Search results for "ALZHEIMER'S DISEASE"
showing 10 items of 301 documents
Immune-inflammatory responses in alzheimer's disease: therapeutic implications.
2011
A SOCIAL EXPERIMENT TO OVERTURN PREJUDICES ON ALZHEIMER’S DISEASE IN NURSING HOMES USING ARTISTIC PHOTOGRAPHY
2016
It is widely known that Alzheimer’s disease is burdened with strong prejudices with negative connotations. This may contribute to increase patient’s isolation and marginalization, and to render Nursing Homes places of confinement and seclusion. Residents with dementia have trouble in relating with the outside world and in expressing themselves about their own disease, due to their cognitive decline, but also because of marginalization. We used artistic photography as an accessible and effective tool to bring down barriers and encourage residents’ communication. Artistic photography is the most immediate and accessible form of art for all people. The aim of our social experiment was to help …
Combination of intensive cognitive rehabilitation and donepezil therapy in Alzheimer’s disease.
2009
Tumor diagnosis preceding Alzheimer’s disease: a case-control study
2011
Oral health status and periodontitis in Alzheimer's disease patients: A case control Study in a Sicilian rural community
2014
Aim. Dementia is a common disorder among the elderly. Alzheimer’s disease (AD) is the most common cause of dementia. In addition to known risk factors (e.g. age and familiarity) of AD, recently it has been suggested a possible promoting role for chronic inflammatory infective diseases. Periodontal disease (PD) is a frequent chronic multi-bacterial infection involving the tissues supporting the teeth; in addition to promoting inflammation locally, the periodontal pathogens possess mechanisms able to influence the systemic balance of inflammatory mediators. Similarly to other systemic diseases (e.g. cardiovascular disease, diabetes, renal diseases and low birth weight), a possible link has be…
Antidiabētiska līdzekļa metformīna neirorestoratīvo efektu izpēte eksperimentāli izveidotajā Alcheimera slimības modelī
2022
levads. Glikozes metabolisma traucējumi un kognitīvie traucējumi ir vienas no agrīnām sporādiskās Alcheimera slimibas (sAD) pazīmēm. Agrīna terapeitiskā iejaukšanās varētu apstādināt kognitīvos traucējumus pirms sAD progresēšanas. Metformīns, visplašāk zināms pretdiabeta līdzkelis, ir uzrādījis spēju uzlabot kognitīvās funkcijas un glikozes metabolismu otra tipa diabēta pacientos un diabēta modeļdzīvniekos. Intranazālais ievadīšanas veids ļauj samazinaāt preparāta devu un mazina blakusparadibu izpausmes. Pie tam, metformīns šķērso hematoencefālisko barjeru un ir spējīgs izplatīties smadzenēs pēc vienreizējās ievadīšanas. Intranazālas metformīna ievadīšanas efekti uz sociālo uzvedību iepriek…
The Erythrocytic Hypothesis of Brain Energy Crisis in Sporadic Alzheimer Disease: Possible Consequences and Supporting Evidence
2020
Alzheimer’s disease (AD) is a fatal form of dementia of unknown etiology. Although amyloid plaque accumulation in the brain has been the subject of intensive research in disease pathogenesis and anti-amyloid drug development; the continued failures of the clinical trials suggest that amyloids are not a key cause of AD and new approaches to AD investigation and treatment are needed. We propose a new hypothesis of AD development based on metabolic abnormalities in circulating red blood cells (RBCs) that slow down oxygen release from RBCs into brain tissue which in turn leads to hypoxia-induced brain energy crisis; loss of neurons; and progressive atrophy preceding cognitive dysfunction. This …
A novel mutation (Thr116IIe) in the presenilin 1 gene in a patient with early-onset Alzheimer's disease
2004
We report a novel presenilin 1 (PSN1) mutation (Thr116Ile) in a woman with early onset Alzheimer's disease (AD). This mutation was not found in 100 healthy controls, indicating that this is not a common polymorphism. The patient presented with forgetfulness at age 45, followed over the next 3 years by a worsening of the memory loss and frequent episodes of confusion and spatial disorientation. Neuroimaging studies were consistent with AD. The analysis of the family's pedigree showed that the proband was apparently the only member affected. Because the early death of several close relatives (i.e. the mother and the grandmother) and the demonstration that the father is not a mutation carrier,…
Changes in visual function and retinal structure in the progression of Alzheimer's disease
2019
Background Alzheimer's Disease (AD) can cause degeneration in the retina and optic nerve either directly, as a result of amyloid beta deposits, or secondarily, as a result of the degradation of the visual cortex. These effects raise the possibility that tracking ophthalmologic changes in the retina can be used to assess neurodegeneration in AD. This study aimed to detect retinal changes and associated functional changes in three groups of patients consisting of AD patients with mild disease, AD patients with moderate disease and healthy controls by using non-invasive psychophysical ophthalmological tests and optical coherence tomography (OCT). Methods We included 39 patients with mild AD, 2…
Le fractionnement de la métamémoire dans la maladie d'Alzheimer
2017
Alzheimer's disease is characterized by memory deficits. However, only a few studies have explored how patients judge their memory difficulties. The main aim of this thesis is to determine in more details whether or not Alzheimer’s patients have impaired metamnesic abilities (knowledge about own memory). Indeed, previous studies showed a complex pattern of results and suggested a fractionation of metamemory in Alzheimer’s disease (Souchay, 2007). Therefore, the main aim of this thesis is to explore this fractionation in more details and to explore whether it can be observed (1) between long-term memory tasks and short-term memory tasks, (2) according to the type of response (judgment of lea…