Search results for "ALK"
showing 10 items of 4314 documents
Marquage de molécules biologiques par des complexes de radiométaux à base de polyamines macrocycliques
2012
This work conducted at the “Institut de Chimie Moléculaire de l’Université de Bourgogne” carries at first on the synthesis of bifunctional chelating agents suitable for the chelation of trivalent radiometals, including indium-111. The greater part of this work was then dedicated to the grafting of a DOTA derivative bifunctional chelating agent on different antibodies or fragments of monoclonal antibodies: trastuzumab (anti-HER2 treatment of breast cancer), cetuximab (anti EGFR, treatment of many cancers, including colorectal cancer) and abciximab (antiplatelet). Particular attention was paid to the characterization of various immunoconjugates. The critical step of this thesis consisted in t…
Widespread diminishing anthropogenic effects on calcium in freshwaters
2019
Calcium (Ca) is an essential element for almost all living organisms. Here, we examined global variation and controls of freshwater Ca concentrations, using 440 599 water samples from 43 184 inland water sites in 57 countries. We found that the global median Ca concentration was 4.0 mg L−1 with 20.7% of the water samples showing Ca concentrations ≤ 1.5 mg L−1 , a threshold considered critical for the survival of many Ca-demanding organisms. Spatially, freshwater Ca concentrations were strongly and proportionally linked to carbonate alkalinity, with the highest Ca and carbonate alkalinity in waters with a pH around 8.0 and decreasing in concentrations towards lower pH. However, on a temporal…
Twin Peaks: Fire Walk With Me (1992) and David Lynch's Aesthetics of Frustration
2010
This article focuses on Twin Peaks: Fire Walk With Me (David Lynch,1992), the prequel to the TV series produced by Mark Frost and David Lynch (1990-1991), which represents a turning point in Lynch's filmography. The author argues that the film's aesthetics frustrate viewer expectations, and especially the fan of the TV series, by addressing the issue of the film's relation to the TV series. Special attention is payed to the aesthetics of time passing and to the accumulation of unusual signs in the first part of the film, with reference to Deleuze and Michel Guiomar, and the way they lead the spectator, fan or neophyte, to expect something Fantastic to happen. The article then addresses the …
Measurements of diachronic stability of agrarian exploitation
2007
International audience; Off-site material has two main interesting properties which are that it is spatially continuous and diachronic. Such data can be used to estimate how ancient societies invested in a space in terms of intensity, durability and stability, over the long term. This micro-analysis is based on a precise record of off-site material based on collection units which never exceed five hectares. Each off-site sherd was dated and attributed to one of seven chronological phases. Three new indicators are proposed to measure the level of investment of ancient societies. The computing and mapping of these indicators was done using GIS software. The data used in this paper come mainly…
Breakthrough in the α-Perchlorination of Acyl Chlorides
2012
The preparation of -perchloroacyl chlorides, from reaction of the corresponding unfunctionalized acyl halides with chlorine, was efficiently achieved under base-catalysis, using a tetraalkylammonium chloride as catalyst. The process is solvent-free and the procedure is easy, inexpensive, and suitable for scale-up.
Acid−Base Properties of Synthetic and Natural Polyelectrolytes: Experimental Results and Models for the Dependence on Different Aqueous Media
2008
Protonation constants of several natural and synthetic humates and fulvates were determined by ISE-H+ potentiometry in different ionic media (alkali metal halides and tetraethylammonium iodide) at different ionic strengths and T ) 298.15 K. Experimental data obtained in previous studies of different synthetic (polyacrylates, polymethacrylates, polyacrylate-co-maleate) and naturally occurring (alginate, humic substances) polycarboxylates were also taken into account in the general analysis of acid-base properties of polyelectrolytes. Protonation constants were expressed as a function of the dissociation degree (R) using three models, namely, a simple linear model, the Ho¨gfeldt three-paramet…
El stalking, un nuevo delito
2014
El último proyecto de reforma del Código Penal español en el año 2013 incorpora el llamado delito de stalking, o acoso insistente y reiterado a otra persona, con previsión de distintas conductas y pudiendo ser sujeto activo y pasivo tanto el hombre, la mujer o personas del mismo sexo.
Entisten suomalaisten huippu-urheilijoiden alkoholinkäyttö ja alkoholisairauksien riski
2016
Kontro, T. 2016. Entisten suomalaisten huippu-urheilijoiden alkoholinkäyttö ja alkoholisairauksien riski. Terveystieteiden laitos, Jyväskylän yliopisto, liikuntalääketieteen pro gradu -tutkielma, 69 s., 7 liitettä. Tutkimuksen tausta ja tarkoitus: Haitallinen alkoholinkäyttö on globaali ongelma. Myös entisten huippu-urheilijoiden alkoholinkäytöstä on keskusteltu mediassa paljon, mutta tieteellistä näyttöä aiheesta ei juurikaan ole olemassa. Tämän tutkimuksen tarkoituksena oli tutkia aiemman kilpaurheilu-uran ja alkoholisairauksien välistä yhteyttä sekä alkoholinkäyttöä eri urheilulajiryhmissä ja verrokeilla. Lisäksi haluttiin selvittää eri taustamuuttujien, kuten kilpa- ja kuntourheiluaktiv…
Relationship among Body Composition, Adipocytokines, and Irisin on Exercise Capacity and Quality of Life in COPD: A Pilot Study
2022
Adipose tissue is an endocrine organ that interferes with the severity of chronic obstructive pulmonary disease (COPD). Although inflammatory markers, body composition, and nutritional status have a significant impact on pulmonary function, the real contribution of adipocytokines and myokines in COPD is still controversial. We aimed to evaluate the role played by the body composition, leptin, adiponectin, haptoglobin, and irisin on the functional exercise capacity, respiratory function, and quality of life (QoL) in COPD. In 25 COPD (20% GOLD-1; 60% GOLD-2; 20% GOLD-3) patients and 26 matched control subjects, we find that leptin, total adiponectin and haptoglobin are significantly increased…
Editorial: Myokines, Adipokines, Cytokines in Muscle Pathophysiology, Volume II.
2022
No Abstract available