Search results for "ALTER"

Extensive transcriptional complexity during hypoxia-regulated expression of the myoglobin gene in cancer.

2013

Recently, the ectopic expression of myoglobin (MB) was reported in human epithelial cancer cell lines and breast tumor tissues, where MB expression increased with hypoxia. The better prognosis of MB-positive breast cancer patients suggested that the globin exerts a tumor-suppressive role, possibly by impairing mitochondrial activity in hypoxic breast carcinoma cells. To better understand MB gene regulation in cancer, we systematically investigated the architecture of the human MB gene, its transcripts and promoters. In silico analysis of transcriptome data from normal human tissues and cancer cell lines, followed by RACE-PCR verification, revealed seven novel exons in the MB gene region, mo…

Management of demolition phases and related waste, in a building renovation project near Salerno, Italy

2020

Compliance with recent environmental regulations, the demolition phase, within the building replacement process, plays a decisive role, in terms of execution and management methods. The contribution addresses the problems related to the management of the site, in compliance with regulatory requirements for selective demolition and disposal of waste materials. Possible organisational and procedural solutions were investigated with particular reference to the phases of selective demolition (in compliance with Minimum Environmental Criteria), excavation, handling, treatment, recycling, and disposal of waste materials.

La motte médiévale de Drosnay (Marne) : résultats de deux sondages archéologiques

2011

Deux opérations de diagnostic réalisées en 2008 et 2009 ont permis de mettre au jour un segment du fossé d’enceinte d’une motte répertoriée depuis le XIXe s., ainsi que les restes d’un bâtiment en pierre sur sa partie sommitale. Le fossé a livré un mobilier dont la chronologie est centrée sur le XIIIe s. alors que le bâtiment n’est pas antérieur au XVe s. Les remaniements ayant affecté ce site sont nombreux. Dès le XVe s. d’importants travaux de remblaiement et de nivellement semblent modifier l’angle sud-ouest de la motte. Cependant, ce sont les terrassements contemporains qui ont irrémédiablement détruit la plus grande part des vestiges. Seule la basse-cour peut désormais conserver des ve…

Globalizar la solidaridad

2001

El Petroleo o la vida

2002

Alternatīvās komunikācijas izmantošana bērniem ar komunikācijas traucējumiem saziņas prasmju attīstībai pirmsskolas izglītības iestādē

2018

Komunikācija nosaka cilvēku savstarpējās attiecības, tā ir būtiska bērna attīstībā. Tiek uzskatīts, ka aptuveni vienam no divpadsmit bērniem no 100 vecumā no 3 -17 gadiem ir valodas vai runas traucējumi, kas būtiski ierobežo šo bērnu kumunikāciju ar apkārtējo sabiedrību. Šie bērni bieži nespēj izteikt pat savas primārās vajadzības, kas samazina viņu pašapziņu, rada nespēju saprast citu cilvēku teikto un pilnvērtīgi iekļauties sabiedrības dzīves procesos. Daļai no šiem bērniem ir nepieciešami papildus dažādi palīglīdzekļi, kas nodrošina bērna iespēju komunicēt ar apkārtējo pasauli. Šo problēmu risināšanā tiek izmantoti dažādi alternatīvās un augmentatīvās komunikācijas metožu veidi. Maģistra…

Gene Expression Analyses during Spontaneous Reversal of Cardiomyopathy in Mice with Repressed Nuclear CUG-BP, Elav-Like Family (CELF) Activity in Hea…

2015

CUG-BP, Elav-like family (CELF) proteins regulate cell type- and developmental stage-specific alternative splicing in the heart. Repression of CELF-mediated splicing activity via expression of a nuclear dominant negative CELF protein in heart muscle was previously shown to induce dysregulation of alternative splicing, cardiac dysfunction, cardiac hypertrophy, and dilated cardiomyopathy in MHC-CELFΔ transgenic mice. A “mild” line of MHC-CELFΔ mice that expresses a lower level of the dominant negative protein exhibits cardiac dysfunction and myopathy at a young age, but spontaneously recovers normal cardiac function and heart size with age despite the persistence of splicing defects. To the b…

¿Qué hacer con la OMC?

2003

Data from: Ocean acidification affects fish spawning but not paternity at CO2 seeps

2016

Fish exhibit impaired sensory function and altered behaviour at levels of ocean acidification expected to occur owing to anthropogenic carbon dioxide emissions during this century. We provide the first evidence of the effects of ocean acidification on reproductive behaviour of fish in the wild. Satellite and sneaker male ocellated wrasse (Symphodus ocellatus) compete to fertilize eggs guarded by dominant nesting males. Key mating behaviours such as dominant male courtship and nest defence did not differ between sites with ambient versus elevated CO2 concentrations. Dominant males did, however, experience significantly lower rates of pair spawning at elevated CO2 levels. Despite the higher r…

I VARI SISTEMI ADR. STUDIO SUGLI STRUMENTI DI RISOLUZIONE ALTERNATIVA DELLE CONTROVERSIE E SUI RAPPORTI CON IL PROCESSO GIURISDIZIONALE

2011

Lo scritto esamina la mediazione delle controversie come strumento di ADR (alternative duispute resolution) e segnala le notevoli differenze tra le disposizioni sulla mediazione e gli strumenti di ADR che sono vigenti in altri paesi. Vengono inotlre sollevati dubbi di legittimità costituzionale della recente disciplina introdotta in Italia dalle disposizioni in materia di mediazione.