Search results for "ADT"
showing 10 items of 92 documents
Toward a Rationale for the PTC124 (Ataluren) Promoted Readthrough of Premature Stop Codons: A Computational Approach and GFP-Reporter Cell-Based Assay
2014
The presence in the mRNA of premature stop codons (PTCs) results in protein truncation responsible for several inherited (genetic) diseases. A well-known example of these diseases is cystic fibrosis (CF), where approximately 10% (worldwide) of patients have nonsense mutations in the CF transmembrane regulator (CFTR) gene. PTC124 (3-(5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl)-benzoic acid), also known as Ataluren, is a small molecule that has been suggested to allow PTC readthrough even though its target has yet to be identified. In the lack of a general consensus about its mechanism of action, we experimentally tested the ability of PTC124 to promote the readthrough of premature termination c…
Zur Geschichte der öffentlichen Anlagen und Gärten der Stadt Riga
1913
Inhibition of FTSJ1, a tryptophan tRNA-specific 2’-O-methyltransferase as possible mechanism to readthrough premature termination codons (UGAs) of th…
2022
Cystic Fibrosis (CF) is an autosomal recessive genetic disease caused by mutations in the CFTR gene, coding for the CFTR chloride channel. About 10 % of the mutations affecting the CFTR gene are "stop" mutations, which generate a Premature Termination Codon (PTC), thus resulting in the synthesis of a truncated CFTR protein. A way to bypass PTC relies on ribosome readthrough, that is the capacity of the ribosome to skip a PTC, thus generating a full-length protein. “TRIDs” are molecules exerting ribosome readthrough and for some of them the mechanism of action is still under debate. By in silico analysis as well as in vitro studies, we investigate a possible mechanism of action (MOA) by whic…
Etalement urbain et consommation d'espace. Etude comparée de Besançon, Belfort et Montbéliard
2007
Urban sprawl constitutes a specific case of urbanization that is currently common in French cities. Arising from significant development of suburbs, it inevitably leads to the increase of built-up surfaces in every periurban area. At the same time, we can assume that urban sprawl induces over-consumption of space. This assumption is tested on the three main towns of Franche-Comté, that are associated with very different geographical, demographic and industrial characteristics (these characteristics are briefly described). The study confirms, in general, the reality of over-consumption of space, dependant on urban sprawl ; it seems generally independent of the individual characteristics of e…
La voce dei sommersi. Destino della musica europea negli anni del nazismo
2002
Il saggio traccia un quadro della politica culturale nazista nell'ambito della musica, con particolare riferimento alla mostra Entartete Musik ("Musica degenerata", 1938) e ai compositori attivi nel ghetto di Theresienstadt. L'ultimo capitolo è dedicato ai percorsi biografici e artistici di Viktor Ullmann e alla genesi, alla drammaturgia e ai caratteri musicali dell'opera in un atto "Der Kaiser von Atlantis" (L'Imperatore di Atlantide, 1943-44).
Eugen Alt † 17./29. April 1891: Erinnerungsblätter für seine Freunde
1891
Gotiskajā šriftā
Post-fotografia etnografica
2021
È evidente come la nostra società tecnologica sia legata senza alcun dubbio alla diffusione delle immagini. Autori come Gottfried Boehm, John Mitchell, Hans Belting hanno indagato la natura dell'immagine ponendo le basi, negli anni Novanta, per l'idea di un pictorial turn, di una cultura totalmente dominata dalle immagini che è diventata adesso una possibilità tecnica reale su scala globale. Un nuovo statuto dell'immagine che si usa raccogliere sotto l'etichetta di iconic turner inserito nel più vasto campo visual culture studies. L'uso del termine cultura accanto a quello di visuale è indicativo dell'ampiezza del campo d'indagine che visual culture studies si prefiggono di ricercare: essi …
Die alte Domschule und das daraus hervorgegangene Stadt-Gymnasium zu Riga: zur Erinnerung an die erste Begründung der Domschule vor 700 Jahren und an…
1910
Inhalt: 1. Teil. 1211-1804 in zweiter, bedeutend erweiterter Auflage ; 2. Teil. 1804-1896.
Rosyjski korpus posiłkowy (auksyliarny) na służbie Augusta II w Rzeczypospolitej i Saksonii. Nowe spojrzenie na sasko-polsko-rosyjską współpracę poli…
2019
Polityczno-militarna współpraca sasko-polsko-rosyjska od początku wielkiej wojny północnej (1700–1721) nie układała się po myśli Augusta II, który ponosił klęski w starciach z wojskami Karola XII i po przegranej Piotra I pod Narwą w 1700 roku wziął na siebie główny ciężar wojny. Próbą wspomożenia armii saskiej Augusta II przez cara, który obawiał się zawarcia przez władcę sasko-polskiego separatystycznego pokoju z królem szwedzkim, i chciał także zaangażowania w konflikt Rzeczypospolitej, było zorganizowanie rosyjskiego korpusu posiłkowego (auksyliarnego), który z perspektywy czasu okazał się zabiegiem politycznym, a w mniejszym stopniu wojskowym. W zaprezentowanym artykule recenzyjnym prob…
Bericht des permanenten Sanitäts-Comité der Stadt Riga über seine Wirksamkeit im Jahre 1878
1879
Inhalt: Einleitung ; I. Die Maßnahmen gegen drohende Epidemien ; II. Die Verunreinigungen der Straßen, Höfe, Plätze etc. ; III. Die fließenden und stagnirenden Gewässer ; IV. Die Latrinen und deren Vereinigung ; V. Die Fabriken und gewerblichen Anlagen ; VI. Das Leichen- und Beerdigungswesen ; VII. Die Bibliothek ; BEILAGE : 1. Bericht über den Stadtkanal / Dr. E. Bochmann, F. Weber, H. Malcher ; 3. Untersuchungsresultate der dem Stadtkanal entnommenen Schlammproblem ; 2. Bericht über die W. Franz'sche Knochenküche / Dr. J. Stavenhagen, Berichterstatter, Dr. Gehewe, F. Weber.