Search results for "ALK"

showing 10 items of 4314 documents

Insertion of One, Two, and Three Molecules of Alkyne into the Pd−C Bond of Ortho-palladated Primary and Secondary Arylalkylamines

2009

The ortho-metalated complex [Pd2{κ2(C,N)-C6H4CH2CH2NHMe-2}2(μ-Br)2] (1) can be prepared by refluxing a 1:1 mixture of Pd(OAc)2 and N-methylphenethylamine in acetonitrile, followed by addition of an excess of NaBr. Complex 1 reacts with PPh3 to give the mononuclear derivative [Pd{κ2(C,N)-C6H4CH2CH2NHMe-2}Br(PPh3)] (2). The cationic complex [Pd{κ2(C,N)-C6H4CH2CH2NHMe-2}(py)2]ClO4 (3) can be obtained by reacting 1 with AgClO4 and pyridine. The previously reported complex [Pd2{κ2(C,N)-C6H4CH2NHCH2Ph-2}2(μ-Br)2] (A) reacts with PhC≡CCO2R (R = Me, Et) to give the monoinserted derivatives [Pd2{κ2(C,N)-C(Ph)═C(CO2R)C6H4CH2NHCH2Ph-2}2(μ-Br)2] (R = Me (4a), Et (4b)). These dimers react with neutral l…

chemistry.chemical_classificationStereochemistryOrganic ChemistryCationic polymerizationAlkyneMedicinal chemistryInorganic Chemistrychemistry.chemical_compoundMonomerchemistryMolar ratioPyridineMoleculePhysical and Theoretical ChemistryAcetonitrileOrganometallics
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Vergleichende dimerisierung der enantiomere von Oct-1-in-3-ol mit chiralen rhodium-phosphan-komplexen

1996

Abstract Three optically active phosphanes ([(S)-2-methylbutyl]3−nP[phenyl]n(n = 0, 1, 2), were tested as ligands in rhodium(I) complexes to form catalysts for the enantioselective dimerisation of (R)- and (S)-oct-1-yn-3-ol. The catalytic reaction provides enantioselectivity for this type of CC bond formation. For reactions at 45–75°C and depending on the P-ligand used the rates vary for both enantiomers from 6:1 to 50:1 in favour of the (S)-octynol.

chemistry.chemical_classificationStereochemistryOrganic ChemistryEnantioselective synthesisAlkynechemistry.chemical_elementBond formationBiochemistryRhodiumCatalysisInorganic Chemistrychemistry.chemical_compoundchemistryMaterials ChemistryPhysical and Theoretical ChemistryEnantiomerChirality (chemistry)PhosphineJournal of Organometallic Chemistry
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Regioselective synthesis of calixcrowns derived from p-tert-butylcalix[5]arene

1993

Abstract Alkylation of p-tert-butylcalix[5]arene with oligoethylene glycol-ditosylates in the presence of CsF affords the 1,3-bridged calix[5]crowns 1a–c in 51 to 72% yield. In the case of hexaethylene glycol the isomeric 1,2-bridged calix[5]crown-7 2c was obtained additionally. The calixcrowns were further modified by alkylation of the remaining hydroxyl groups.

chemistry.chemical_classificationStereochemistryOrganic ChemistryRegioselectivityAlkylationBiochemistryMedicinal chemistrychemistry.chemical_compoundPolycyclic compoundchemistryYield (chemistry)Drug DiscoveryCalixareneHexaethylene glycolCyclophaneTetrahedron
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Stereoselective reactions of a thioester butanediacetal with various electrophiles

2014

Abstract The reactions of the lithium enolate of S -ethyl (2 R ,5 R ,6 R )-5,6-dimethoxy-5,6-dimethyl-[1,4]-dioxane-2-carbothioate were investigated in the presence or absence of hexamethylphosphoramide (HMPA). Fluorination gave a single isomer with a much better yield than for the corresponding methyl ester. Alkylation with alkyl halides strongly depended upon their structure. Without HMPA, only methyl iodide reacted with moderate yield and gave a single isomer. In the presence of HMPA, all of the alkyl halides reacted almost quantitatively (81–98% yield) with moderate stereoselectivity and preferentially gave products with the alkyl chain attached at the equatorial position. The silyl eno…

chemistry.chemical_classificationStereochemistryOrganic ChemistrySilyl enol etherAlkylationThioesterMedicinal chemistryCatalysisInorganic Chemistrychemistry.chemical_compoundchemistryHexamethylphosphoramideElectrophileStereoselectivityPhysical and Theoretical ChemistryAlkylMethyl iodideTetrahedron: Asymmetry
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Alcoholysis of Aluminum Alkyls Supported by Bulky Phenoxide Ligands: Synthesis, Characterization, and ε-Caprolactone Polymerization Activity of Two D…

2000

Reaction of trialkylaluminum Al2R6 (R = Me, Et) with 2,2′-methylenebis(6-tert-butyl-4-methylphenol) (mbmpH2) gives the dimeric mono(alkyl) complex [Al(mbmp)R]2 with bridging oxygen atoms. Reaction of [Al(mbmp)R]2 with one equiv. of 2-propanol results in the formation of the dimeric isopropoxide [Al(mbmp)(μ-OiPr)]2. Single-crystal X-ray analysis shows a C2h-symmetric structure with a planar Al2O2 core. Monomeric methylbis(2,6-di-tert-butyl-4-methylphenolato)aluminum, AlMe(OC6H2-2,6-tBu2-4-Me)2 (MAD), was found to react with one equiv. of 2-propanol to give a dimeric isopropoxide [AlMe(OC6H2-2,6-tBu2-4-Me)(μ-OiPr)]2 in which the bulky phenolate, instead of the methyl group, has been displaced…

chemistry.chemical_classificationStereochemistryPolymerMedicinal chemistryTolueneInorganic Chemistrychemistry.chemical_compoundMonomerchemistryPolymerizationMoleculeAlkylLactoneMethyl groupEuropean Journal of Inorganic Chemistry
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Monolayers of Bolaform Amphiphiles: Influence of Alkyl Chain Length and Counterions

1994

We have prepared self-assembled monolayers of novel cationic bolaform amphiphiles on negatively charged substrates. Most of these amphiphiles form smooth, defect-free monolayers which can be used to reverse the substrate surface charge and thus allow subsequent adsorption of anionic molecules and construction of multilayers. Atomic force microscopy, surface force measurement, and surface plasmon spectroscopy were combined to probe the molecular orientation and ordering, mechanical properties, and surface electrical properties of the monolayers. In addition, the amphiphile aggregation behavior at an air-water interface was studied by surface tension measurement, and lyotropic phase behavior …

chemistry.chemical_classificationStereochemistrySurface forceSurfaces and InterfacesCondensed Matter PhysicsSurface tensionchemistryChemical physicsAmphiphileLyotropicMonolayerElectrochemistryMoleculeGeneral Materials ScienceSurface chargeSpectroscopyAlkylLangmuir
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Silica-Immobilized NHC-Gold(I) Complexes: Versatile Catalysts for the Functionalization of Alkynes under Batch and Continuous Flow Conditions

2017

Immobilized sterically demanding NHC-Au(I) complexes silica-[(IPrR)Au]Cl and silica-[(IAdPrR)Au]Cl are synthesized and characterized. These complexes are suitable catalysts in typical homogeneous Au(I)-catalyzed alkyne reactions such as hydration, hydroamination, hydroarylation, or cycloisomerization. The results obtained with the immobilized catalysts in reactions in batch are comparable to those obtained with their homogeneous counterparts with the advantage of easily recovered and recycled in successive reactions. Their catalytic activity decreases when reused in batch reactions, probably because of crushing that is associated with magnetic stirring. In contrast, these immobilized cataly…

chemistry.chemical_classificationSteric effects010405 organic chemistryContinuous flowInorganic chemistryAlkyneGeneral ChemistryFlow chemistry010402 general chemistry01 natural sciencesCombinatorial chemistryCatalysis0104 chemical sciencesCatalysisCycloisomerizationchemistrySurface modificationHydroaminationACS Catalysis
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Synthesis, crystal structures and magnetic properties of M(II)Cu(II) chains (M = Mn and Co) with sterically hindered alkyl-substituted phenyloxamate …

2011

A series of neutral oxamato-bridged heterobimetallic chains of general formula [MCu(L(x)2 (S)2] · p S · q H2O [p = 0-1, q = 0-2.5; L1 = N-2,6-dimethylphenyloxamate, S = DMF with M = Mn (1a) and Co (1b); L2 = N-2,6-diethylphenyloxamate, S = DMF with M = Mn (2a) and Co (2b) or S = DMSO with M = Mn (2c) and Co (2 d); L3 = N-2,6-diisopropylphenyloxamate, S = DMF with M = Mn (3a) and Co (3b) or S = DMSO with M = Mn (3c) and Co (3d)] were prepared by treating the corresponding anionic oxamatocopper(II) complexes [Cu(L(x))(2)]2- (x = 1-3) with M(2+) cations (M = Mn and Co) in DMF or DMSO as the solvent. The single-crystal X-ray structures of 2a and 3a reveal the occurrence of well-isolated, zigzag…

chemistry.chemical_classificationSteric effectsArrhenius equationStereochemistryOrganic Chemistrychemistry.chemical_elementGeneral ChemistryActivation energyManganeseCrystal structureCatalysisCrystallographysymbols.namesakechemistryOctahedronFerrimagnetismsymbolsAlkylChemistry (Weinheim an der Bergstrasse, Germany)
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Synthesis and Reactivity of New Chelate-N-Heterocyclic Biscarbene Complexes of Ruthenium

2004

The carbene-ligand precursors methylenebis(N-alkylimidazolium) iodide (alkyl = methyl, neo-pentyl) and ethylenebis(N-methylimidazolium) chloride have been used in the preparation of several new Ru(II)-p-cymene complexes where the ligand behaves as mono- and bidentate. The molecular structures of the two biscarbene-complexes are reported. From the data reported, we can conclude that steric reasons (mainly the bisimidazolium linkers, methylene/ethylene) are the main factors determining both reactivity and synthetic difficulties of the products reported.

chemistry.chemical_classificationSteric effectsDenticityLigandStereochemistryIodidechemistry.chemical_elementMedicinal chemistryRutheniumInorganic Chemistrychemistry.chemical_compoundchemistryReactivity (chemistry)Physical and Theoretical ChemistryMethyleneAlkylInorganic Chemistry
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Thermodynamics of binary mixtures: Volumes, heat capacities, and dilution enthalpies for then-pentanol+2-methyl-2-butanol system

1983

The densities, heat capacities, and dilution enthalpies ofn-pentanol+2-methyl-2-butanol mixtures have been measured, in many cases as a function of temperature, over the complete mole fraction range. Excesses thermodynamic properties, apparent and partial molar heat capacities, volumes and expansibilities were derived. The concentration and temperature dependences of these functions are discussed in terms of the variations of the structure of the system caused by the participation of the two alcohol molecules (with quite different steric hindrance of the alkyl chain around the-OH group) in the dynamic intermolecular association process through hydrogen bonding.

chemistry.chemical_classificationSteric effectsHydrogen bondIntermolecular forceBiophysicsThermodynamicsBiochemistryHeat capacityDilutionchemistry.chemical_compoundchemistryPhysical chemistryBinary systemPhysical and Theoretical ChemistryMolecular Biology2-ButanolAlkylJournal of Solution Chemistry
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