Search results for "ARFI"
showing 10 items of 103 documents
Reproductive strategy as a piece of the biogeographic puzzle: a case study using Antarctic sea stars (Echinodermata, Asteroidea)
2017
13 pages; International audience; AimTo describe and analyse asteroid biogeographic patterns in the Southern Ocean (SO) and test whether reproductive strategy (brooder versus broadcaster) can explain distribution patterns at the scale of the entire class. We hypothesize that brooding and broadcasting species display different biogeographic patterns.LocationSouthern Ocean, south of 45 °S.MethodsOver 14,000 asteroid occurrences are analysed using bootstrapped spanning network (BSN), non-metrical multidimensional scaling (nMDS) and clustering to uncover the spatial structure of faunal similarities among 25 bioregions.ResultsMain biogeographic patterns are congruent with previous works based on…
Iron Age craftworks in the southeast of the Iberian Peninsula. An approach based in Cultural Inheritance Theory
2021
Este trabajo tiene por objeto realizar una aproximación a las artesanías sobre materias duras de origen animal durante la Edad del Hierro en la PI y al estudio de los materiales como un medio para acercarnos a la sociedad que los produjo. La problemática abordada contempla los procesos de la producción artesanal, la transmisión del conocimiento y la circulación de algunos de estos bienes. Hemos elegido dos tipos de piezas singulares: los peines de marfil y las placas de telar de hueso. Consideramos que este tipo de producciones constituye un fenómeno complejo y conforma una práctica cultural que recrea con códigos propios los gustos y la demanda de la época. A nivel metodológico, la Théori…
A rare form of spondylometaphyseal dysplasia-type A4
1998
We present 2 cases of a previously apparently unreported spondylo-metaphyseal dysplasia comprising dwarfism, severe metaphyseal changes, ovoid vertebrae and mild platyspondyly with anterior tonguing of the vertebral bodies. The inheritance may be autosomal recessive.
Physiological advantages of dwarfing in surviving extinctions in high-CO2 oceans
2015
Excessive CO 2 in the present-day ocean-atmosphere system is causing ocean acidification, and is likely to cause a severe biodiversity decline in the future, mirroring effects in many past mass extinctions. Fossil records demonstrate that organisms surviving such events were often smaller than those before, a phenomenon called the Lilliput effect. Here, we show that two gastropod species adapted to acidified seawater at shallow-water CO 2 seeps were smaller than those found in normal pH conditions and had higher mass-specific energy consumption but significantly lower whole-animal metabolic energy demand. These physiological changes allowed the animals to maintain calcification and to parti…
Molecular mechanisms of carfilzomib-induced cardiotoxicity in mice and the emerging cardioprotective role of metformin
2019
AbstractCarfilzomib (Cfz), an irreversible proteasome inhibitor licensed for relapsed/refractory myeloma, is associated with cardiotoxicity in humans. We sought to establish the optimal protocol of Cfz-induced cardiac dysfunction, to investigate the underlying molecular-signaling and, based on the findings, to evaluate the cardioprotective potency of metformin (Met). Mice were randomized into protocols 1 and 2 (control and Cfz for 1 and 2 consecutive days, respectively); protocols 3 and 4 (control and alternate doses of Cfz for 6 and 14 days, respectively); protocols 5A and 5B (control and Cfz, intermittent doses on days 0, 1 [5A] and 0, 1, 7, and 8 [5B] for 13 days); protocols 6A and 6B (p…
Multivariate and Multiscale Complexity of Long-Range Correlated Cardiovascular and Respiratory Variability Series
2020
Assessing the dynamical complexity of biological time series represents an important topic with potential applications ranging from the characterization of physiological states and pathological conditions to the calculation of diagnostic parameters. In particular, cardiovascular time series exhibit a variability produced by different physiological control mechanisms coupled with each other, which take into account several variables and operate across multiple time scales that result in the coexistence of short term dynamics and long-range correlations. The most widely employed technique to evaluate the dynamical complexity of a time series at different time scales, the so-called multiscale …
Generalising Theories Explaining the Different Modes of SME Development and the Associated Growth Trajectories
2010
Previous research has identified two forms of “abnormal” growth – styled as business dwarfism and gigantism - which can both lead to missed opportunities for owners/entrepreneurs and local economies, and even to business crisis and collapse. It has also shown that stunted and inflated growth phenomena, rather than being characterised by completely different rules and rationales, are closely related and that certain fundamental structures and processes underpin both those forms of ab-normal company growth behaviour. This paper reports an examination of a further SME phenomenon – what we have chosen to call "micro-giants". These are companies that would be categorised as rela-tively small fir…
Adherence to growth hormone (GH) therapy in naïve to treatment GH-deficient children: data of the Italian Cohort from the Easypod Connect Observation…
2019
Background: With the use of non-objective measurement, adherence to growth hormone (GH) therapy has been reported suboptimal in a large proportion of patients, and poor adherence has been shown to affect short-term growth response in patients receiving GH treatment. Objective: The Easypod™ electronic device allows objective measurement of adherence. In this study, we report 3-year prospective adherence data of the Italian cohort of naïve GH deficient (GHD) children extrapolated from the Easypod Connect Observational Study (ECOS) database. Patients and methods: Seventy-three GHD children naïve to GH treatment were included in the analysis. 22 Italian centers participated in the study. Result…
El trabajo sobre hueso, asta y marfil en Covalta. Evidencias de un taller de época ibérica
2015
Se analizan las piezas de hueso, asta y marfil del yacimiento ibérico de Covalta desde un punto de vista tipológico, tecnológico y funcional. Se han podido documentar las distintas fases del proceso de producción de objetos terminados sobre hueso y asta, lo que nos permite señalar la existencia de un taller de fabricación de piezas sobre estas dos materias primas dentro del poblado. S'analitzen les peces d'os, banya i ivori del jaciment ibèric de Covalta des d'un punt de vista tipològic, tecnològic i funcional. S'han pogut documentar les diferents fases del procés de producció d'objectes acabats sobre os i banya, la qual cosa ens permet assenyalar l'existència d'un taller de fabricació de p…
Depth of response to isatuximab, carfilzomib, lenalidomide, and dexamethasone (Isa-KRd) in front-line treatment of high-risk multiple myeloma: Interi…
2020
8508 Background: High-risk (HR) multiple myeloma (MM) still has a significant impaired prognostic outcome. Addition of CD38 monoclonal antibodies to standard-of-care regimens significantly improved response rates and depth of response in newly diagnosed (ND) and relapsed/refractory MM patients (pts). Here, we report the prespecified end of induction interim analysis (IA) of the investigator-initiated GMMG-CONCEPT trial (NCT03104842), evaluating the quadruplet regimen isatuximab plus carfilzomib, lenalidomide and dexamethasone (Isa-KRd) in HR NDMM pts. Methods: 153 pts with HR NDMM are planned to be included into the trial. HR MM is defined by the presence of del17p or t(4;14) or t(14;16) o…