Search results for "ALTER"

Cytotoxicity of the bisphenolic honokiol from Magnolia officinalis against multiple drug-resistant tumor cells as determined by pharmacogenomics and …

2014

A main problem in oncology is the development of drug-resistance. Some plant-derived lignans are established in cancer therapy, e.g. the semisynthetic epipodophyllotoxins etoposide and teniposide. Their activity is, unfortunately, hampered by the ATP-binding cassette (ABC) efflux transporter, P-glycoprotein. Here, we investigated the bisphenolic honokiol derived from Magnolia officinalis. P-glycoprotein-overexpressing CEM/ADR5000 cells were not cross-resistant to honokiol, but MDA-MB-231 BRCP cells transfected with another ABC-transporter, BCRP, revealed 3-fold resistance. Further drug resistance mechanisms analyzed study was the tumor suppressor TP53 and the epidermal growth factor recepto…

Determination of Alternaria mycotoxins in strawberries and storage conditions

2014

The Long Route Towards a Widespread European Culture of Alternatives to Immigration Detention

2016

The aim of this article is to provide an analysis of the application by some European Union countries of alternative measures to detention of migrants. Sections 2 and 3 indicate, in line with European normatives and with detention being a measure of last resort, that Member States having ascertained that there are grounds for the detention of migrants, should evaluate whether the aims pursued can be achieved through a less coercive measure which respects the fundamental rights of individuals. Unfortunately, as examined in Section 4, analysis of most European countries’ law reveals an unsatisfactory application of alternative measures to detention. As in, for example, Italy’s case, whose leg…

Effect of plant species on water balance in a pilot-scale horizontal subsurface flow constructed wetland planted with Arundo donax L. and Cyperus alt…

2015

Abstract In constructed wetland systems (CWs) for wastewater treatment, evapotranspiration (ET) is the most important water balance component in arid and semi-arid regions, where high performance levels are needed when treating contaminants and where it is also vital to preserve as much water as possible for reuse in irrigation. This study shows the results of a series of water balance measurements obtained between 2012 and 2013 from a pilot HSSF system in the West of Sicily (Italy). The system was made by two separate vegetated units: one with Arundo donax L. (giant reed) and the other with Cyperus alternifolius L. (umbrella sedge), and fed with urban wastewater following secondary treatme…

Fumarolic alteration products at Sousaki (Greece) : occurrence and environmental impact

2009

Fumarolic alteration crusts and efflorescences have been sampled at the Sousaki solfataric field. Samples have been analysed for mineralogical (XRD) and chemical composition (HNO3 digestion and leaching with distilled water). Results show that mineralogical and chemical compositions (major, minor and trace metals) are controlled by microenvironmental conditions. The sample collected in the anoxic part of a cave is composed almost exclusively by native sulfur. The samples collected in the oxidizing part of the cave and outside in relatively sheltered position are mainly composed by very soluble sulfates. Chemical composition evidence strong enrichments in Al, Ca, Cr, Fe, Mg and Ni which are …

Fumarolic alteration products of three hydrothermal areas of Greece: Chemical characterization and environmental impact.

2018

Samples of efflorescences and encrustations of hydrothermal origin have been collected at three fumarolic areas in Greece. The three sites are Sousaki, Thiafi (Methana) and Kokkino Nero (Kos) and all belong to the South Aegean Active Volcanic Arc. Samples were analysed for their mineralogical (XRD and SEM-EDS) and chemical composition. Solutions obtained from both mineralization with HNO3 and leaching with distilled water, were analysed for major (ICP-OES), minor and trace metals (ICP-MS) and for sulfate contents (IC). Results show that their composition is mainly controlled by the petrological composition of the substrate (ultramafic rocks at Sousaki, felsic volcanic rocks at Methana and l…

Current neuroscientific research database findings of brain activity changes after hypnosis.

2021

Using multi-modal brain imaging techniques we found pronounced changes in neuronal activity after hypnotic trance induction whereby state changes seem to occur synchronously with the specific induction instructions. In clinical patients, hypnosis proved to be a powerful method in inhibiting the reaction of the fear circuitry structures. The aim of the present paper is to critically discuss the limitations of the current neuroscientific research database in the light of a debate in defining relevant hypnotic constructs and to suggest ideas for future research projects. We discuss the role of hypnotic suggestibility (HS), the impact of hypnotic inductions and the importance of the depth of hy…

Analgesic hypnotic treatment in a post-stroke patient

2021

In recent years, hypnotic suggestions have been used in several clinical conditions. This treatment is often used for anxiety treatment, somatization, and post-traumatic stress disorder. Hypnotic analgesia is one of the most clinically useful phenomena of hypnosis. The article describes the case of a patient who underwent hypnotic treatments for hypersensitivity and chronic pain. Results showed an improvement of pain control and a decrease of pain hypersensibility. In addition, during rehabilitative treatments, the patient reported a high level of compliance with the multidisciplinary team. These findings suggest that hypnosis could be a useful treatment for post-stroke pain management.

Medicinal Plants in the Treatment of Depression. II: Evidence from Clinical Trials

2021

AbstractDepression is a syndrome characterized by deep sadness and the inhibition of psychic functions, sometimes accompanied by neurovegetative disorders, with symptoms of anxiety almost always present. The disease produces alterations in a variety of neural networks and neurotransmission systems, along with a dysfunction of the hypothalamic-pituitary-adrenal axis, which leads to concomitant alterations in the immunological response. Generally, there is a parallel increase in proinflammatory mediators as well as oxidative and nitrosative damage caused by a reduction of antioxidant defenses. In a previous review, we compiled and examined studies of medicinal plants that had been evaluated i…

Identità e alterità. Il lungo viaggio di Gabriella Ghermandi, Cristina Ali Farah, Igiaba Scego, Ornela Vorpsi

2015

L’analisi parallela delle opere di quattro scrittrici della migrazione consente di individuare, nella singolarità delle scritture, una circolarità di discorso sui temi del viaggio e dello spaesamento, del racconto e della lingua.. Il saggio mette in evidenza come lo «statuto relazionale dell’identità» viva in rapporto a quello dell’alterità e si configuri come un’identità multipla che si realizza in uno spazio mobile. Il lungo viaggio di Gabriella Ghermandi, Cristina Ali Farah, Igiaba Scego e Ornela Vorpsi illustra, con diversi esiti, la trasformazione del tema dell’esilio in quello della perenne erranza. Dalla loro esperienza della migrazione, dalla loro condizione nomade, emergono narrazi…