Search results for "ARM"
showing 10 items of 19046 documents
Modeling and designing a robotic swarm: A quantum computing approach
2023
Nature is a neverending source of inspiration for technology. Quantum physics suggests applications to- ward quantum computing. Swarms’ self-organization leads to robotic swarm developments. Here, quantum computing is applied to swarm robotics. We model local interactions with a quantum circuit, testing it on simulators and quantum computers. To relate local with global behavior, we develop a block matrix-based model. Diagonal sub-matrices contain information on single robots; off-diagonal sub-matrices are the pairwise interaction terms. Comparing different swarms means comparing different block matrices. Choosing initial values and computation rules for off-diagonal blocks (with a particul…
Nanorings driven by a laser field
2013
We present the dynamics of an electron constrained over an 1D ring with radius of 0.142 nm driven by a laser field. The temporal evolution of the system is evaluated by a semi-analytical solution of the full quantum time dependent Schr¨odinger equation. In our calculation the gap energy between the ground and the first excited state of the nanoring is three times the photon energy laser (0.63 eV) and the laser intensity is 4·1014 W/cm2 . Our analysis is performed by considering different polarization states of the incident laser. Our attention is mainly focused on the study of the High Harmonic Generation (HHG), the energy and the angular momentum absorbed by the driven system. We observe 1…
Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity
2011
Normal tissue damage limits the efficacy of anticancer therapy. For anthracyclines, the clinically most relevant adverse effect is cardiotoxicity. The mechanisms involved are poorly understood and putative cardioprotectants are controversially discussed. Here, we show that the lipid-lowering drug lovastatin protects rat H9c2 cardiomyoblasts from doxorubicin in vitro. Protection by lovastatin is related to inhibition of the Ras-homologous GTPase Rac1. It rests on a reduced formation of DNA double-strand breaks, resulting from the inhibition of topoisomerase II by doxorubicin. Doxorubicin transport and reactive oxygen species are not involved. Protection by lovastatin was confirmed in vivo. I…
Rac1-Regulated Endothelial Radiation Response Stimulates Extravasation and Metastasis That Can Be Blocked by HMG-CoA Reductase Inhibitors
2011
Radiotherapy (RT) plays a key role in cancer treatment. Although the benefit of ionizing radiation (IR) is well established, some findings raise the possibility that irradiation of the primary tumor not only triggers a killing response but also increases the metastatic potential of surviving tumor cells. Here we addressed the question of whether irradiation of normal cells outside of the primary tumor augments metastasis by stimulating the extravasation of circulating tumor cells. We show that IR exposure of human endothelial cells (EC), tumor cells (TC) or both increases TC-EC adhesion in vitro. IR-stimulated TC-EC adhesion was blocked by the HMG-CoA reductase inhibitor lovastatin. Glycyrr…
Racionāla antibakteriālo līdzekļu lietošana akūta nekomplicēta cistīta gadījumā
2015
Akūts nekomplicēts cistīts ir bieži sastopama infekcija, kuras ārstēšanai ir piemērotas dažādu grupu antibiotikas. Darba mērķis ir noskaidrot, vai Latvijā pacienti racionāli lieto antibiotikas urīnceļu infekciju ārstēšanai. Mērķa sasniegšanai tika veikta aptauja. Iegūtie dati liecina, ka visbiežāk urīnceļu infekcijas gadījumā pacienti lieto nitrofurantoīnu (47%), tad β-laktāma grupas antibiotikas(32%),fluorkvinolonu grupas antibiotikas (13%) un TMP/SMX kombināciju(8%). Cefalosporīnu grupas antibiotikas netika lietotas nevienā gadījumā. Pētījuma respondenti uzskata, ka racionāli lieto antibiotikas urīnceļu infekcijas ārstēšanai, tomēr rezultāti parādīja, ka ne visi ir pietiekami informēti pa…
Radial symmetry of p-harmonic minimizers
2017
"It is still not known if the radial cavitating minimizers obtained by Ball [J.M. Ball, Discontinuous equilibrium solutions and cavitation in nonlinear elasticity, Phil. Trans. R. Soc. Lond. A 306 (1982) 557--611] (and subsequently by many others) are global minimizers of any physically reasonable nonlinearly elastic energy". The quotation is from [J. Sivaloganathan and S. J. Spector, Necessary conditions for a minimum at a radial cavitating singularity in nonlinear elasticity, Ann. Inst. H. Poincare Anal. Non Lineaire 25 (2008), no. 1, 201--213] and seems to be still accurate. The model case of the $p$-harmonic energy is considered here. We prove that the planar radial minimizers are indee…
Phenolic Profiles, Antioxidant and Anti-Inflammatory Activities of Hydrodistillation Wastewaters from Five Lamiaceae Species
2022
Distillation is the most widely used method to obtain an essential oil from plant material. The biomass used in the process is returned as a solid residue together with variable amounts of water rich in water-soluble compounds, which currently are not addressed to any further application. The scope of this work was to evaluate the phytochemical composition of wastewaters coming from hydrodistillation (DWWs) of five aromatic plants belonging to the Lamiaceae family, and to assess their in vitro antioxidant and anti-inflammatory activities. The phenolic profiles of the DWWs were determined by HPLC-DAD and HPLC-ESI/MS. Free radical scavenging ability, oxygen radical antioxidant capacity and su…
IAEA Contribution to Nanosized Targeted Radiopharmaceuticals for Drug Delivery.
2022
The rapidly growing interest in the application of nanoscience in the future design of radiopharmaceuticals and the development of nanosized radiopharmaceuticals in the late 2000′s, resulted in the creation of a Coordinated Research Project (CRP) by the International Atomic Energy Agency (IAEA) in 2014. This CRP entitled ‘Nanosized delivery systems for radiopharmaceuticals’ involved a team of expert scientist from various member states. This team of scientists worked on a number of cutting-edge areas of nanoscience with a focus on developing well-defined, highly effective and site-specific delivery systems of radiopharmaceuticals. Specifically, focus areas of various teams of scientists com…
Radiolabeling of Nanoparticles and Polymers for PET Imaging
2014
Nanomedicine has become an emerging field in imaging and therapy of malignancies. Nanodimensional drug delivery systems have already been used in the clinic, as carriers for sensitive chemotherapeutics or highly toxic substances. In addition, those nanodimensional structures are further able to carry and deliver radionuclides. In the development process, non-invasive imaging by means of positron emission tomography (PET) represents an ideal tool for investigations of pharmacological profiles and to find the optimal nanodimensional architecture of the aimed-at drug delivery system. Furthermore, in a personalized therapy approach, molecular imaging modalities are essential for patient screeni…
Uz vēža šūnām mērķēti alfa daļiņu emiteri, jauna kompleksējoša savienojuma sintēzes metodes izstrāde
2015
Vēzis ir viena no mūsdienu medicīnas svarīgākajām problēmām. Mērķēta alfa-terapija, kas izmanto pie bioloģiskiem nesējiem piesaistītus α-daļiņas emitējošus radionuklīdus un tiek mērķēta selektīvi uz malignajām šūnām, ir veids, kā iznīcināt atsevišķas vēža šūnas, pat ja tās ir izkaisītas pa visu organismu. Šī darba mērķis ir apkopot informāciju par α-emiteru izmantošanu onkoterapijā, kā arī akcentēt galvenos farmācijas un ķīmijas saskares punktus uz audzēja šūnām mērķētu radiofarmaceitisko vielu izstrādē. Darba teorētiskajā daļā apkopota zinātniskajā literatūrā pieejamā informācija par α emiteriem, to pieejamību, darbības principu, priekšrocībām un potenciālajām iespējām onkoterapijā. Sniegt…