Search results for "ADT"

Kampania wielkopolska i kujawska Chryzostoma Jana Niemiry Gniazdowskiego

2020

W pracy przedstawiony został przebieg kampanii wielkopolsko-kujawskiej, która trwała dziewięć miesięcy, od lutego do października 1716 r. Przyjętym przez tarnogrodzian celem było rozszerzenie związku konfederackiego na Wielkopolskę właściwą, a następnie Kujawy i Pomorze. Poprowadzona została przez regimentarza, pułkownika Chryzostoma Jana Niemirę Gniazdowskiego - jeśli nie najzdolniejszego, to niewątpliwe najbardziej rzutkiego, skorego do podejmowania ryzykownych akcji, a przy tym skutecznego dowódcę konfederackiego. Jego przeciwnikiem były wojska królewskie złożone z oddziałów saski i polskich, dowodzone przez generała porucznika Kaspra von Seidlitz oraz generałów majorów Aleksandra Dietri…

Translational readthrough of ciliopathy genes BBS2 and ALMS1 restores protein, ciliogenesis and function in patient fibroblasts

2021

Abstract Background Ciliary dysfunction underlies a range of genetic disorders collectively termed ciliopathies, for which there are no treatments available. Bardet-Biedl syndrome (BBS) is characterised by multisystemic involvement, including rod-cone dystrophy and renal abnormalities. Together with Alstrom syndrome (AS), they are known as the ‘obesity ciliopathies’ due to their common phenotype. Nonsense mutations are responsible for approximately 11% and 40% of BBS and AS cases, respectively. Translational readthrough inducing drugs (TRIDs) can restore full-length protein bypassing in-frame premature termination codons, and are a potential therapeutic approach for nonsense-mediated ciliop…

Operu repertuārs no 1888. gada aprīļa līdz 1914. gada maijam

1888

Beitrag zur Gebäude-Statistik der Stadt Riga für das Jahr 1866

1868

Vorwort. I. Capitel. Die Zahl und Nutzung der Gebäude II. Capitel. Der Besitzstand der Gebäude III. Die Besteuerung der Gebäude IV. Capitel. Die Wohnungen. Anhang 1. Instruction zur Abschätzung sämmtlicher Immobilien im Polizeibezirk der Stadt Riga. Anhang 2. Uebersicht über die nach Zimmerzahl, Höhenlage und Miethzins gegliederten Wohnungen, Buden und Kellerräume in den einzelnen Quartalen der Stadt. Tabelle I-XXI

Offenes Antwortschreiben an das Stadt-Amt zu Riga

1885

The structure of charoite, (K,Sr,Ba,Mn)(15-16)(Ca,Na)(32)[(Si-70(O,OH)(180))](OH,F)(4.0)center dot nH(2)O, solved by conventional and automated elect…

2010

AbstractCharoite, ideally (K,Sr,Ba,Mn)15–16(Ca,Na)32[(Si70(O,OH)180)](OH,F)4.0·nH2O, a rare mineral from the Murun massif in Yakutiya, Russia, was studied using high-resolution transmission electron microscopy, selected-area electron diffraction, X-ray spectroscopy, precession electron diffraction and the newly developed technique of automated electron-diffraction tomography. The structure of charoite (a= 31.96(6) Å,b= 19.64(4) Å,c= 7.09(1) Å, β = 90.0(1)°,V= 4450(24) Å3, space groupP21/m) was solvedab initioby direct methods from 2878 unique observed reflections and refined toR1/wR2= 0.17/0.21. The structure can be visualized as being composed of three different dreier silicate chains: a d…

Efficient Coding of Quadtree Nodes

2006

In this paper an alternative non-pointer quadtree node codification to manage geographical spatial data is presented. New codification is based on a variable sequence of z-ordered base four digits. Memory requirements of the new codification are lower than previous codifications, and in particular lower than FD codification, the most commonly used in linear quadtrees. Furthermore, z-ordering makes compatible new codification with most of the algorithms developed for FD.

Enhancement of premature stop codon readthrough in the CFTR gene by Ataluren (PTC124) derivatives.

2015

Abstract Premature stop codons are the result of nonsense mutations occurring within the coding sequence of a gene. These mutations lead to the synthesis of a truncated protein and are responsible for several genetic diseases. A potential pharmacological approach to treat these diseases is to promote the translational readthrough of premature stop codons by small molecules aiming to restore the full-length protein. The compound PTC124 (Ataluren) was reported to promote the readthrough of the premature UGA stop codon, although its activity was questioned. The potential interaction of PTC124 with mutated mRNA was recently suggested by molecular dynamics (MD) studies highlighting the importanc…

Identification of a new molecule with readthrough activity to rescue CFTR protein function

In Cystic fibrosis (CF) disease nonsense mutations in the CFTR gene cause absence of the CFTR protein expression and a more severe form of the disease. About 10% of patient affected by CF show a nonsense mutation. A potential treatment of this alteration is to promote translational readthrough of premature termination codons (PTCs) by translational readthrough inducing drugs such as Ataluren. In this context we aimed to compare the 1,2,4-oxadiazole core of Ataluren with a slightly different scaffold, the 1,3,4oxadiazole core. By a validated protocol consisting of computational screening, synthesis and biological tests we identified, a new small molecule with 1,3,4-oxadiazole core (2a/NV2445…

R&D subsidies & external collaborative breadth: Differential gains and the role of collaboration experience

2018

The file attached to this record is the author's final peer reviewed version. External collaboration breadth is important for firms to acquire the knowledge needed to innovate. In this paper, we combine cross-sectional and longitudinal data from the Spanish Panel of Technological Innovation Survey (PITEC) to examine the indirect impact of R&D subsidies on firm external collaboration breadth. We contribute to understanding of the indirect impacts of R&D subsidies by first providing strong evidence of an economically significant average positive impact of R&D subsidies on firm external collaboration breadth. Second, our results advance understanding of the differential impacts of R&D subsidie…