Search results for "ALK"
showing 10 items of 4314 documents
Sulfonamide moiety as "molecular chimera" in the design of new drugs.
2021
Background: The -SO2NH- group is of great significance in modern pharmaceutical use since, in sulfa-drugs, it is possible to introduce easily chemical modifications, and even small changes may lead to an improved version of an already existing drug. Objective: This paper aims to describe updated information in the sulfonamide field with a particular focus on new mechanisms of action, especially if discovered by employing computational approaches. Methods: Research articles that focused on the use of the sulfonamide moiety for the design, synthesis, and in vitro/in vivo tests of various diseases were collected from various search engines like PubMed, Science Direct, Google Scholar, and Scop…
Associations of physical activity in detailed intensity ranges with body composition and physical function : a cross-sectional study among sedentary …
2020
Background Physical activity is crucial to maintain older adults’ health and functioning, but the health benefits of particular activity intensities remain unclear. The aim of this cross-sectional study was to peruse the distribution of physical activity, and to investigate the associations of particular physical activity intensities with body composition and physical function among older adults. Methods The sample comprised of 293 community-dwelling sedentary or at most moderately active older adults (42% men, mean age 74 ± 4 years). Physical activity was measured with a hip-worn tri-axial accelerometer over seven consecutive days, and investigated in detailed intensity range and in catego…
Physical qualities and body composition predictors of running performance in national level women’s official soccer matches
2023
The purpose of the study was to (1) determine match running performance, anthropometry and various physical qualities of national level women soccer players and (2) identify key physical qualities and anthropometric predictors of match running profile during a competitive season. Twenty-five national level Finnish soccer players participated in the study. Players performed countermovement jump, loaded squat jumps, 30-meter sprint, maximum isokinetic knee flexor and extensor contractions, an incremental treadmill test and underwent body composition assessment in the lab. Match running performance was analyzed from 115 match observations during competitive league matches over 11 weeks after t…
Paineensietoa kehittämällä voi edistää päätöksentekoa ja suoritusta
2021
Beeta-alaniinin nauttimisen vaikutukset veren pH- ja laktaattiarvoihin sekä fyysiseen suorituskykyyn
2008
Saltevo, Saana Sinikka. Liikuntafysiologian kandidaattitutkielma. Kesä 2008. Beeta- alaniinin nauttimisen vaikutukset veren pH- ja laktaattiarvoihin sekä fyysiseen suorituskykyyn. 41 s. Beeta-alaniini muodostaa lihaskudoksessa karnosiinia, joka on lihaksen tärkeimpiä puskureita. Korkeaintensiteettisessä suorituksessa lihaksen pH:n laskun minimointi saattaisi olla hyödyksi lihassupistuksen optimaalisen toiminnan kannalta. Tämän tutkimuksen tarkoituksena oli selvittää vaikuttaako beeta-alaniini veren happamuuteen, laktaattiin ja fyysiseen suorituskykyyn. Tutkimukseen osallistui viisitoista jyväskyläläistä miesjalkapalloilijaa (21.3 ± 2.8 v.). Koehenkilöt jaettiin kahteen ryhmään, joista toise…
"Pysäyttää ajatukset hetkeen, kun astuu luontoon ja retkeen" : luonnossa ulkoilun yhteydet työhyvinvointiin
2017
Tutkimuksemme tavoitteena oli tutkia, miten työntekijät kokevat luonnossa ulkoilun vaikuttavan heidän työhyvinvointiinsa. Selvitimme myös millaisia yhteyksiä luonnon koetuilla vaikutuksilla sekä luontovierailun kestolla oli työhyvinvointiin, jota tarkastelimme työn imun ja työuupumuksen käsitteiden avulla. Lisäksi tarkastelimme luonnon koettujen vaikutusten yhteyttä luontovierailun kestoon. Tutkimuksemme aineisto koostui kyselytutkimuksesta, johon vastasi 783 työntekijää 13 eri organisaatiosta kevään ja syksyn 2016 aikana. Luonnossa ulkoilun koettuja vaikutuksia työhyvinvointiin tutkittiin avoimella kysymyksellä, jonka vastaukset luokiteltiin. Pearsonin korrelaatiokertoimen avulla tarkastel…
Structural Motifs of Alkali Metal Superbases in Non‐coordinating Solvents
2020
Abstract Lochmann–Schlosser superbases (LSB) are a standard reagent in synthetic chemistry to achieve an exchange of a proton on an organic framework with an alkali metal cation, which in turn can be replaced by a wide range of electrophilic groups. In standard examples, the deprotonating reagent consists of an equimolar mixture of n‐butyllithium and potassium t‐butoxide. However, the nature of the reactive species could not be pinned down either for this composition or for similar mixtures with comparable high reactivity. Despite the poor solubility and the fierce reactivity, some insights into this mixture were achieved by some indirect results, comparison with chemically related systems,…
On the adsorption and reactivity of element 114, flerovium
2022
Flerovium (Fl, element 114) is the heaviest element chemically studied so far. To date, its interaction with gold was investigated in two gas-solid chromatography experiments, which reported two different types of interaction, however, each based on the level of a few registered atoms only. Whereas noble-gas-like properties were suggested from the first experiment, the second one pointed at a volatile-metal-like character. Here, we present further experimental data on adsorption studies of Fl on silicon oxide and gold surfaces, accounting for the inhomogeneous nature of the surface, as it was used in the experiment and analyzed as part of the reported studies. We confirm that Fl is highly v…