Search results for "APT"
showing 10 items of 5479 documents
Intravitreal pegaptanib for refractory macular edema secondary to retinal vein occlusion
2011
Patricia Udaondo1,2, Salvador Garcia-Delpech1,3, David Salom1,3, Maria Garcia-Pous1,3, Manuel Diaz-Llopis1,31Nuevo Hospital Universitario y Politecnico La Fe, Valencia, Spain; 2University Cardenal Herrera CEU, Valencia, Spain; 3Faculty of Medicine, University of Valencia, Valencia, SpainPurpose: To assess the efficacy of intravitreal Pegaptanib sodium (Macugen®) injection in the management of refractory macular edema secondary to branch retinal vein occlusion.Methods: This is a prospective, nonrandomized, interventional case series. Five eyes of five patients with macular edema refractory to either bevacizumab or triamcinolone were treated with intravitreal injection of Pegaptanib s…
High-resolution images in macular disorders
2021
Objective: This study analyzed and compared the results of adaptive optics (AO) and fundus autofluorescence (FAF) in various maculopathies. Methods: The study included four different types of maculopathy: central serous chorioretinopathy (CSC), retinitis pigmentosa (RP), Stargardt disease (STGD) and phototoxic retinopathy. In all four cases, cone mosaic and cone density were obtained using AO fundus camera. Further, the high-resolution images were compared with the FAF and optical coherence tomography (OCT) results. Results: In CSC, FAF and AO, changes could be shown in the macula even two years after the subretinal fluid resorption, as opposed to a normal OCT. The improvement of FAF and co…
Intravitreal Pegaptanib in Ischemic CRVO Refractory Exudative Macular Detachment
2012
Abstract Recent literature data reported evidence of the visual and/or anatomical benefits of all clinically available anti-VEGF drugs for the treatment of macular edema (ME) following Central Retinal Vein Occlusion (CRVO), up to 1-year followup. There are no randomized clinical trial data on anti-VEGF agents in ischemic CRVO-ME and the use of anti-VEGF agents to treat this condition. A 73-year old caucasian man, with a medical history of diabetes and systemic hypertension and an ophthalmic history of ischemic CRVO with cystoid macular edema was referred to our division on January 2011. The ophthalmic examination showed in right eye a visual acuity of 20/2000, a C2N1 cataract and an exudati…
Management of macular edema due to branch retinal vein occlusion with intravitreal injections of pegaptanib sodium
2009
Purpose To evaluate the efficacy of Pegaptanib Sodium as single therapy for macular edema due to non-ischemic branch retinal vein occlusion. Methods In this uncontrolled prospective pilot study 17 patients have been included with non-ischemic branch retinal vein occlusion. All of them showed macular edema in the OCT with central foveal thickness higher than 350 microns (mean, 541 +/- 140) and decrease in visual acuity lower than 0,5 Snellen ETDRS charts notation (mean, 0,16+/-0,14). After an initial injection of Pegaptanib Sodium evaluations were programmed every 5 weeks and further retreatments were developed in cases with macular thickness higher than 300 microns. No other therapies were …
Visual and postural eye-height information is flexibly coupled in the perception of virtual environments.
2021
We conducted two experiments to investigate how observers integrate postural and visual eye-height information when estimating the layout of interior space. In Experiment 1, we varied postural and visual eye-height information independently of each other in a virtual-reality setup. Observers estimated the width, depth, and height of simulated rooms. All dimensions were perceived as larger when the virtual visual eye-height corresponded to sitting on the floor as compared with standing upright. In contrast, the estimates remained widely unaffected by the observer's physical posture (likewise sitting vs. standing). In Experiment 2, we studied effects of the viewing condition (real vs. virtual…
Quantitative ultrasonography of muscle: Detection of adaptations to training in elderly women
1996
Abstract Objective: To develop quantitative ultrasonography in studying the adaptation of quadriceps muscle mass and composition to short-term physical training and rehabilitation in elderly women. Design: Randomized control trial. Setting: Measurements in a research laboratory and training in a fitness center and sports hall. Participants: Forty-two women, aged 76 to 78 years, with no indications against intensive physical exercise, randomly assigned to strength ( n = 16), endurance ( n = 15), and control ( n = 11) groups. Twelve subjects from the strength, 12 from the endurance, and 11 from the control group completed the study. Intervention: Supervised physical training 3 times a week fo…
Investigational agents for Crohn's disease.
2010
IMPORTANCE OF THE FIELD: Increased understanding of the biological mechanisms of Crohn's disease has opened the door to a large number of new molecules; some of these are approved for clinical use, while others remain under evaluation. In this review, we examine the clinical efficacy of all the new drugs that have been evaluated in controlled trials in the last 12 years. AREAS COVERED IN THIS REVIEW: Anti-TNF therapy has been reviewed briefly, given the many comprehensive reviews on this topic; attention is focused mainly on the other biological therapies. In assessing the clinical efficacy of these molecules, we consider only the remission rate, as this is considered the most meaningful en…
In vivo angiotensin I-converting enzyme inhibition by long-term intake of antihypertensive lactoferrin hydrolysate in spontaneously hypertensive rats
2013
Abstract We evaluated the effect of the long-term intake of a bovine lactoferrin hydrolysate enriched in low molecular weight peptides (LFH in vivo mechanism of action. Male spontaneously hypertensive rats received tap water (negative control), captopril (positive control, 76 mg/kg/day), LFH in vivo mechanism for the antihypertensive effect of long-term oral administration of LFH
Reactive Response and Adaptive Modifications in Dynamic Stability to Changes in Lower Limb Dynamics in the Elderly while Walking
2011
The aim of this study was to examine the reactive responses and adaptive modifications in dynamic stability resulting from a unilateral change in lower limb dynamics in older and younger adults while walking. Eleven older (62- 76yrs) and eleven younger (22-30yrs) subjects walked on a treadmill and performed different gait conditions using an external resistance against lower limb movement. The margin of stability (MoS) at touchdown was calculated as the difference between base of support (BoS) and extrapolated centre of mass. After the resistance was turned on unexpectedly, older adults needed more steps to get back to the MoS baseline level due to a lower increase of the BoS. In the follow…
Adaptation and Refinement of Validated Risk Screening Tools in the Spanish Healthcare System
2013
Abstract The aim of this study is to develop a tool to screen elders at risk of hospital readmissions adapted to Spanish target population. The development of this new tool is based on the validated instrument The Community Assessment Risk Screen – CARS –, which is being applied in a sample of 1.000 older patients. The adaptation and refinement of CARS is being carried out through the compilation of new potential variables from primary care clinicians to predict patients at risk of readmissions. The introduction of this new instrument adapted to Spanish target population will provide a potential tool to identify prematurel y patients at risk of hospital readmissions.