Search results for "ANSM"

Relationship between prefrontal cognitive functions and dopaminergic transmission: A [18F]-fluoro-l-DOPA PET study

2006

The expression of virulence during double infections by different parasites with conflicting host exploitation and transmission strategies

2011

In many natural populations, hosts are found to be infected by more than one parasite species. When these parasites have different host exploitation strategies and transmission modes, a conflict among them may arise. Such a conflict may reduce the success of both parasites, but could work to the benefit of the host. For example, the less-virulent parasite may protect the host against the more-virulent competitor. We examine this conflict using the waterflea Daphnia magna and two of its sympatric parasites: the blood-infecting bacterium Pasteuria ramosa that transmits horizontally and the intracellular microsporidium Octosporea bayeri that can concurrently transmit horizontally and verticall…

Differential cysteine depletion in respiratory chain complexes enables the distinction of longevity from aerobicity.

2010

Mitochondrially encoded proteins in long-lived animals exhibit a characteristic anomaly on the amino acid usage level: they abstain from the use of cysteine in a lifespan-dependent fashion. Here, we have further investigated this phenomenon by analyzing respiratory chain complex subunits individually. We find that complex I cysteine depletion is the almost exclusive carrier of the cysteine-lifespan correlation, whereas complex IV cysteine depletion is uniform in all aerobic animals, unrelated to longevity, but even more pronounced than complex I cysteine depletion in the longest-lived species. In nuclear encoded subunits of the respiratory chain, we find lifespan-independent cysteine deplet…

Iron Age craftworks in the southeast of the Iberian Peninsula. An approach based in Cultural Inheritance Theory

2021

Este trabajo tiene por objeto realizar una aproximación a las artesanías sobre materias duras de origen animal durante la Edad del Hierro en la PI y al estudio de los materiales como un medio para acercarnos a la sociedad que los produjo.  La problemática abordada contempla los procesos de la producción artesanal, la transmisión del conocimiento y la circulación de algunos de estos bienes. Hemos elegido dos tipos de piezas singulares: los peines de marfil y las placas de telar de hueso. Consideramos que este tipo de producciones constituye un fenómeno complejo y conforma una práctica cultural que recrea con códigos propios los gustos y la demanda de la época. A nivel metodológico, la Théori…

Norepinephrine transporter gene polymorphism is not associated with susceptibility to alcohol dependence

2002

Abnormalities in monoamine neurotransmission have been implicated in the pathogenesis of alcoholism, mood disorders and schizophrenia. Murine norepinephrine transporter gene (NET) has been mapped to a region on chromosome 8 where a quantitative trait locus for ethanol sensitivity. Therefore we tested whether norepinephrine transporter (NET) gene variants confer susceptibility to either alcohol dependence or severe alcohol withdrawal symptoms. There is a highly polymorphic silent G1287A mutation in the NET gene. In our study 157 alcoholics and 185 healthy unrelated matched control subjects were analyzed for a silent G1287A mutation. No significant differences in allele and genotype distribut…

Alimentary and Pharmaceutical Approach to Natural Antimicrobials against Clostridioides difficile Gastrointestinal Infection

2021

Incidence of Clostridioides difficile infection (CDI) has been increasing in recent decades due to different factors, namely (i) extended use of broad-spectrum antibiotics, (ii) transmission within asymptomatic and susceptible patients, and (iii) unbalanced gastrointestinal microbiome and collateral diseases that favor C. difficile gastrointestinal domination and toxin production. Although antibiotic therapies have resulted in successful control of CDI in the last 20 years, the development of novel strategies is urged in order to combat the capability of C. difficile to generate and acquire resistance to conventional treatments and its consequent proliferation. In this regard, vegetable and…

Transmediating argumentation : Students composing across written essays and digital videos in higher education

2016

This comparative study examined how university students built an argument in written essays and multimodal digital videos, and how their argumentation transmediated across these two mediums. Data analysis involved 1) analysis of content in both written essays and digital videos; 2) the development of transmediation visualizations to elucidate how ideas were transformed from essays into videos; and 3) multimodal analysis to understand the communicative affordances and constrains for argumentation with each medium. The findings revealed that the most common type of content in both essays and videos was supportive argumentation; however, the videos did not include any counter-argumentation. St…

Effects of muscle activation on shear between human soleus and gastrocnemius muscles

2015

Lateral connections between muscles provide pathways for myofascial force transmission. To elucidate whether these pathways have functional roles in vivo, we examined whether activation could alter the shear between the soleus (SOL) and lateral gastrocnemius (LG) muscles. We hypothesized that selective activation of LG would decrease the stretch-induced shear between LG and SOL. Eleven volunteers underwent a series of knee joint manipulations where plantar flexion force, LG, and SOL muscle fascicle lengths and relative displacement of aponeuroses between the muscles were obtained. Data during a passive full range of motion were recorded, followed by 20° knee extension stretches in both pass…

Structural and Optical Properties of Novel Surfactant Coated TiO2–Ag Based Nanoparticles

2010

Stable dispersions of surfactant-coated TiO2–Ag based nanoparticles in apolar medium have been prepared by performing sequentially the hydrolysis of titanium(IV) isopropoxide and the reduction of Ag? in the confined space of sodium bis(2-ethylhexyl)sulfosuccinate (NaAOT) reverse micelles. Depending on the sequence length, this novel procedure allowed the synthesis of semiconductor–metal nanoparticles, nominally indicated as TiO2/Ag, TiO2/Ag/TiO2, and TiO2/Ag/TiO2/ Ag, stabilized by a monolayer of oriented surfactant molecules. The structural characterization of these nanoparticles has been performed by High Resolution Transmission Electron Microscopy (HR-TEM), while optical properties were …

Candidate genetic pathways for attention-deficit/hyperactivity disorder (ADHD) show association to hyperactive/impulsive symptoms in children with AD…

2013

Item does not contain fulltext OBJECTIVE: Because multiple genes with small effect sizes are assumed to play a role in attention-deficit/hyperactivity disorder (ADHD) etiology, considering multiple variants within the same analysis likely increases the total explained phenotypic variance, thereby boosting the power of genetic studies. This study investigated whether pathway-based analysis could bring scientists closer to unraveling the biology of ADHD. METHOD: The pathway was described as a predefined gene selection based on a well-established database or literature data. Common genetic variants in pathways involved in dopamine/norepinephrine and serotonin neurotransmission and genes involv…