Search results for "ARTICLES"

LIPID AND POLYMERIC NANOSTRUCTURES FOR BRAIN DRUG DELIVERY AND TARGETING

2009

Galactosylated Polymer/Gold Nanorods Nanocomposites for Sustained and Pulsed Chemo-Photothermal Treatments of Hepatocarcinoma

2022

In this paper, we propose a rational design of a hybrid nanosystem capable of locally delivering a high amount of hydrophobic anticancer drugs (sorafenib or lenvatinib) and heat (hyperthermia) in a remote-controlled manner. We combined in a unique nanosystem the excellent NIR photothermal conversion of gold nanorods (AuNRs) with the ability of a specially designed galactosylated amphiphilic graft copolymer (PHEA-g-BIB-pButMA-g-PEG-GAL) able to recognize hepatic cells overexpressing the asialoglycoprotein receptor (ASGPR) on their membranes, thus giving rise to a smart composite nanosystem for the NIR-triggered chemo-phototherapy of hepatocarcinoma. In order to allow the internalization of A…

LIPID NANOPARTICLES AS CARRIERS FOR TARGETED RELEASE OF RILUZOLE INTO THE CENTRAL NERVOUS SYSTEM

2009

LIPID NANOPARTICLE SYSTEMS CONTAINING CURCUMIN: PREPARATION AND CHARACTERIZATION

2008

FERULIC ACID LOADED SOLID LIPID NANOPARTICLES PROTECTS LAN5 NEUROBLASTOMA CELL LINE BY Ab-AMYLOID OXIDATIVE STRESS

2008

Lipid nanocarrier for the treatment of hepatocellular carcinoma

2013

Hepatocellular carcinoma (HCC) is the sixth most prevalent cancer and the third most frequent cause of cancer-related death. Unlike most solid tumors the incidence and mortality of HCC have increased in the United States and Europe in the past decade. Most patients are diagnosed at advanced stages, so there is an urgent need for new systemic therapies [1,2]. To improve the delivery of therapeutic agents to tumor cells in vivo it’s necessary to overcome several problems, such as drug resistance at the tumor level due to physiological barriers (non cellular based mechanism), drug resistance at the cellular level (cellular mechanism), drug distribution, biotransformation and clearance of antic…

Synthesis of luminescent glass monoliths embedding water-soluble Carbon dots

2014

Carbon dots (CD) are an emerging class of nanomaterials, currently motivating an intense scientific interest because of their bright and characteristically tunable fluorescence, and their possible applications such as sensors, lasers, imaging agents, white light emitting devices [1]. While most studies focused on CDs in liquid phase, a strong effort is being recently devoted to produce fluorescent solids embedding highly dispersed CDs. Many of these procedures are elaborate and require pre-functionalization of the dots [2]. Here we report a novel and very facile route to prepare glass monoliths containing CDs with no need of pre-functionalization of the dots. Our low-cost synthesis method p…

Josephson-junction-based axion detection through resonant activation

2022

We discuss the resonant activation phenomenon on a Josephson junction due to the coupling of the Josephson system with axions. We show how such an effect can be exploited for axion detection. A nonmonotonic behavior, with a minimum, of the mean switching time from the superconducting to the resistive state versus the ratio of the axion energy and the Josephson plasma energy is found. We demonstrate how variations in switching times make it possible to detect the presence of the axion field. An experimental protocol for observing axions through their coupling with a Josephson system is proposed.

A spatially homogeneous mathematical model of immune cancer competition

2015

This paper deals with the modeling of interactions between the immune system and cancer cells, in the framework of the mathematical kinetic theory for active particles. The model assumes spatial homogeneity and continue values of the activity of cancer and immune cells.

$N$ identical particles and one particle to entangle them all

2017

In quantum information W states are a central class of multipartite entangled states because of their robustness against noise and use in many quantum processes. Their generation however remains a demanding task whose difficulty increases with the number of particles. We report a simple scalable conceptual scheme where a single particle in an ancilla mode works as entanglement catalyst of W state for other $N$ separated identical particles. A crucial novel aspect of the scheme, which exploits basically spatial indistinguishability, is its universality, being applicable without essential changes to both bosons and fermions. Our proposal represents a new paradigm within experimental preparati…