Search results for "ADP"
showing 10 items of 423 documents
Thrombophilic genetic factors PAI-1 4G-4G and MTHFR 677TT as risk factors of alcohol, cryptogenic liver cirrhosis and portal vein thrombosis, in a Ca…
2015
The thrombophilic genetic factors (THRGFs), PAI-1 4G-4G, MTHFR 677TT, V Leiden 506Q and Prothrombin 20210A, were studied as risk factors in 865 Caucasian patients with liver cirrhosis, consecutively enrolled from June 2008 to January 2014. A total of 582 HCV, 80 HBV, 94 alcohol, (82 with more than one etiologic factor) and 191 cryptogenic patients with liver cirrhosis had been consecutively enrolled; 243 patients showed portal vein thrombosis (PVT). At least one of the above THRGFs was present in 339/865 patients (39.2%). PAI-1 4G-4G and MTHFR 677TT were the most frequent THRGFs, statistically significant in patients with alcohol, cryptogenic liver cirrhosis, and PVT: respectively 24 and 28…
Līvānu novada Centrālās bibliotēkas novadpētniecības darba virzieni
2015
Mūsdienu bibliotēka vairs nav tikai informācijas centrs, bet tā pilda arī kultūras un sociālo aktivitāšu centra funkcijas. Novadpētniecība, kā bibliotēku darba virziens, mūsdienās kļūst arvien populārāks, jo tas ne tikai saliedē vietējo kopienu un rada piederības sajūtu kādai noteiktai vietai, bet arī saglabā, popularizē un padara pieejamu vēsturisko materiālu. Pētījuma mērķis ir noskaidrot, kādi ir novadpētniecības darba virzieni Līvānu novada Centrālajā bibliotēkā. Pētījumā izmantoti tiek Līvānu novada Centrālās bibliotēkas ikgadējie pārskati no 2010. – 2014. gadam. Lai iegūtu padziļinātāku viedokli par novadpētniecības darbu ir veiktas arī intervijas, kuras atklāj novadpētniecības, kā bi…
Rudes ciems un Roja iedzīvotāju atmiņu stāstos un publikācijās
2018
Novadpētniecība mūsdienās paliek ar vien aktuālāka. Cilvēkam kā indivīdam liekas interesanti uzzināt interesantus faktus par sava novada, ciema vai pilsētas vēsturi. Ar mutvārdu vēstures palīdzību, šos faktus iespējams atklāt no jauna, pavisam ar citu redzējumu. Pētījuma mērķis ir ar mutvārdu vēstures liecībām un publikāciju kontentanalīzi izpētīt un izprast dzīvi Rudes ciemā un Rojā 20. gadsimta 60.- 90. gados. Pētījuma gaitā veiktas intervijas ar Rojas novada iedzīvotājiem un veikta 18 publikāciju kontentanalīze, lai pēc iespējas vairāk uzzinātu par tā laika dzīvi. Pētījuma rezultāti parāda, ka cilvēkiem dzīve nav bijusi smaga vai grūta. Visiem astoņiem respondentiem dzīve kolhozā likusie…
Gp91phox-containing NAD(P)H oxidase increases superoxide formation by doxorubicin and NADPH
2006
Doxorubicin is a highly effective antineoplastic drug associated with a dose-dependent cardiotoxicity that may result in irreversible cardiomyopathy and heart failure. Gene variants of the superoxide-generating enzyme NAD(P)H oxidase have recently been associated with this phenotype. We investigated the mechanism of this association using lucigenin-enhanced chemiluminescence, spectrophotometry, electrochemical sensor, and electron paramagnetic resonance spectroscopy. Superoxide production was measured in female wild-type and NAD(P)H oxidase-deficient (gp91phox knockout) mice. The magnitude of the increase in superoxide production on the addition of doxorubicin was much higher in hearts of w…
Can PBDEs affect the pathophysiologic complex of epithelium in lung diseases?
2020
Brominated flame-retardant (BFRs) exposure promotes multiple adverse health outcomes involved in oxidative stress, inflammation, and tissues damage. We investigated BFR effects, known as polybrominated diphenyl ethers (PBDEs) (47, 99 and 209) in an air-liquid-interface (ALI) airway tissue derived from A549 cell line, and compared with ALI culture of primary human bronchial epithelial cells (pHBEC). The cells, exposed to PBDEs (47, 99 and 209) (0.01-1 mu M) for 24 h, were studied for IL-8, Muc5AC and Muc5B (mRNAs and proteins) production, as well as NOX-4 (mRNA) expression. Furthermore, we evaluated tight junction (TJ) integrity by Trans-Epithelial Electrical Resistance (TEER) measurements, …
CD38 expression enhances sensitivity of lymphoma T and B cell lines to biochemical and receptor-mediated apoptosis
2006
CD38 has been widely characterised both as an ectoenzyme and as a receptor. In the present paper, we investigated the role of CD38 as possible modulator of apoptosis. CD38-positive (CD38(+)) and negative (CD38(-)) fractions, obtained by sorting CD38(+) cells from lymphoma T (Jurkat) and lymphoma B (Raji) and by transfecting lymphoma LG14 and myeloid leukemia K562 cell lines, were used. Cellular subpopulations were exposed to different triggers (H(2)O(2), UV-B, alpha-TOS and hrTRAIL) and the extent of apoptosis was determined by Annexin V-FITC/PI assay. Our data showed that, in lymphoma cells, propensity to apoptosis was significantly linked to CD38 expression and that, remarkably, such resp…
Līvānu stikla fabrikas vēsture no 1970. gada līdz 1995. gadam
2019
Bakalaura darba temats ir “Līvānu stikla fabrikas vēsture no 1970. gada līdz 1995. gadam”. Šī bakalaura darba galvenais mērķis ir apkopot informāciju par Līvānu stikla fabriku dokumentos, publikācijas un mutvārdu vēstures stāstos laika posmā no 1975. gada līdz 1992. gadam un salīdzināt galvenos procesus un notikumus, kas notikuši fabrikas vēsturē. Tā rezultātā noskaidrot Līvānu stikla fabrikas nozīmi. Pētījuma rezultātā tapis bakalaura darbs, kur tika izpētīta un apzināta informācija par Līvānu stikla fabriku, tās vēsturi, galvenajiem attīstības posmiem, sabiedrisko dzīvi un norieta periodu. Pētījumā izmantoti Līvānu novada Centrālās bibliotēkās pieejamie novadpētniecības materiāli. Padziļi…
Effect of oxidative stress on UDP-glucuronosyltransferases in rat astrocytes.
2012
WOS:000309170300003; International audience; The present work reports data regarding effects of an induced oxidative stress on the mainly expressed isoforms of UDP-glucuronosyltransferases (UGTs) in the brain. UGT1A6 and UGT1A7 expression and enzymatic activities toward the 1-naphthol were analyzed in rat cultured astrocytes following the exposure for 48 h to redox-cycling xenobiotic compounds such as quinones and bipyridinium ions. The expression of NADPH:cytochrome P450 reductase and NAD(P)H:quinone oxidoreductase 1 (NQO1) was also investigated. Oxidative stress induced significant deleterious changes in astrocyte morphology, decreased cell viability and inhibited catalytic function of UG…
Early mitochondrial dysfunction, superoxide anion production, and DNA degradation are associated with non-apoptotic death of human airway epithelial …
2002
It has been shown that bacterial exoproducts may induce airway epithelium injury. During the epithelial repair process, the respiratory epithelial cells no more establish tight junctional intercellular complexes and may be particularly susceptible to bacterial virulence factors. In this study, we analyzed the effect of Pseudomonas aeruginosa exotoxin A (ETA) at different periods of time and concentrations on 16 HBE 14o(-) human bronchial epithelial cells in culture conditions inducing a phenotype of repairing cells. ETA treatment for 24 and 48 h led to the killing of 40.0 +/- 5.7% and 79.0 +/- 1.4% of the cells, respectively, as determined by the dimethylthiazole 2,5 diphenyl tetrazolium br…
Circumdatin H, a new inhibitor of mitochondrial NADH oxidase, from Aspergillus ochraceus
2005
Circumdatin H (1), a new alkaloid from the culture broth of Aspergillus ochraceus, has been isolated, together with a known circumdatin, circumdatin E (2) and other known compounds: flavacol (3) and stephacidin A (4). The structure of 1 was established on the basis of chemical and spectral evidence. All of these alkaloids showed biological activity as inhibitors of the mammalian mitochondrial respiratory chain.