6533b7d1fe1ef96bd125cc1b

RESEARCH PRODUCT

Replication of herpes simplex virus type 1 and 2 in the medulla of the adrenal gland after vaginal infection of mice.

Jürgen PodlechDietrich FalkeF. HengererM FleckIwan Walev

subject

virusesHerpesvirus 2 HumanUterusSpleenHerpesvirus 1 HumanBiologymedicine.disease_causeVirus ReplicationHerpesviridaeVirusMiceVirologyChlorocebus aethiopsmedicineAnimalsHumansAntigens ViralVero CellsMedullaCerebral CortexMice Inbred BALB CAdrenal glandGeneral MedicineVirologymedicine.anatomical_structureHerpes simplex virusSpinal CordAdrenal MedullaVaginaVaginaFemale

description

After vaginal infections of mice with neuroinvasive strains of herpes simplex virus type 1 and 2 (HSV-1, HSV-2) virus replicates in the epithelium of the vagina, in the paravaginal ganglia, in the spinal cord and finally in the brain and in the adrenal glands. However, viral antigens could be demonstrated only in the medulla of the adrenal glands but not in the cortex, as assessed by immunohistochemistry (IHC). HSV could not be isolated from liver, spleen, uterus, and ovaries. This contrasts to the intraperitoneal (i.p) route of infection with replication in different visceral organs including the adrenal gland's cortex.

yearjournalcountryeditionlanguage
1996-10-01Archives of virology
10.1007/bf01718210https://pubmed.ncbi.nlm.nih.gov/8920831