Search results for "APT"
showing 10 items of 5479 documents
Development of day-night rhythmicity in "synaptic" ribbon numbers in the pinealocytes of posthatch chicks kept under either natural photoperiodic con…
1991
: Pineal synaptic ribbons (SR) undergo characteristic changes over a period of 24 hr under natural photoperiodic conditions in various vertebrates, being low in number during daytime and elevated at night. During posthatch development of chicks, the rhythmicity of SR numbers is reported to appear at the age of about 2 weeks. Because the influence of external light during the growth phase of chicks on the development of day-night rhythmicity in SR numbers is unknown, we studied day-night differences in SR numbers in the pinealocytes of chicks at the posthatch ages of 15, 17, and 19 days; chicks had previously been kept under natural photoperiodic conditions or continuous illumination. Under …
2015
The melanocortin system is one of the most important neuronal pathways involved in the regulation of food intake and is probably the best characterized. Agouti-related peptide (AgRP) and proopiomelanocortin (POMC) expressing neurons located in the arcuate nucleus of the hypothalamus are the key elements of this system. These two neuronal populations are sensitive to circulating molecules and receive many excitatory and inhibitory inputs from various brain areas. According to sensory and metabolic information they integrate, these neurons control different aspects of feeding behavior and orchestrate autonomic responses aimed at maintaining energy homeostasis. Interestingly, composition and a…
Context dependent variation in corticosterone and phenotypic divergence of Rana arvalis populations along an acidification gradient
2022
Background Physiological processes, as immediate responses to the environment, are important mechanisms of phenotypic plasticity and can influence evolution at ecological time scales. In stressful environments, physiological stress responses of individuals are initiated and integrated via the release of hormones, such as corticosterone (CORT). In vertebrates, CORT influences energy metabolism and resource allocation to multiple fitness traits (e.g. growth and morphology) and can be an important mediator of rapid adaptation to environmental stress, such as acidification. The moor frog, Rana arvalis, shows adaptive divergence in larval life-histories and predator defense traits along an acidi…
Monitoring Training Adaptation With a Submaximal Running Test in Field Conditions
2016
Regular monitoring of adaptation to training is important for optimizing training load and recovery, which is the main factor in successful training. Purpose: To investigate the usefulness of a novel submaximal running test (SRT) in field conditions in predicting and tracking changes of endurance performance. Methods: Thirty-five endurance-trained men and women (age 20–55 y) completed the 18-wk endurance-training program. A maximal incremental running test was performed at weeks 0, 9, and 18 for determination of maximal oxygen consumption (VO2max) and running speed (RS) at exhaustion (RSpeak) and lactate thresholds (LTs). In addition, the subjects performed weekly a 3-stage SRT including a …
Factores psicosociales y de adaptación en adolescentes con enfermedad endocrina crónica y sus familias
2023
La adolescencia puede ser una etapa llena de complicaciones en las que la salud mental, el bienestar y la autoestima se vean comprometidas. Si a lo anterior se le une el hecho de tener una enfermedad no transmisible y crónica como la diabetes mellitus tipo 1 (T1DM), las dificultades pueden ser mayores. La presencia crónica de una enfermedad física afecta a todo el sistema familiar, por lo que el tipo y calidad de las interacciones entre las personas cuidadoras y el adolescente con DMT1 pueden afectar (facilitando o dificultando) el ajuste a la enfermedad de toda la familia. Existen pocos trabajos que aborden las relaciones entre la díada cuidador/a familiar principal-adolescente. El objetiv…
Ajuste psicológico en cuidadores familiares de adolescentes : un análisis longitudinal durante el confinamiento por la COVID-19 en España
2021
Resumen y palabras clave en español e inglés Resumen basado en el de la publicación Monográfico con el título: “Implicaciones psicológicas de la pandemia de COVID-19” Título del monográfico en inglés: “The psycological implications of the COVID-19 pandemic” Debido al confinamiento por la COVID-19, las familias españolas tuvieron que adaptarse a nuevas situaciones y rutinas. Se plantea conocer qué variables explicaban el ajuste psicológico de cuidadores familiares de adolescentes ante la COVID-19, mediante un estudio longitudinal (evaluando primero a las 2-3 semanas del inicio del estado de alarma y después tras 8 semanas de su instauración en España). Participaron 32 progenitores de adolesc…
MiR-33a Controls hMSCS Osteoblast Commitment Modulating the Yap/Taz Expression Through EGFR Signaling Regulation
2019
Mesenchymal stromal cells (hMSCs) display a pleiotropic function in bone regeneration. The signaling involved in osteoblast commitment is still not completely understood, and that determines the failure of current therapies being used. In our recent studies, we identified two miRNAs as regulators of hMSCs osteoblast differentiation driving hypoxia signaling and cytoskeletal reorganization. Other signalings involved in this process are epithelial to mesenchymal transition (EMT) and epidermal growth factor receptor (EGFR) signalings through the regulation of Yes-associated protein (YAP)/PDZ-binding motif (TAZ) expression. In the current study, we investigated the role of miR-33a family as a (…
Lisístrata, de Aristófanes a König
2009
En 411 a. C., Aristófanes pone en escena la comedia Lisístrata, en la que las mujeres atenienses y espartanas, hartas de la guerra del Peloponeso, idean un plan para que sus maridos dejen de luchar: una huelga de sexo. Contada desde la perspectiva femenina, Lisístrata nos muestra a las mujeres en acción en una inversión de roles cara al poeta cómico. En 1987, el historietista alemán Ralf König toma el argumento de esa comedia para brindarnos una relectura en clave homosexual: nos muestra qué ocurre entre los hombres cuando las mujeres se encierran en la acrópolis para hacer efectiva su huelga sexual. Se trata de una adaptación por demás interesante, no solo por lo que König cambia, no solo …
Transcriptional Rewiring, Adaptation, and the Role of Gene Duplication in the Metabolism of Ethanol of Saccharomyces cerevisiae
2020
Ethanol is the main by-product of yeast sugar fermentation that affects microbial growth parameters, being considered a dual molecule, a nutrient and a stressor. Previous works demonstrated that the budding yeast arose after an ancient hybridization process resulted in a tier of duplicated genes within its genome, many of them with implications in this ethanol “produce-accumulate-consume” strategy. The evolutionary link between ethanol production, consumption, and tolerance versus ploidy and stability of the hybrids is an ongoing debatable issue. The implication of ancestral duplicates in this metabolic rewiring, and how these duplicates differ transcriptionally, remains unsolved. Here, we …
Revista electrónica de investigación y evaluación educativa
2017
Resumen basado en el de la publicación Título, resumen y palabras clave en español e inglés Disponible la versión en inglés El objetivo es analizar el proyecto de nuevo cuestionario diseñado por la Universidad del País Vasco (UPV/EHU) para realizar la evaluación de sus docentes (SET). Se analizan las respuestas de una muestra de 941 estudiantes y se estudia la fiabilidad del cuestionario, la dimensionalidad, la validez de constructo y criterial, finalizando con un estudio diferencial tomando en cuenta variables como el género, el campo disciplinar, el nivel percibido de dificultad o el interés de las materias. Los resultados permiten afirmar que se trata de un instrumento de alta consistenc…