Search results for "ADULT"

Angiopoietin-2 plasma dosage predicts time to first treatment and overall survival in chronic lymphocytic leukemia.

2010

Abstract The clinical relevance of angiopoietin-2 (Ang2) in chronic lymphocytic leukemia (CLL) was previously suggested by the association between high Ang2, and shorter progression-free survival reported in small series of patients. Here, we evaluated Ang2 glycoprotein levels in plasma samples collected from a multicentric cohort of CLL patients (n = 316) using an enzyme-linked immunosorbent assay method, and we investigated its prognostic role in relation to time to first treatment (TTFT) and overall survival. Based on a cutoff equal to 2459 pg/mL, we divided our cohort in 2 subsets (high and low Ang2) composing 100 (31.6%) and 216 (68.4%) patients, respectively. High Ang2 was predictive …

Hepatitis C virus co-infection and sexual risk behaviour are associated with a high homocysteine serum level in HIV-infected patients.

2012

BACKGROUND AND AIMS: A better understanding of the relationship of homocysteine with cardiovascular risk factors is needed. The objectives of this study were to assess the serum level of homocysteine in HIV-infected patients and to analyse the possible association of increased levels of the amino acid with cardiovascular risk factors, demographic and clinical characteristics of participants. METHODS: Cross-sectional study carried out as a supplementary task to the usual controls necessary in HIV-infected patients in the outpatient clinic of the Hospital General of Castellon, Spain. For two consecutive visits the demographic, clinical and HIV-related characteristics and blood analyses result…

Modeling cost-effectiveness and health gains of a “universal” versus “prioritized” hepatitis C virus treatment policy in a real-life cohort

2017

We evaluated the cost-effectiveness of two alternative direct-acting antiviral (DAA) treatment policies in a real-life cohort of hepatitis C virus–infected patients: policy 1, “universal,” treat all patients, regardless of fibrosis stage; policy 2, treat only “prioritized” patients, delay treatment of the remaining patients until reaching stage F3. A liver disease progression Markov model, which used a lifetime horizon and health care system perspective, was applied to the PITER cohort (representative of Italian hepatitis C virus–infected patients in care). Specifically, 8,125 patients naive to DAA treatment, without clinical, sociodemographic, or insurance restrictions, were us…

Olfactory and cortical projections to bulbar and hippocampal adult-born neurons

2015

New neurons are continually generated in the subependymal layer of the lateral ventricles and the subgranular zone of dentate gyrus during adulthood. In the subventricular zone, neuroblasts migrate a long distance to the olfactory bulb where they differentiate into granule or periglomerular interneurons. In the hippocampus, neuroblasts migrate a short distance from the subgranular zone to the granule cell layer of the dentate gyrus to become granule neurons. In addition to the short-distance inputs, bulbar interneurons receive long-distance centrifugal afferents from olfactory-recipient structures. Similarly, dentate granule cells receive differential inputs from the medial and lateral ento…

Efectos del envejecimiento y el estrés oxidativo sobre la neurogénesis adulta en un modelo murino de senescencia acelerada

2015

El estudio exhaustivo de los mecanismos moleculares subyacentes a la disminución de la función de las células madre neurales (NSC) durante el envejecimiento, será fundamental en su futura aplicación terapéutica. El incremento en los niveles de estrés oxidativo, propio del proceso de envejecimiento, se ha postulado como una de las causas de daño en la función celular durante la senectud. Por otra parte, la cepa murina de envejecimiento acelerado SAMP8 (senescence-accelerated mouse prone), en la cual se ha descrito niveles elevados de estrés oxidativo, se considera un modelo válido para la investigación biogerontológica en el sistema nervioso central. A pesar del interés que ha suscitado la c…

Compartint visions sobre l’educació: Un projecte intergeneracional amb sèniors de la Universitat dels Majors y estudiants de Magisteri

2021

Memoria y patrimonio vivo es un proyecto de innovación educativa centrado en el diálogo intergeneracional de las experiencias de vida y de vida educativa entre estudiantes séniors (Universitat dels Majors) y juniors (estudiantes de Magisterio Infantil), que se ha desarrollado en la Universitat de València (Campus d’Ontinyent) con sesiones quincenales a lo largo de seis meses de trabajo. Durante el proyecto se estableció un diálogo intergeneracional sobre la educación a lo largo de la vida que permitió obtener diferentes visiones y superar estereotipos mutuos entre personas de distintas generaciones al aprender unas de otras a través de la interacción directa. El hecho de utilizar metodologí…

Tutkimus lastensuojelun tukihenkilötoiminnan muutoksista : relationaalinen näkökulma

2015

Aikuisten turvapaikanhakija- ja pakolaisasiakkaiden terapeuttisissa keskusteluissa kuvaamat hyödylliset muutokset

2018

Tutkimuksessa tarkastellaan sitä, kuinka kuusi aikuista turvapaikanhakija- ja pakolaisasiakasta kuvaavat kokemiaan hyödyllisiä muutoksia luonnollisissa terapeuttisissa keskusteluissa. Asiakkaiden keskustelukäynnit kriisikeskuksen työntekijöiden luona videotallennettiin. Tutkimuksen kohteena olivat asiakkaiden esittämät ja tulkkien suomeksi välittämät ilmaukset. Tutkimusmenetelmänä käytettiin aineistolähtöistä laadullista sisällönanalyysia. Analyysissä syntyi neljä hyödyllisen muutoksen kategoriaa. Hyödyllisen muutoksen kategorioita ovat helpottuneempi olotila, uusien ongelmiin ja elämään liittyvien hallintakeinojen omaksuminen, itseymmärryksen ja voimaantumisen tunteen lisääntyminen ja rake…

Cross‐country data on skills and the quality of schooling: A selective survey

2022

Scores in standardized international student achievement tests and some recent adult literacy studies provide interesting data on the quality of educational outputs and on the skill level of the population that can be a useful complement to the data on the quantity of schooling which have been most commonly used in the growth literature. This paper describes the most recent available primary data on the subject, reviews different attempts to organize, standardize, and summarize them, and discusses the strengths and weaknesses of the existing indicators and their potential usefulness as explanatory variables in empirical analyses of the determinants of income and welfare levels and growth ra…

The Global Blood Pressure Screening Campaign of the International Society of Hypertension

2020

Elevated blood pressure remains the single biggest risk factor contributing to the global burden of disease and mortality. May Measurement Month is an annual global screening campaign aiming to improve awareness of blood pressure at the individual and population level. Adults (≥18 years) recruited through opportunistic sampling were screened at sites in 92 countries during May 2019. Ideally, 3 blood pressure readings were measured for each participant, and data on lifestyle factors and comorbidities were collected. Hypertension was defined as a systolic blood pressure ≥140 mm Hg, or a diastolic blood pressure ≥90 mm Hg (mean of the second and third readings) or taking antihypertensive medic…