory Medicinemedicine.medical_specialtyTime FactorsSample (statistics)Settore MED/10 - Malattie Dell'Apparato Respiratorioelderly03 medical and health sciences0302 clinical medicinePatient satisfactionPatient Education as TopicSurveys and QuestionnairesmedicineHumansadherence030212 general & internal medicineAgedAged 80 and overbusiness.industryArthritisNebulizers and VaporizersInhalerUsabilityPublic surveyadherence; elderly; inhaler device; usability; Pulmonary and Respiratory MedicineHandItalian populationTest (assessment)usabilityItaly030228 respiratory systemPatient SatisfactionHand arthritisPhysical therapyinhaler deviceFemalebusinessCOPD: Journal of Chronic Obstructive Pulmonary Disease
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Ten years' experience with an external quality control program for semen analysis

2012

To gauge the performance of laboratories and impact of the German semen analysis external quality control program (QuaDeGA) over its first 10 years.Retrospective analysis of QuaDeGA's twice yearly distribution of fixed semen samples and electronic material documenting sperm motility. Ranking of each participant's responses was determined according to their relation to a "target window."Multicenter. PAITENT(S): Healthy donors.None.Laboratory performance, World Health Organization (WHO) adherence.Over 19 runs, there was a steady increase of participants (280 laboratories), the largest group being private urologic practices. Although use of WHO-recommended Neubauer chamber (from 33% to 55%) an…

MaleQuality Controlmedicine.medical_specialtySperm Countmedicine.diagnostic_testbusiness.industryOutcome measuresObstetrics and GynecologyQuality controlSemenSemen analysisWorld Health OrganizationWorld healthSemen AnalysisAndrologyWho recommendationsReproductive MedicineFamily medicineRetrospective analysisHumansMedicineGuideline AdherencebusinessQuality assuranceRetrospective StudiesFertility and Sterility
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Adherence to immunomodulatory drugs in patients with multiple myeloma

2018

Background Immunomodulatory drugs (thalidomide, lenalidomide and pomalidomide; IMID) are widely used in the treatment of multiple myeloma patients. To date, few data are available on IMID adherence in multiple myeloma patients. The aim of our study was to evaluate IMID adherence and to compare two indirect methods to measure IMID adherence in multiple myeloma patients: a specific questionnaire and the medication possession ratio (MPR). Another aim was to explore this specific questionnaire for the assessment of IMID adherence in multiple myeloma patients. Methods All consecutive multiple myeloma patients, with at least two consecutive dispensations of thalidomide, lenalidomide or pomalidomi…

MaleQuestionnairesCancer Treatment030204 cardiovascular system & hematologyPharmacistsPlasma Cell DisordersHematologic Cancers and Related DisordersMathematical and Statistical Techniques0302 clinical medicineSurveys and QuestionnairesMedicine and Health SciencesMedical PersonnelProspective StudiesProspective cohort studyMultiple myelomaMultidisciplinaryQStatisticsRHematologyMyelomasProfessionsOncologyResearch Design030220 oncology & carcinogenesisPhysical SciencesMedicineRegression AnalysisFemaleMultiple MyelomaResearch Articlemedicine.drugmedicine.medical_specialtyDrug AdherenceClinical Research DesignScienceLinear Regression AnalysisResearch and Analysis MethodsMedication Adherence03 medical and health sciencesCronbach's alphaInternal medicinemedicineHumansImmunologic FactorsIn patientMyelomas and Lymphoproliferative DiseasesStatistical MethodsAdverse effectAgedLenalidomidePharmacologySurvey Researchbusiness.industryCancers and NeoplasmsPomalidomidemedicine.diseaseThalidomidePeople and PlacesPopulation GroupingsAdverse EventsbusinessMathematicsPLOS ONE
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