Search results for "ADR"

Replication of herpes simplex virus type 1 and 2 in the medulla of the adrenal gland after vaginal infection of mice.

1996

After vaginal infections of mice with neuroinvasive strains of herpes simplex virus type 1 and 2 (HSV-1, HSV-2) virus replicates in the epithelium of the vagina, in the paravaginal ganglia, in the spinal cord and finally in the brain and in the adrenal glands. However, viral antigens could be demonstrated only in the medulla of the adrenal glands but not in the cortex, as assessed by immunohistochemistry (IHC). HSV could not be isolated from liver, spleen, uterus, and ovaries. This contrasts to the intraperitoneal (i.p) route of infection with replication in different visceral organs including the adrenal gland's cortex.

Colonization of adrenal glands and ovaries of mice by variants of HSV 1 and 2

1991

The herpes simplex virus (HSV)-infected mouse model was used to correlate histopathological lesions in adrenal glands and ovaries with the localisation of viral nucleic acids and viral antigens, employing in situ hybridization and immunohistochemistry. In the adrenals, the lesions were mainly restricted to the zona fasciculata and the zona reticularis, sometimes extending to the medulla. In the ovaries, lesions were detected in follicles and in the stroma. During the course of infection, HSV nucleic acids could be detected earlier than HSV proteins. Next to the center of necrotic foci mainly HSV proteins were detected, whereas peripheral cells were found to contain viral nucleic acids. In s…

The ALICE experiment at the CERN LHC

2008

Journal of Instrumentation 3(08), S08002 (2008). doi:10.1088/1748-0221/3/08/S08002

Few-body insights of multiquark exotic hadrons

2018

In this contribution we discuss the adequate treatment of the $4-$ and $5-$body dynamics within a constituent quark framework. We stress that the variational and Born-Oppenheimer approximations give energies rather close to the exact ones, while the diquark approximation might be rather misleading. Hall-Post inequalities provide very useful lower bounds that exclude possible stable states for some mass ratios and color wave functions.

The Large Observatory For x-ray Timing

2014

The Large Observatory For x-ray Timing (LOFT) was studied within ESA M3 Cosmic Vision framework and participated in the final down-selection for a launch slot in 2022-2024. Thanks to the unprecedented combination of effective area and spectral resolution of its main instrument, LOFT will study the behaviour of matter under extreme conditions, such as the strong gravitational field in the innermost regions of accretion flows close to black holes and neutron stars, and the supra-nuclear densities in the interior of neutron stars. The science payload is based on a Large Area Detector (LAD, 10 m 2 effective area, 2-30 keV, 240 eV spectral resolution, 1 deg collimated field of view) and a WideFi…

K∗(892)0 and φ(1020) production in p-Pb collisions at √sNN = 8.16 TeV

2023

The production of K∗(892)0 and ϕ(1020)resonances has been measured in p-Pb collisions at √sNN = 8.16 TeV using the ALICE detector. Resonances are reconstructed via their hadronic decay channels in the rapidity interval −0.5 8 GeV/c), the RpPb values of all hadrons are consistent with unity within uncertainties. The RpPb of K∗(892)0and ϕ(1020)at √sNN = 8.16 and 5.02 TeV show no significant energy dependence. peerReviewed

Observation of flow angle and flow magnitude fluctuations in Pb-Pb collisions at √sNN = 5.02 TeV at the CERN Large Hadron Collider

2023

This Letter reports on the first measurements of transverse momentum dependent flow angle Ψn and flow magnitude vn fluctuations determined using new four-particle correlators. The measurements are performed for various centralities in Pb–Pb collisions at a center-of-mass energy per nucleon pair of √SNN = 5.02 TeV with ALICE at the CERN Large Hadron Collider. Both flow angle and flow magnitude fluctuations are observed in the presented centrality ranges and are strongest in the most central collisions and for a transverse momentum pT>2GeV/c. Comparison with theoretical models, including iEBE-VISHNU, MUSIC, and AMPT, show that the measurements exhibit unique sensitivities to the initial state…

Verzeichnis d. Rigaer-Aerzte

1931

An arthritogenic alphavirus uses the α1β1 integrin collagen receptor

2005

Ross River (RR) virus is an alphavirus endemic to Australia and New Guinea and is the aetiological agent of epidemic polyarthritis or RR virus disease. Here we provide evidence that RR virus uses the collagen-binding alpha1beta1 integrin as a cellular receptor. Infection could be inhibited by collagen IV and antibodies specific for the beta1 and alpha1 integrin proteins, and fibroblasts from alpha1-integrin-/- mice were less efficiently infected than wild-type fibroblasts. Soluble alpha1beta1 integrin bound immobilized RR virus, and peptides representing the alpha1beta1 integrin binding-site on collagen IV inhibited virus binding to cells. We speculate that two highly conserved regions with…

NT-3 in cardiovascular pathologies

2019

La NT-3 y su receptor TrkC son puntos clave en la formación del corazón y los vasos durante la etapa embrionaria. Sin embargo, el papel de la NT-3 como modulador de las funciones cardiovasculares en la edad adulta no ha sido investigado con detalle. El objetivo de la presente Tesis es determinar la expresión de NT-3 y TrkC en el sistema cardiovascular humano y de roedores, así como el papel de la vía NT-3/TrkC como moduladora de las funciones cardiovasculares y su relación con las enfermedades a este nivel. Para ello, se cuantificó la expresión génica y proteica de NT-3 y TrkC, en tejidos humanos y de roedores, así como en células humanas cardiacas y aorticas. Los resultados muestran que lo…