Search results for "AP1"
showing 9 items of 69 documents
Apoptotic-like Leishmania exploit the host´s autophagy machinery to reduce T-cell-mediated parasite elimination
2015
Apoptosis is a well-defined cellular process in which a cell dies, characterized by cell shrinkage and DNA fragmentation. In parasites like Leishmania, the process of apoptosis-like cell death has been described. Moreover upon infection, the apoptotic-like population is essential for disease development, in part by silencing host phagocytes. Nevertheless, the exact mechanism of how apoptosis in unicellular organisms may support infectivity remains unclear. Therefore we investigated the fate of apoptotic-like Leishmania parasites in human host macrophages. Our data showed--in contrast to viable parasites--that apoptotic-like parasites enter an LC3(+), autophagy-like compartment. The compartm…
Can you blame cold feet on Epac (and Rap1A)? Focus on “Cyclic AMP-Rap1A signaling activates RhoA to induce α2C-adrenoceptor translocation to the cell…
2012
Intracellular signaling by the second messenger cyclic AMP (cAMP) activates the Ras-related small GTPase Rap1 through the guanine exchange factor Epac. This activation leads to effector protein interactions, activation, and biological responses in the vasculature, including vasorelaxation. In vascular smooth muscle cells derived from human dermal arterioles (microVSM), Rap1 selectively regulates expression of G protein-coupled α2C-adrenoceptors (α2C-ARs) through JNK-c-jun nuclear signaling. The α2C-ARs are generally retained in the trans-Golgi compartment and mobilize to the cell surface and elicit vasoconstriction in response to cellular stress. The present study used human microVSM to exa…
Papel de la mitocondria en la neurodegeneración de las neuropatías periféricas
2014
La disfunción mitocondrial tiene severas consecuencias a nivel celular, y está íntimamente relacionada con el proceso de envejecimiento. Pero además, la mitocondria juega un importante papel en la muerte celular progresiva característica de algunos trastornos neurodegenerativos, de forma que la disfunción mitocondrial ha surgido como un denominador común en varias enfermedades neurodegenerativas. En la presente Tesis Doctoral nos hemos centrado en el estudio de los mecanismos patogénicos que conducen a la degeneración neuronal de dos neuropatías periféricas diferentes, pero relacionadas: ataxia de Friedreich (FRDA) y la enfermedad de Charcot-Marie-Tooth (CMT) tipos 4A/2K. Ambas enfermedades…
Regulation of Apoptosis by Inhibitors of Apoptosis (IAPs).
2013
Abstract Inhibitors of Apoptosis (IAPs) are a family of proteins with various biological functions including regulation of innate immunity and inflammation, cell proliferation, cell migration and apoptosis. They are characterized by the presence of at least one N-terminal baculoviral IAP repeat (BIR) domain involved in protein-protein interaction. Most of them also contain a C-terminal RING domain conferring an E3-ubiquitin ligase activity. In drosophila, IAPs are essential to ensure cell survival, preventing the uncontrolled activation of the apoptotic protease caspases. In mammals, IAPs can also regulate apoptosis through controlling caspase activity and caspase-activating platform format…
"Table 2" of "Investigations of anisotropic flow using multi-particle azimuthal correlations in pp, p-Pb, Xe-Xe, and Pb-Pb collisions at the LHC"
2019
$v_3\{2\}$ with $|\Delta \eta| > 1.0$ in pp collisions at $\sqrt{s} = 13$ TeV.
"Table 1" of "Investigations of anisotropic flow using multi-particle azimuthal correlations in pp, p-Pb, Xe-Xe, and Pb-Pb collisions at the LHC"
2019
$v_2\{2\}$ with $|\Delta \eta| > 1.4$ in pp collisions at $\sqrt{s} = 13$ TeV.
"Table 3" of "Investigations of anisotropic flow using multi-particle azimuthal correlations in pp, p-Pb, Xe-Xe, and Pb-Pb collisions at the LHC"
2019
$v_4\{2\}$ with $|\Delta \eta| > 1.0$ in pp collisions at $\sqrt{s} = 13$ TeV.
"Table 20" of "Investigations of anisotropic flow using multi-particle azimuthal correlations in pp, p-Pb, Xe-Xe, and Pb-Pb collisions at the LHC"
2019
$v_2\{2\}$ with $|\Delta \eta| > 1.4$ in Xe-Xe collisions at $\sqrt{s_{NN}} = 5.44$ TeV.
"Table 22" of "Investigations of anisotropic flow using multi-particle azimuthal correlations in pp, p-Pb, Xe-Xe, and Pb-Pb collisions at the LHC"
2019
$v_4\{2\}$ with $|\Delta \eta| > 1.0$ in Xe-Xe collisions at $\sqrt{s_{NN}} = 5.44$ TeV.