Search results for "AGEING"

Immunological and immunogenetic markers of successful and unsuccessful ageing

2002

Development of Methods for the Evaluation of Olive Oil Oxidation

2012

In this work, the chemical changes produced in an EVOO sample, both in the presence and absence of its phenolic fraction during an accelerated ageing treatment have been studied. The changes produced in phenolic compound concentrations, jointly with the changes observed in free acidity, peroxide value, UV absorbance, fatty acid composition, OSI and T content, were monitored. In addition, transformation of phenolic compounds during the accelerated ageing treatment in EVOO samples with phenolic fraction was also studied.

Happiness in advanced adulthood and elderly: The role of positive emotions, flourishing and mindfulness as wellbeing factors for successful ageing

2019

This study critically analyses the role of Happiness among the Portuguese elderly. The term is understood as a grouping of variables including Subjective Well-being, defined by satisfaction with life, positive and negative affects, flourishing, optimism and pessimism, positive and negative emotions, meaning of life, religiosity, Spirituality, and mindfulness. The qualities of Happiness are explored as they contribute to successful ageing and higher levels of Happiness in the elderly. We conducted a correlational study of 329 participants, aged 55 to 98 years. We used several questionnaires to gather data as a socio-demographic questionnaire, Satisfaction with Life Scale (SWLS), Positive and…

Degradation mechanisms under hydro-thermo-mechanical loads of natural fibers-reinforced biocomposites : application to the development of lightweight…

2018

With the current environmental concerns, research turns to alternative solutions to synthetic fibres. Vegetal fibers appears as good candidates, with good mechanical properties. However, their low durability is a major issue, especially when the composites are exposed to hydro(hygro)thermal loadings.The purpore of this thesis is to analyse and understand the degradation mechanisms when hydro-thermo-mechanical loadings are applied, in order to implement a predictive modelisation of the composite durability.The manufacturing process wasstudied and optimised to produce reproducible and strong composites. Two materials were produced. Their only difference is their volumetric fiber contents (37.…

Possible Association of Telomere Length with Sleep Duration. A Preliminary Pilot study in a Sicilian Cohort with Centenarians

2021

Telomere length (TL) is considered a biomarker of ageing although this topic is still debated. Also, sleep pattern changes are physiological part of the normal ageing process. In fact, it is widely recognized that sleep duration declines with age, leading to dysregulation of circadian rhythms. The aim of our study was to analyse the possible association of sleep duration with TL in a sample of 135 subjects with ages ranging from 20 to 111 years, recruited from Palermo and neighbouring municipalities in Sicily (Italy). Preliminary data suggest that relative TL (RTL) decreases with age in both men and women. However, at older ages, the difference between men and women tends to narrow. Nonagen…

Ethics of ageing

2021

In the coming decades the world will face an unprecedented change in the composition of its population that will reshape and challenge social and political systems. Unique in human history, this change, unlike most of the changes that societies will experience during the next 50 years, is largely predictable. Population aging, with advances in medical technology, ensures that the allocation problem will continue to affect societies as far as one can see into the future. Currently this issue has mostly been formulated in terms of challenges created by increasing costs, and the focus has been squarely on life-prolonging treatments. In doing so, we’re missing many other important issues which …

The effect of ageing and physical activity level on muscle fatigue during isometric contraction of knee extensor muscles

2013

Nahar, Nazmun 2013. Effect of ageing and physical activity level on muscle fatigue during isometric contraction of knee extensor muscles. Master’s theses in Biomechanics. Department of Biology of Physical Activity, University of Jyväskylä, Finland. Muscle fatigue is defined as the loss of force or power producing capacity in response to contractile activity and is a fundamental characteristic of skeletal muscle. The aim of this study was to identify whether time to failure remains same or increases in elderly people compared with young people. Another aim was to identify time to failure is same or less in active old people compared with inactive old people. One hundred and ten subjects were…

Centenarians as a model to discover genetic and epigenetic signatures of healthy ageing.

2018

Abstract Centenarians are a model of successful ageing. The data favours the theory that, in order to live to 100, it is mandatory to inherit the right genetic variants from parents or acquire epigenetic variants through the environment. Therefore, the study of epigenetic signatures of healthy ageing is becoming an important aspect to identify the role of chromatin modification in ageing and understand how manage this fine-tuning system. So, according to the concept of developmental plasticity, establishment of a longevity phenotype requires a combination of stochastic and non-stochastic events that modulate the genetic substrate and leads to a different outcome. It can be concluded that ce…

Reviewer acknowledgment

2013

Contributing reviewers Immunity & Ageing would like to thank the following for their assistance with peer review of manuscripts for the journal in 2012.

B Cells Compartment in Centenarian Offspring and Old People

2010

Immunosenescence is considered a major contributory factor to the increased frequency of morbidity and mortality among elderly. On the other hand centenarians are considered the best example of successful ageing. To gain insight into mechanisms of immunosenescence and its clinical relevance, a possible model is represented by centenarians and/or their offspring. Nowadays centenarians are not more a curiosity, but in Europe are 1/8000 inhabitants and it has been demonstrated that the centenarian offspring, who are typically in their 70s and 80s, have a survival advantage when compared with age-matched controls whose parents died at an average life expectancy. Then again, studies on immunosen…