Search results for "AMS"
showing 10 items of 1497 documents
Radioactive Beams for Image-Guided Particle Therapy : The BARB Experiment at GSI
2021
Several techniques are under development for image-guidance in particle therapy. Positron (β+) emission tomography (PET) is in use since many years, because accelerated ions generate positron-emitting isotopes by nuclear fragmentation in the human body. In heavy ion therapy, a major part of the PET signals is produced by β+-emitters generated via projectile fragmentation. A much higher intensity for the PET signal can be obtained using β+-radioactive beams directly for treatment. This idea has always been hampered by the low intensity of the secondary beams, produced by fragmentation of the primary, stable beams. With the intensity upgrade of the SIS-18 synchrotron and the isotopic separati…
Empirical analysis of daily cash flow time-series and its implications for forecasting
2019
Usual assumptions on the statistical properties of daily net cash flows include normality, absence of correlation and stationarity. We provide a comprehensive study based on a real-world cash flow data set showing that: (i) the usual assumption of normality, absence of correlation and stationarity hardly appear; (ii) non-linearity is often relevant for forecasting; and (iii) typical data transformations have little impact on linearity and normality. This evidence may lead to consider a more data-driven approach such as time-series forecasting in an attempt to provide cash managers with expert systems in cash management.
On Language Adequacy
2015
Abstract The paper concentrates on the problem of adequate reflection of fragments of reality via expressions of language and inter-subjective knowledge about these fragments, called here, in brief, language adequacy. This problem is formulated in several aspects, the most general one being: the compatibility of the language syntax with its bi-level semantics: intensional and extensional. In this paper, various aspects of language adequacy find their logical explication on the ground of the formal-logical theory of syntax T of any categorial language L generated by the so-called classical categorial grammar, and also on the ground of its extension to the bi-level, intensional and ex- tensio…
COMPOSITION AND QUALITY OF FRESHWATER LAKE SEDIMENTS (BALVU AND PĒRKONU LAKES)
2019
Water quality, watershed basin and urbanization are key factors from the perspective of freshwater management; however, actual depth of waterbodies is often an overlooked element. Actual depth represents the overall depth of lake bed and depth of sediments. Some cases have been reported, where with increase of average depth of lake , it is possible to expect improvements of water quality when sediments are removed. If lakes are eutrophic, shallow, overgrown with macrophytes and contain high concentrations of biogenic elements water and lake ecosystem quality can be endangered. Removal of sediments can be an expensive procedure and also depends on the composition, structure, local conditions…
Independent Generation of Aβ42 and Aβ38 Peptide Species by γ-Secretase
2008
Proteolytic processing of the amyloid precursor protein by beta- and gamma-secretase generates the amyloid-beta (Abeta) peptides, which are principal drug targets in Alzheimer disease therapeutics. gamma-Secretase has imprecise cleavage specificity and generates the most abundant Abeta40 and Abeta42 species together with longer and shorter peptides such as Abeta38. Several mechanisms could explain the production of multiple Abeta peptides by gamma-secretase, including sequential processing of longer into shorter Abeta peptides. A novel class of gamma-secretase modulators (GSMs) that includes some non-steroidal anti-inflammatory drugs has been shown to selectively lower Abeta42 levels withou…
Stable Expression of Heterologous Sulfotransferase in V79 Cells: Activation of Primary and Secondary Benzylic Alcohols
1994
Abstract A sulfotransferase (ST) capable of activating 1-hydroxymethylpyrene (HMP) and 9-hydroxymethylanthracene (HMA) to mutagens was purified from rat liver. This enzyme appeared to be identical with hydroxysteroid STa, whose cDNA was cloned and stably expressed in Chinese hamster V79 cells. Several primary and secondary benzylic alcohols derived from polycyclic aromatic hydrocarbons induced gene mutations, sister chromatid exchanges (SCE) and/or cytotoxicity in these cells.
Novel host-specific iron acquisition system in the zoonotic pathogenVibrio vulnificus
2015
Summary Vibrio vulnificus is a marine bacterium associated with human and fish (mainly farmed eels) diseases globally known as vibriosis. The ability to infect and overcome eel innate immunity relies on a virulence plasmid (pVvbt2) specific for biotype 2 (Bt2) strains. In the present study, we demonstrated that pVvbt2 encodes a host-specific iron acquisition system that depends on an outer membrane receptor for eel transferrin called Vep20. The inactivation of vep20 did not affect either bacterial growth in human plasma or virulence for mice, while bacterial growth in eel blood/plasma was abolished and virulence for eels was significantly impaired. Furthermore, vep20 is an iron-regulated ge…
Microcirculatory Dysfunction Induced by Cigarette Smoking
2000
This review deals with the deleterious effects of cigarette smoking on the microcirculation, both in terms of morphological (i.e., vessel wall injury, capillary loss) and functional aspects. The latter concerns predominantly changes in tissue perfusion and its regulatory mechanisms (i.e., reactive hyperemia, sequestration of blood cells in the microcirculation). The mechanisms of action of cigarette smoking on the microcirculation include compromised endothelial-dependent vasorelaxation, platelet aggregation, endothelial cell dysfunction, and the activation of circulating leukocytes. Through these mechanisms, cigarette smoking elicits the aggregation and adhesion of leukocytes and/or platel…
Optical remote sensor for alcohol concentration in blood
2012
In this paper we incorporate recently developed novel optical approach for extraction of remote vibration sources to estimate the alcohol concentration in blood stream.
Sieviete-ieslodzītā Latvijas Republikas cietumos, 1919-1921.gadā
2015
Pētījums veltīts līdz šim latviešu historiogrāfijā maz pētītām tēmām – cietumu un sieviešu vēsturei. Maģistra darba mērķis ir sniegt Latvijas Republikas Tieslietu ministrijai pakļautajos cietumos un arestnamos ievietoto sieviešu ieslodzījuma raksturojumu un sociālo portretu Galvenās cietumu valdes darbības sākumā (1919.–1921. gada 16. aprīlis), konstatējot galvenās soda izciešanas tendences, sniedzot ieslodzīto sieviešu sociālo raksturojumu, kā arī kā piemērus aplūkojot atsevišķu personu pieredzi. Neatkarības kara laikā un pēckara gados vērojama tendence sievietēm aktīvi darboties dažādās noziedzīgās jomās, turklāt jaunā kvalitātē, kas pirms Pirmā pasaules kara nebūtu iedomājama. To apstipr…