Search results for "APR"

MOLECULAR BASIS OF DRUG PHOTOTOXICITY: PHOTOSENSITIZED CELL DAMAGE BY THE MAJOR PHOTOPRODUCT OF TIAPROFENIC ACID

1994

Tiaprofenic acid is a photosensitizing nonsteroidal anti-inflammatory drug, whose major photoproduct (decarboxytiaprofenic acid) is also a potent photosensitizer. Because of the lack of the carboxylate moiety, this photoproduct is more lipophilic and might bind more efficiently to cell membranes, thereby causing phototoxic damage. To verify the feasibility of this hypothesis, we have prepared the 3H-labeled analogs of tiaprofenic acid and its photoproduct and examined the binding, persistence and phototoxicity of the photoproduct using poorly metabolizing (fibroblasts) and actively metabolizing cells (hepatocytes). The photoproduct of tiaprofenic acid accumulates in both cell types as it is…

Resolución supuesto práctico en el procedimiento selectivo para ingreso en el cuerpo de maestros 2018 para la Comunidad Valenciana

2021

En este documento se encuentra la resolución del supuesto práctico que se planteó en la Comunidad Valenciana durante las oposiciones del año 2018 para el cuerpo de maestros de Educación Infantil. Respondiendo al diseño de una propuesta didáctica contextualizada en los lenguajes plástico, musical y corporal. Atendiendo a la organización y espacios de la misma. Teniendo en cuenta que el centro sigue un programa de tutorización entre Educación Infantil y Primaria y una metodología basada en el Aprendizaje Basado en Proyectos. This document contains the resolution of the practical assumption that was raised in the Valencian Community during the 2018 competitive examinations for early Childhood …

Inmediato y after effects de transcraneal direct-current stimulation in mouse primary somatosensory cortex.

2021

Transcranial direct-current stimulation (tDCS) is a non-invasive brain stimulation technique consisting in the application of weak electric currents on the scalp. Although previous studies have demonstrated the clinical value of tDCS for modulating sensory, motor, and cognitive functions, there are still huge gaps in the knowledge of the underlying physiological mechanisms. To define the immediate impact as well as the after effects of tDCS on sensory processing, we first performed electrophysiological recordings in primary somatosensory cortex (S1) of alert mice during and after administration of S1-tDCS, and followed up with immunohistochemical analysis of the stimulated brain regions. Du…

Effectiveness of progestogens to improve perinatal outcome in twin pregnancies : an individual participant data meta-analysis

2015

Background In twin pregnancies, the rates of adverse perinatal outcome and subsequent long-term morbidity are substantial, and mainly result from preterm birth (PTB). Objectives To assess the effectiveness of progestogen treatment in the prevention of neonatal morbidity or PTB in twin pregnancies using individual participant data meta-analysis (IPDMA). Search strategy We searched international scientific databases, trial registration websites, and references of identified articles. Selection criteria Randomised clinical trials (RCTs) of 17–hydroxyprogesterone caproate (17Pc) or vaginally administered natural progesterone, compared with placebo or no treatment. Data collection and analysis I…

Artūrs Holitschers un viņa ceļojumu apraksti

2018

Šis bakalaura darbs apskata Artūra Holitschera ceļojumu aprakstus. Darba mērķis ir analizēt viņa biogrāfiju un ceļojumus tā laika sabiedrības un literatūras attīstības tendenču kontekstā. Pētījumā rezultātā tika secināts, ka Artūrs Holitschers ienesa nozīmīgu ieguldījumu 20. gadsimta ceļojumu aprakstos un aprakstīja ne tikai arhitektūru, plisētas un valstis, bet arī sociālās un politiskās problēmas. Kā arī ņemot par piemēru viņa darbus, tos var uzskatīt gan par reportāžām, gan par ceļojumu aprakstiem, gan par ceļvežiem. Tika konstatēts, ka ceļojumu literatūru var sadalīt divos virzienos: fikcionālie un nefikcionālie teksti.

Synthesis of monodisperse oligomers of ɛ-aminocaproic acid up to a degree of polymerization of 25 by the Merrifield method (1)

1967

Retention of aroma compounds in starch matrices: competitions between aroma compounds toward amylose and amylopectin

2002

International audience; The retention of three aroma compounds-isoamyl acetate, ethyl hexanoate, and linalool--from starch-containing model food matrices was measured by headspace analysis, under equilibrium conditions. We studied systems containing standard or waxy corn starch with one or two aroma compounds. The three studied aroma compounds interact differently: ethyl hexanoate and linalool form complexes with amylose, and isoamyl acetate cannot. However, in systems containing one aroma compound, we observed with both starches a significant retention of the three molecules. These results indicate that amylopectin could play a role in the retention of aroma. In systems containing two arom…

Photobinding of Tiaprofenic Acid and Subprofen to Proteins and Cells: A Combined Study Using Radiolabeling, Antibodies and Laser Flash Photolysis of …

1998

Drug photoallergy is a matter of current concern. It involves the formation of drug-protein photoadducts (photoantigens) that may ultimately trigger an immunological response. Tyrosine residues appear to be key binding sites in proteins. The present work has investigated the photobinding of tiaprofenic and (TPA) and the closely related isomer suprofen (SUP) to proteins and cells by means of radioactive labeling and drug-directed antibodies. To ascertain whether preassociation with the protein may play a role in photoreactivity, two model bichromophoric compounds (TPA-Tyr and SUP-Tyr) have been prepared and studied by laser flash photolysis. The results of this work show that (a) TPA and SUP…

Siboc, Chotacabras pardo (VER0000118)

Altres noms vulgars: Red-necked Nightjar (Anglès), Engoulevent à collier roux (Francès), Rothals-Ziegenmelker (Alemany) Gabinet de Vertebrats (Departament de Zoologia), Facultat de Ciències Biològiques (Campus de Burjassot), C/ Doctor Moliner, s/n, Bloque B. 5é plant, Burjassot (Valencia). Armari: 31-5 Valencia

Behavior of Flavor Compounds in Model Food Systems:  a Thermodynamic Study

2003

Physicochemical parameters, such as hydrophobicity, water solubility, and volatility, of four flavor compounds (ethyl acetate, ethyl butyrate, ethyl hexanoate, and 2-pentanone) were determined. The amount of flavor compounds released from different model matrices (mineral water, purified triolein, an oil-in-water emulsion, a carbohydrate matrix, and a complex matrix containing lipids and carbohydrates) into the gaseous phase was determined at thermodynamic equilibrium, at 37 degrees C, by static headspace gas chromatography. The degree of interaction between the flavor compounds and the matrix components was shown by measuring the percentage retention using the water matrix as the reference…