Search results for "ANKI"

2014

This paper investigates the proficiency of support vector machine (SVM) using datasets generated by Tennessee Eastman process simulation for fault detection. Due to its excellent performance in generalization, the classification performance of SVM is satisfactory. SVM algorithm combined with kernel function has the nonlinear attribute and can better handle the case where samples and attributes are massive. In addition, with forehand optimizing the parameters using the cross-validation technique, SVM can produce high accuracy in fault detection. Therefore, there is no need to deal with original data or refer to other algorithms, making the classification problem simple to handle. In order to…

2014

The majority of next-generation sequencing short-reads can be properly aligned by leading aligners at high speed. However, the alignment quality can still be further improved, since usually not all reads can be correctly aligned to large genomes, such as the human genome, even for simulated data. Moreover, even slight improvements in this area are important but challenging, and usually require significantly more computational endeavor. In this paper, we present CUSHAW3, an open-source parallelized, sensitive and accurate short-read aligner for both base-space and color-space sequences. In this aligner, we have investigated a hybrid seeding approach to improve alignment quality, which incorp…

Role and importance of polymorphisms with respect to DNA methylation for the expression of CYP2E1 enzyme

2014

Different individuals possess slightly different genetic information and show genetically-determined differences in several enzyme activities due to genetic variability. Following an integrated approach, we studied the polymorphisms and methylation of sites contained in the 5' flanking region of the metabolizing enzyme CYP2E1 in correlation to its expression in both tumor and non-neoplastic liver cell lines, since to date little is known about the influence of these (epi)genetic elements in basal conditions and under induction by the specific inductor and a demethylating agent. In treated cells, reduced DNA methylation, assessed both at genomic and gene level, was not consistently associate…

General Overview

2016

Il capitolo introduce alla tematica smart city attraverso un exscursus storico che ne traccia i passaggi salienti: la nascita delle politiche globali ambientali sino al livello della maturità raggiunto con il Protocollo di Kyoto (1997); poi ancora il Pacchetto Clima 20-20-20 redatto dalla Commissione Europea nel 2008 che traccia un'altro punto cruciale che prelude ai progetti e alle iniziative in ambito smart cities. La Strategia Energetica Europea al 2050 rappresenta il quadro di riferimento a cui tendere. Il capitolo si conclude con una rassegna dei sistemi di ranking più popolari e con una proposta di analisi. The chapter introduces to smart city issue through a historical excursus, whic…

Svarīgāko klīnisko faktoru ietekme uz pacientu ārstēšanas rezultātu pie spontānām intracerebrālām hematomām

2018

Spontānas intracerebrālas hematomas sastāda 15% no visiem insultiem pieaugušo vecumā, bet šīs pataloģijas letalitāte pirmā mēneša laikā atbilst 40%. Pēdējās vadlīnijas (2015. gada) saglabājas daudz neskaidru jautājumu par optimālo terapiju, izvēles taktiku intracerebrālas hematomas ārstēšanā. Pētījuma mērķis: uzlabot pacientu stāvokļa novērtēšanu un attiecīgās ārstēšanas pielāgošanu pacientiem. Pētījuma rezultāti: Funkcionālais iznākums korelē ar GKS(r=0,5), spontānas intracerebrālas hematomas tilpumu (r=0,4) un smadzeņu viduslīnijas dislokācija (r=0,3). Spontānas intracerebrālas hematomas tilpums (p<0,0001), smadzeņu viduslīnijas dislokācija (p<0,0001), intraventrikulārās hemorāģijas esamī…

Reconsidering authorship in the Ciceronian corpus through computational authorship attribution

2019

In recent years, methods of computational authorship attribution have offered promising results for the reattribution of classical texts. We use and further develop these methods to verify the authorship of several texts belonging or related to the Ciceronian corpus: Rhetorica ad C. Herennium, De inventione, De optimo genere oratorum, and Commentariolum petitionis. We use two classifiers, Support Vector Machine and Convolutional Neural Network, of which the latter is more accurate except in regard to certain aspects of vocabulary. The most important of our results is that Commentariolum petitionis seems to be authored by Marcus Cicero, not by his brother Quintus. Negli ultimi anni metodi co…

European Banking Union and bank risk disclosure: the effects of the Single Supervisory Mechanism

2022

AbstractThis paper provides evidence on the impact of European Banking Union (BU) and the associated Single Supervisory Mechanism (SSM) on the risk disclosure practices of European banks. The onset of BU and the associated rules are considered as an exogenous shock that provides the setting for a natural experiment to analyze the effects of the new supervisory arrangements on bank risk disclosure practices. A Difference-in-Differences approach is adopted, building evidence from the disclosure practices of systemically important banks supervised by the European Central Bank (ECB) and other banks supervised by national regulators over the period 2012–2017. The main findings are that bank risk…

Recent Advances in Derivation of Functional Hepatocytes from Placental Stem Cells

2013

Abstract: End-stage liver diseases are one of the leading causes of death in the world. Often orthotopic liver transplantation represents the final therapeutic choice. The limits of this approach are the scarcity of donor livers available, and the many side effects related to the administration of immune suppressants to the patients. Cellular therapy for liver diseases is increasingly being viewed as a promising strategy to provide hepatocytes to replenish the parenchymal cells of the organ. This technique suffers of some important limitations, such as the difficulty in isolating sufficient cell numbers (e.g. when adult or foetal hepatocytes are used for transplantation), the limited viabil…

2018

The objective of this article is to study some of the intended and unintended effects on academe of the evolving global ranking game. I will start with some broader points on the global ranking gam...

Universities' Reporting on SDGs: Using THE Impact Rankings to Model and Measure Their Contribution to Sustainability

2021

Higher education institutions (HEIs) have voiced growing concerns about sustainability issues since Agenda 2030 was approved, but this is not enough for societal stakeholders seeking and delivering innovation and excellence. The 17 Sustainable Development Goals (SDGs) were adopted by all UN Member States in 2015 as a universal call to action, and pose a challenge for HEIs as for the efforts made to fulfill them and knowing how to assess their performance. However, the metric management system implemented by HEIs quickly led to rankings emerging, which compare HEIs to metrics not related to the sustainability dimensions of the 17 SDGs. The main aim of the paper is to assess the level of repo…