Search results for "ANATOMIA"
showing 10 items of 1108 documents
Circulating hemocytes and pharyngeal explants of Styela clava release hemagglutinin in vitro
1997
Tunicate blood cells are a mixed population, thus experiments that assay their immunodefense responses, such as release of hemagglutinins, were done to isolate different functional hemocytic types. Two sources of hemocytes from Styela clava were used, the hemolymph and the pharynx (the hemopoietic organ). Hemolymph centrifuged through a discontinuous Percoll gradient yielded four distinct bands of hemocytes. After incubation at 15°C, circulating hemocytes and those from pharyngeal cultures released hemagglutinin after 2 and 30 days. Highest titers were found in B1 (hyaline and compartment cells), B3 (hyaline cells and eosinophil granulocytes), and B4 (hyaline cells and debris). Hemagglutina…
CCL5(RANTES) inhibits TGFbeta1 induced collagen production in human bronchial epithelial cells by action of Smad protein
2009
Airway epithelial cells modulate bronchial remodelling in COPD and asthma. TGF-β1 up-regulation was observed in the bronchial epithelial cells of asthmatics and COPD patients. TGF-β is involved in airways remodelling mainly acting via the Smad pathway. Increased CCL5 was also observed in bronchi of patients with severe COPD. We investigated the effects of TGF-β1 on collagen type I, Smad 3-4 and 7 expression and the effects of CCL5 on TGF-β1-induced collagen production in human bronchial epithelial cells (16HBE).Cells were treated with 10ng/ml of TGF-β1, 10ng/ml of CCL5 and 10ng/ml of both TGF-β1 and CCL5 for 0,3 and 24 hours.TGF-b1 increased Smad3,Smad4 and collagen type I(p=0.0472, p=0.043…
TGFbeta signaling: roles of Smads
2009
EMODINAMICA DEL TALAMO
2009
Extracellular vesicles in airway homeostasis and pathophysiology
2021
The epithelial–mesenchymal trophic unit (EMTU) is a morphofunctional entity involved in the maintenance of the homeostasis of airways as well as in the pathogenesis of several diseases, including asthma and chronic obstructive pulmonary disease (COPD). The “muco-microbiotic layer” (MML) is the innermost layer of airways made by microbiota elements (bacteria, viruses, archaea and fungi) and the surrounding mucous matrix. The MML homeostasis is also crucial for maintaining the healthy status of organs and its alteration is at the basis of airway disorders. Nanovesicles produced by EMTU and MML elements are probably the most important tool of communication among the different cell types, inclu…
Effects of essential oils and selected compounds from Lamiaceae family as adjutants on the treatment of subjects with periodontitis and cardiovascula…
2021
Essential oils from different plant species were found to contain different compounds exhibiting anti-inflammatory effects with the potential to be a valid alternative to conventional chemotherapy that is limited in long-term use due to its serious side effects. Generally, the first mechanism by which an organism counteracts injurious stimuli is inflammation, which is considered a part of the innate immune system. Periodontitis is an infectious and inflammatory disease caused by a dysbiosis in the subgingival microbiome that triggers an exacerbated immune response of the host. The immune–inflammatory component leads to the destruction of gingival and alveolar bone tissue. The main anti-infl…
Molecular profile study of extracellular vesicles for the identification of useful small “hit” in cancer diagnosis
2021
Tumor-secreted extracellular vesicles (EVs) are the main mediators of cell-cell communication, permitting cells to exchange proteins, lipids, and metabolites in varying physiological and pathological conditions. They contain signature tumor-derived molecules that reflect the intracellular status of their cell of origin. Recent studies have shown that tumor cell-derived EVs can aid in cancer metastasis through the modulation of the tumor microenvironment, suppression of the immune system, pre-metastatic niche formation, and subsequent metastasis. EVs can easily be isolated from a variety of biological fluids, and their content makes them useful biomarkers for the diagnosis, prognosis, monito…
Studio dell’apoptosi in oociti umani.
2017
Gli obiettivi delle ricerche condotte sono stati duplici: 1) verificare l’eventuale comparsa o aumento di fenomeni apoptotici nelle cellule follicolari, negli oociti e nelle strutture stromali, di tessuto ovarico sottoposto a criopreservazione. 2) verificare la presenza di apoptosi in oociti non fecondati dopo trattamento ICSI (Intra Citoplasmic Sperm Injection), per comprendere se pregressi eventi apoptotici siano già in atto in oociti umani trattati con tecniche avanzate di fecondazione assistita, e possano pertanto essere la causa della mancata fecondazione di circa il 30-35 % degli oociti trattati.
FISICA QUANTISTICA E FUNZIONI MENTALI SUPERIORI III
2010
Questo saggio riprende alcuni concetti di anatomia comparata e di fisiologia, sviluppati in una mia precedente ricerca dal titolo Termodinamica, campi quantici e funzioni mentali. Il fine è di chiarire alcuni punti controversi posti dall’analisi scientifica, in riguardo a teoremi di neuro anatomia e di neurofisiologia. Il filosofo Heiddegger H. riteneva che il pensiero umano non può affidarsi interamente all’indagine scientifica, traducendo in schemi ed in formule la vivente realtà della natura, sia fisica che biologica. La ricerca scientifica si basa su un sapere rigoroso e preciso, altamente dimostrativo che può competere con la matematica, ritenuta la scienza delle scienze. Nonostante ci…
FISICA QUANTISTICA E FUNZIONI CEREBRALI SUPERIORI (II)
2010
Data una semplice perturbazione, il processo lineare tende a rimanere leggermente alterato. Data la stessa perturbazione, un processo non lineare tende a tornare al suo punto di partenza. Huygens C. (fisico olandese del XVI sec.) inventò l’orologio a pendolo e la disciplina classica della dinamica. S’imbatté in uno dei grandi esempi di questa forma di regolazione. Huygens notò che vari orologi a pendolo, appoggiati contro una parete stavano oscillando in modo perfettamente sincronizzato. Sapeva che gli orologi non potevano essere così precisi. Huygens ipotizzò che gli orologi fossero coordinati da vibrazioni trasmesse attraverso la parete. Al presente, il fenomeno è definito agganciamento d…