Search results for "AIH"
showing 10 items of 785 documents
Cell-List based Molecular Dynamics on Many-Core Processors: A Case Study on Sunway TaihuLight Supercomputer
2020
Molecular dynamics (MD) simulations are playing an increasingly important role in several research areas. The most frequently used potentials in MD simulations are pair-wise potentials. Due to the memory wall, computing pair-wise potentials on many-core processors are usually memory bounded. In this paper, we take the SW26010 processor as an exemplary platform to explore the possibility to break the memory bottleneck by improving data reusage via cell-list-based methods. We use cell-lists instead of neighbor-lists in the potential computation, and apply a number of novel optimization methods. Theses methods include: an adaptive replica arrangement strategy, a parameter profile data structur…
Lifestyle counseling to reduce body weight and cardiometabolic risk factors among truck and bus drivers – a randomized controlled trial
2015
Objectives We conducted a randomized trial among overweight long-distance drivers to study the effects of structured lifestyle counseling on body weight and cardiometabolic risk factors. Methods Men with waist circumference > 100 cm were randomized into a lifestyle counseling (LIFE, N=55) and a reference (REF, N=58) group. The LIFE group participated in monthly counseling on nutrition, physical activity, and sleep for 12 months aiming at 10% weight loss. After 12 months, the REF group participated in 3-month counseling. Assessments took place at 0, 12, and 24 months. Between-group differences in changes were analyzed by generalized linear modeling. Metabolic risk (Z score) was calculated fr…
CrossFit Suomen jälkimodernissa liikuntakulttuurissa : CrossFitin rantautuminen, organisoituminen ja laji liikuntamuotona
2016
Kauppinen, A. 2016. CrossFit Suomen jälkimodernissa liikuntakulttuurissa. CrossFitin rantautuminen, organisoituminen ja laji liikuntamuotona. Liikuntakasvatuksen laitos, Jyväskylän yliopisto. Liikunnan yhteiskuntatieteiden pro gradu -tutkielma, s.85, 2 liitettä. Suomalainen liikuntakulttuuri elää jatkuvassa muutoksen tilassa. Uusi sukupolvi muokkaa perinteisiä liikuntalajeja uudelleen vastaamaan paremmin nykyisiä tarpeitaan. Samalla virtuaalimaailman kehitys tuo kaukaisemmatkin liikuntavaikutteet lähelle. Liikunnalle asetetaan yhä kokonaisvaltaisempia merkityksiä ihmisten arjessa ja yhteiskunnassa. Uusia liikuntalajeja tutkimalla saadaan yhteiskunnallisesti arvokasta tietoa liikunnan muuttu…
The relationship between health-related quality of life and melancholic depressive symptoms is modified by brain insulin receptor gene network
2021
AbstractTo investigate whether expression-based polygenic risk scores for the insulin receptor gene network (ePRS-IRs) modifiy the association between type of depressive symptoms and health-related quality of life (HRQoL). This cross-sectional study includes 1558 individuals from the Helsinki Birth Cohort Study. Between 2001 and 2004, the Short Form-36 questionnaire was employed to assess mental and physical components of HRQoL and Beck Depression Inventory (BDI) to assess depressive symptoms. Depressive symptoms were categorized into minimal (BDI < 10), non-melancholic and melancholic types of depression. The ePRS-IRs were calculated for the hippocampal (hePRS-IR) and the mesocorticolim…
Alaraajojen luun mineraalipitoisuuden ja polven nivelruston väliset yhteydet postmenopausaalisilla naisilla
2011
Tämän poikkileikkaustutkimuksen tarkoituksena oli selvittää luuston (reisiluun kaula, lanneranka L2-L4) mineraalitiheysarvojen ja polven nivelruston (reisiluu, sääriluu) eheyttä kuvaavien dGEMRIC-arvojen välistä yhteyttä postmenopausaalisilla naisilla. Tutkimukseen rekrytoitiin 82 naista (keskimääräiseltä iältään 57,7 vuotta, SD 4,2) lehti-ilmoituksen perusteella. Sisäänottokriteerinä oli rtg:llä arvioidun Kellgren-Lawrence-luokituksen (K/L) mukaan ensimmäisen (K/L1) tai toisen (K/L2) asteen lievä polven nivelrikko. Reisiluun kaulan ja lannerangan (L2–L4) BMC-arvot mitattiin DXA-laitteistolla. Tutkimushenkilöillä ei ollut osteoporoosia, jonka kynnysarvona käytettiin T-arvoa >2,5. Tibian ja …
Nopean painonpudotuksen vaikutukset kehon koostumukseen sekä neste- ja hormonitasapainoon kansallisen huipputason painijoilla
2007
Sarkkinen, Pasi 2007. Nopean painonpudotuksen vaikutukset kehon koostumukseen sekä neste- ja hormonitasapainoon kansallisen huipputason painijoilla. Liikuntabiologian laitos, Jyväskylän yliopisto. Pro Gradu –tutkielma. Nopean ja suuren painonpudotuksen vaikutuksia urheilijan elimistöön on tutkittu verrattain vähän ja mahdollisia terveydellisiä riskejä ei ole juurikaan tiedostettu. Nopea painonpudotus on hyvin yleisesti käytetty menetelmä painoluokkalajeissa, kun normaalipaino ylittää kilpailusarjan. Painijoiden painon pudotus ala- ja keskisarjoissa on useimmiten 5-8 kg eli 8-12 % kehonpainosta. 18 tervettä suomalaista painijaa osallistui kreikkalais-roomalaisen tyylin SM-kilpailuihin (2004)…
Arbuscular mycorrhizal fungi influence host infection during epidemics in a wild plant pathosystem
2022
SummaryWhile pathogenic and mutualistic microbes are ubiquitous across ecosystems and often co-occur within hosts, how they interact to determine patterns of disease in genetically diverse wild populations is unknown.To test whether microbial mutualists provide protection against pathogens, and whether this varies among host genotypes, we conducted a field experiment in three naturally-occurring epidemics of a fungal pathogen, Podosphaera plantaginis, infecting a host plant, Plantago lanceolata, in the Åland Islands, Finland. In each population, we collected epidemiological data on experimental plants from six allopatric populations that had been inoculated with a mixture of mutualistic arb…
A spontaneous mitonuclear epistasis converging on Rieske Fe-S protein exacerbates complex III deficiency in mice
2020
We previously observed an unexpected fivefold (35 vs. 200 days) difference in the survival of respiratory chain complex III (CIII) deficient Bcs1lp.S78G mice between two congenic backgrounds. Here, we identify a spontaneous homoplasmic mtDNA variant (m.G14904A, mt-Cybp.D254N), affecting the CIII subunit cytochrome b (MT-CYB), in the background with short survival. We utilize maternal inheritance of mtDNA to confirm this as the causative variant and show that it further decreases the low CIII activity in Bcs1lp.S78G tissues to below survival threshold by 35 days of age. Molecular dynamics simulations predict D254N to restrict the flexibility of MT-CYB ef loop, potentially affecting RISP dyna…
Tutkimusmatka pienyrittäjän työvalmiuksien ytimeen : kirjallisuuteen ja DACUM-analyysiin perustuva kartoitus
2007
This study examines the occupational competence and attitudes that small business entrepreneurs consider essential to their work. Small business entrepreneurs were given an opportunity to express their views in small focus groups of peer entrepreneurs. Consensus opinions formulated by the groups were then meticulously documented. The results expose the very core or soul of entrepreneurial competence and attitudes by determining what small business entrepreneurs feel they must be able to do. Acknowledgement and acceptance of tacit knowledge as part of one's competence and attitudes would introduce a systematic approach to the recording of such knowledge and enable its transfer to co-workers …
Survey of methods to visualize alternatives in multiple criteria decision making problems
2012
When solving decision problems where multiple conflicting criteria are to be considered simultaneously, decision makers must compare several different alternatives and select the most preferred one. The task of comparing multidimensional vectors is very demanding for the decision maker without any support. Different graphical visualization tools can be used to support and help the decision maker in understanding similarities and differences between the alternatives and graphical illustration is a very important part of decision support systems that are used in solving multiple criteria decision making problems. The visualization task is by no means trivial because, on the one hand, the grap…