6533b7d0fe1ef96bd125ae8b
RESEARCH PRODUCT
Extracellular vesicles in airway homeostasis and pathophysiology
Domenico Michele ModicaStefano BurgioFabio BucchieriAlessandro PitruzzellaAlberto FucarinoMaria Concetta ZarconeFrancesco Cappellosubject
TechnologyCell typenanovesiclesQH301-705.5QC1-999Asthma Chronic obstructive pulmonary diseaseCOPDEpithelial–mesenchymal trophic unitExosomesMicrobiota Muco-microbiotic layer nanovesicles Outer membrane vesicles.Biologychronic obstructive pulmonary diseasePathogenesismedicineCOPDGeneral Materials ScienceBiology (General)QD1-999InstrumentationAsthmaFluid Flow and Transfer ProcessesCOPDSettore BIO/16 - Anatomia UmanaTPhysicsProcess Chemistry and TechnologyGeneral EngineeringasthmaEngineering (General). Civil engineering (General)medicine.diseasemuco-microbiotic layerMicrovesiclesPathophysiologyrespiratory tract diseasesComputer Science ApplicationsChemistryepithelial–mesenchymal trophic unitImmunologyTA1-2040AirwayHomeostasisdescription
The epithelial–mesenchymal trophic unit (EMTU) is a morphofunctional entity involved in the maintenance of the homeostasis of airways as well as in the pathogenesis of several diseases, including asthma and chronic obstructive pulmonary disease (COPD). The “muco-microbiotic layer” (MML) is the innermost layer of airways made by microbiota elements (bacteria, viruses, archaea and fungi) and the surrounding mucous matrix. The MML homeostasis is also crucial for maintaining the healthy status of organs and its alteration is at the basis of airway disorders. Nanovesicles produced by EMTU and MML elements are probably the most important tool of communication among the different cell types, including inflammatory ones. How nanovesicles produced by EMTU and MML may affect the airway integrity, leading to the onset of asthma and COPD, as well as their putative use in therapy will be discussed here.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-10-01 |