Search results for "ANR"

Akadēmiskā Dzīve, 44.krājums

2007

Htoniskā pasaule Lūkiāna tekstos: žanru iezīmes mīta funkcionalitātes aspektā

2018

Maģistra darba Htoniskā pasaule Lūkiāna tekstos: žanru iezīmes mīta funkcionalitātes aspektā mērķis ir apzināt un izpētīt htonisko pasauli Lūkiāna tekstos, novērtējot tās klātbūtni, nozīmi un uzdevumus attiecīgā žanra ietvaros. Darba teorētiskajā daļā tiek skaidrots jēdziens htonisks un aplūkota htoniskās pasaules koncepcija antīkās pasaules ietvaros. Tāpat apskatīti mīta un žanru teorijas aspekti, kā arī būtiskākās autora literārās darbības gaitas. Praktiskajā daļā klasificējot, identificējot un kontekstuāli izvērtējot, tiek apskatīts htoniskās pasaules un tās elementu attēlojums Lūkiāna darbos. Tāpat aplūkotas un izvērtētas literāro žanru iezīmes, kuras parādās identificēto elementu ietva…

Nanosuspension Formulations for Low-Soluble Drugs: Pharmacokinetic Evaluation Using Spironolactone as Model Compound

2005

Various particle sizes of spironolactone as a model low solubility drug were formulated to yield micro-and nanosuspensions of the type solid lipid nanoparticles and DissoCubes. Seven oral and one i.v. formulations were tested in an in vivo pharmacokinetic study in rats with the aim of characterizing the bioavailability of spironolactone on the basis of its metabolites canrenone and 7-alpha-thiomethylspirolactone. In addition, a dose escalation study was carried out using nonmicronized spironolactone suspension as well as a nanosuspension type DissoCubes. On the basis of AUC as well as Cmax ratios, three groups of formulations were distinguished. The biggest improvement was seen with a solid…

Lanreotide Therapy vs Active Surveillance in MEN1-Related Pancreatic Neuroendocrine Tumors2 Centimeters.

2019

Abstract Purpose Pancreatic neuroendocrine tumors (pNETs) are frequent in multiple endocrine neoplasia type 1 (MEN1) syndrome. They are usually not surgically treated unless larger than 1 to 2 cm or a growth rate > 0.5 cm per year. Somatostatin analogues represent one of the main therapeutic options in pNETs, but they have never been prospectively investigated in MEN1-related pNETs. The aim of this study was to prospectively evaluate the effectiveness of lanreotide in patients with MEN1-related pNETs < 2 cm. Methods MEN1 patients with 1 or more pNETs < 2 cm of maximal diameter were considered. Study design was prospective observational, comparing patients treated with l…

Nonconventional Doses of Somatostatin Analogs in Patients With Progressing Well-Differentiated Neuroendocrine Tumor

2020

Abstract Purpose To evaluate the antiproliferative activity and safety of nonconventional high doses of somatostatin analogs (HD-SSA) in patients with well-differentiated gastroenteropancreatic (GEP) neuroendocrine tumors (NET) with radiological disease progression according to Response Evaluation Criteria in Solid Tumors (RECIST) criteria on a previous treatment. Methods A retrospective analysis of prospectively maintained databases from 13 Italian NET-dedicated centers was performed. Main inclusion criteria were: well-differentiated G1 or G2 GEP-NET, progressive disease on a previous treatment, and subsequent treatment with HD-SSA (either by increased administered dose [dose intensity] or…

Effects of canrenoate plus angiotensin-converting enzyme inhibitors versus angiotensin-converting enzyme inhibitors alone on systolic and diastolic f…

2004

Background Aldosterone (ALDO) exerts profibrotic effects, acting via the mineralocorticoid receptors in cardiovascular tissues. Aldosterone antagonism in combination with angiotensin-converting enzyme inhibition may better protect against the untoward effects of ALDO than angiotensin-converting enzyme inhibition alone. Methods In a double-blind randomized study, the tolerability and efficacy of canrenoate (25 mg/d) plus captopril versus captopril alone were evaluated in 510 patients with an acute anterior myocardial infarction (MI), a serum creatinine concentration 5.5 mEq/L and creatinine levels to >2.0 mg/L after 10 days of treatment were observed. At 180 days, the mitral E-wave–A-wave ra…

The combination ace-inhibitors plus canreonate in patients with anterior myocardial infarction: safety and tolerability study.

2001

There is recent evidence that aldosterone (ALDO) exerts pro-fibrotic effects, acting via the mineral-corticoid receptors in cardiovascular tissues and partial aldosterone escape during ACE-inhibition treatment occurs.A double blind randomised study was performed to evaluate the feasibility, and tolerability of the administration of the 25 mg/day of canreonate plus captopril versus captopril alone in patients with anterior AMI unsuitable for thrombolysis and/or not receiving thrombolytic treatment, and unreperfused after thrombolysis. Fifty five patients hospitalised for anterior AMI,with a serum creatinine concentration2.0 mg/dl and a serum K concentration5.0 mmol per liter were randomised …

Assessing Online Collaborative Problem Solving Among School Children in Finland : A Case Study Using ATC21S TM in a National Context

2018

Online collaborative problem-solving tasks were piloted in five Finnish schools participating in the Assessment and Teaching of Twenty-first Century Skills (ATC21STM) project. Process stream data from online tasks were captured from 480 Finnish students who explored dyad problem spaces. The log file data were explored to identify indicative behaviours of collaborative problem solving (CPS), which were coded into a series of dichotomous indicators. The Rasch simple logistic model was used to analyse student performance across the social and cognitive dimensions of CPS. Analysis of the Finnish data indicated that the construct can be interpreted using a two-dimensional model, matching the fin…

Integrated Cleanroom Process for the Vapor-Phase Deposition of Large-Area Zeolitic Imidazolate Framework Thin Films

2019

Chemistry of materials XX(XX), acs.chemmater.9b03435 (2019). doi:10.1021/acs.chemmater.9b03435

A Visualizable Test Problem Generator for Many-Objective Optimization

2022

Visualizing the search behavior of a series of points or populations in their native domain is critical in understanding biases and attractors in an optimization process. Distancebased many-objective optimization test problems have been developed to facilitate visualization of search behavior in a two-dimensional design space with arbitrarily many objective functions. Previous works have proposed a few commonly seen problem characteristics into this problem framework, such as the definition of disconnected Pareto sets and dominance resistant regions of the design space. The authors’ previous work has advanced this research further by providing a problem generator to automatically create use…