Search results for "ALTER"
showing 10 items of 2368 documents
Cytotoxic activity of secondary metabolites derived from Artemisia annua L. towards cancer cells in comparison to its designated active constituent a…
2010
Artemisia annua L. (sweet wormwood, qinhao) has traditionally been used in Chinese medicine. The isolation of artemisinin from Artemisia annua and its worldwide accepted application in malaria therapy is one of the showcase success stories of phytomedicine during the past decades. Artemisinin-type compounds are also active towards other protozoal or viral diseases as well as cancer cells in vitro and in vivo. Nowadays, Artemisia annua tea is used as a self-reliant treatment in developing countries. The unsupervised use of Artemisia annua tea has been criticized to foster the development of artemisinin resistance in malaria and cancer due to insufficient artemisinin amounts in the plant as c…
Naturally occurring short splice variant of CYLD positively regulates dendritic cell function
2009
Abstract Deubiquitination of NF-κB members by CYLD is crucial in controlling the magnitude and nature of cell activation. The role of the naturally occurring CYLD splice variant in dendritic cell (DC) function was analyzed using CYLDex7/8 mice, which lack the full-length CYLD (flCYLD) transcript and overexpress the short splice variant (sCYLD). Bone marrow–derived DCs from CYLDex7/8 mice display a hyperactive phenotype in vitro and in vivo and have a defect in establishing tolerance with the use of DEC-205–mediated antigen targeting to resting DCs. The combination of sCYLD overexpression and lack of flCYLD in CYLDex7/8 DCs leads to enhanced NF-κB activity accompanied by an increased nuclear…
Impacto en el sector turístico de las políticas de desarrollo rural en la Comunidad Valenciana (1991-2013). Análisis de las estrategias de fomento y …
2021
Una parte del presente artículo se presentó en forma de comunicación al XIII Coloquio de Geografía del Turismo, Ocio y Recreación, celebrado en Barcelona entre los días 14 y 16 de junio de 2012. El alojamiento en los territorios rurales valencianos experimentó un crecimiento importante durante la implantación de las iniciativas Leader, Leader 2 y Leader+, entre 1991 y 2006, así como de los programas Proder y Proder II, entre 1996 y 2006. En la Comunidad Valenciana, alrededor del 30% de las inversiones de Leader y el 16% de las inversiones de Proder se realizaron en alojamientos rurales. Finalizadas estas iniciativas y estos programas, se pone en marcha la estrategia Ruralter (2007-2013). Ve…
Análisis del comportamiento de la demanda de turismo rural desde la experiencia de la comarca El Alto Palancia
2004
This study is intended to delve into the tastes and preferences of tourists visiting rural areas in Spain as an alternative to the traditional sun and beach holiday that dominates Spanish tourism. This paper is focused on the demand side of rural tourism; more specifically the extent to which tourists visiting a Spanish rural area. El Alto Palancia region, exhibit different behaviours depending on age, gender, incomes and educational background. The homogeneity of behaviour across several categories of tourists was tested in two sets of variables. First, «interest in certain resources associated with rural tourism», focused on natural and architectural resources that sustains the tourist's …
Chionaeosides A–D, Triterpene Saponins from Paronychia chionaea
2007
Four new triterpenoid saponins, chionaeosides A-D (1-4) were isolated from the roots of Paronychia chionaea. On the basis of their spectroscopic data, the structures of the new saponins were established as 3-O-alpha-L-arabinopyranosylgypsogenic acid 28-O-beta-D-glucopyranosyl-(1--3)-beta-D-glucopyranosyl-(1--6)-beta-D-glucopyranoside (1), 3-O-alpha-L-arabinopyranosylgypsogenic acid 28-O-beta-D-glucopyranosyl-(1--6)-beta-D-glucopyranoside (2), 3-O-alpha-L-arabinopyranosylgypsogenic acid 28-O-beta-D-glucopyranoside (3), and 3-O-alpha-L-arabinopyranosylgypsogenic acid (4).
Triterpene Glycosides from the Roots of Astragalus flavescens
2007
Six new triterpene saponins, 3-O-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-xylopyranosyl-(1-->2)-beta-D-glucuronopyranosyl-21-epi-kudzusapogenol A (1), 3-O-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-glucopyranosyl-(1-->2)-beta-D-glucuronopyranosyl-21-epi-kudzusapogenol A (2), 3-O-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-xylopyranosyl-(1-->2)-beta-D-glucuronopyranosyl-22-O-beta-D-glucopyranosyl-21-epi-kudzusapogenol A (3), 3-O-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-glucopyranosyl-(1-->2)-beta-D-glucuronopyranosyl-22-O-beta-D-glucopyranosyl-21-epi-kudzusapogenol A (4), 3-O-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-xylopyranosyl-(1-->2)-beta-D-glucuronopyranosyl-22-O-alpha-L-arabinopyranosyl-21-epi-kudzus…
Effects of plant species in a horizontal subsurface flow constructedwetland – phytoremediation of treated urban wastewater withCyperus alternifolius …
2013
Abstract Plant species carry out a series of important biological, chemical and physical processes within a constructed wetland wastewater treatment system and make a significant contribution to wastewater purification. This paper compares two emergent macrophytes – Cyperus alternifolius L. and Typha latifolia L. – planted separately in a pilot horizontal subsurface flow system for the phytoremediation of treated urban wastewater in the West of Sicily (Italy). The total surface area of the three units within the pilot system was 99 m 2 . Six subunits were planted with two species and three subunits were left unplanted as the control. The main aim of the study was to demonstrate that, under …
The role of Mediterranean wetlands in climate regulation and greenhouse gases exchanges: from carbon biogeochemistry to European water and nature Dir…
2022
Atesa la seua alta activitat biogeoquímica, els aiguamolls són un dels tipus d'ecosistemes més actius en el cicle global del carboni, amb altes taxes d'intercanvi de carboni i de gasos d'efecte hivernacle (GEH), i, per tant, un gran potencial de regulació climàtica. Una de les parts més importants de la biogeoquímica del carboni als aiguamolls està lligada a les taxes metabòliques, a partir del coneixement de les quals es pot determinar un balanç de carboni associat amb el potencial intercanvi de carboni amb l'atmosfera. La seua capacitat per retindre carboni i mitigar el canvi climàtic, o, per contra, d'alliberar més GEH, i contribuir a l'escalfament global, es determina pel balanç de carb…
Il transfert di Curial
2018
Resum: I risvolti sovranazionali riscontrati nei tre protagonisti dei romanzi del Quattrocento catalano (Jacob Xalabín, Curial e Tirant) consentono di procedere a un’analisi del Curial e Güelfa che ne sottolinea l’identità multipla e l’apertura culturale del processo di formazione del protagonista, nella sua ascesa economica e sociale. L’evoluzione del protagonista, grazie a un meccanismo psicologico, oggi riconosciuto come tale, consente il lieto fine del romanzo, diversamente da quanto avviene negli altri due, dove i protagonisti, Jacob e Tirant, rimangono sempre gli stessi. Grazie allo spostamento, al transfert, Curial non rimuove quello che lo minaccia, ma riesce a superarlo, se riguard…
Una escultura de José Esteve Bonet en La Orotava (Tenerife)
2020
En septiembre de 1784 el escultor José Esteve Bonet concluía una imagen de Santa Catalina de Siena que fue remitida a la isla de Tenerife semanas después, gracias a la mediación del canónigo de Xátiva Miguel Lobera. De ese destino, el responsable del ajuste, el dinero pagado por ella y las cualidades que mostraba como pieza vestidera hay constancia en un apunte que incluye el diario o Libro de la Verdad, documento de vital importancia a la hora de conocer la actividad de su taller entre 1762 y 1802. En este artículo proponemos la identificación de dicha obra con una escultura transformada y alterada en lo iconográfico, que forma parte del patrimonio acumulado durante el siglo XIX por la act…