Search results for "ARTICLES"
showing 10 items of 9626 documents
Segregation in Drying Binary Colloidal Droplets
2019
When a colloidal suspension droplet evaporates from a solid surface, it leaves a characteristic deposit in the contact region. These deposits are common and important for many applications in printing, coating, or washing. By the use of superamphiphobic surfaces as a substrate, the contact area can be reduced so that evaporation is almost radially symmetric. While drying, the droplets maintain a nearly perfect spherical shape. Here, we exploit this phenomenon to fabricate supraparticles from bidisperse colloidal aqueous suspensions. The supraparticles have a core-shell morphology. The outer region is predominantly occupied by small colloids, forming a close-packed crystalline structure. Tow…
Magnetic separation of encapsulated islet cells labeled with superparamagnetic iron oxide nano particles.
2012
Islet cell transplantation is a promising option for the restoration of normal glucose homeostasis in patients with type 1 diabetes. Because graft volume is a crucial issue in islet transplantations for patients with diabetes, we evaluated a new method for increasing functional tissue yield in xenogeneic grafts of encapsulated islets. Islets were labeled with three different superparamagnetic iron oxide nano particles (SPIONs; dextran-coated SPION, siloxane-coated SPION, and heparin-coated SPION). Magnetic separation was performed to separate encapsulated islets from the empty capsules, and cell viability and function were tested. Islets labeled with 1000 μg Fe/ml dextran-coated SPIONs expe…
Inhibition of TSH/IGF-1 Receptor Crosstalk by Teprotumumab as a Treatment Modality of Thyroid Eye Disease
2021
Abstract Context We previously presented evidence that TSH receptor (TSHR)-stimulating autoantibodies (TSAbs) bind to and activate TSHRs but do not bind to IGF1 receptors (IGF1Rs). Nevertheless, we showed that IGF1Rs were involved in thyroid eye disease (TED) pathogenesis because TSAbs activated crosstalk between TSHR and IGF1R. Teprotumumab, originally generated to inhibit IGF1 binding to IGF1R, was recently approved for the treatment of TED (Tepezza). Objective To investigate the role of TSHR/IGF1R crosstalk in teprotumumab treatment of TED. Design We used orbital fibroblasts from patients with TED (TEDOFs) and measured stimulated hyaluronan (HA) secretion as a measure of orbital fibrobla…
A Single-Center Experience on Below-The-Knee Endovascular Treatment in Diabetic Patients
2020
Diabetic ulceration of the foot is a major global medical, social and economic problem and is the most frequent end-point of diabetic complications. A retrospective analysis from February 2017 to May 2019 of diabetic patients presenting below-the-knee artery disease (PAD) was carried out. Only patients treated with endovascular techniques as first choice treatment were evaluated. Outcome measured was perioperative mortality and morbidity. Freedom from occlusion, secondary patency and amputation rate were all registered. Additional maneuvers including stenting or angioplasty with drug eluting balloon (DEB) were reported. A total of 167 (101 male/66 female) patients with a mean age of 71 year…
Treatment of de novo femoro-popliteal lesions with a new Drug Coated Balloon: early experience of a single Center in the first 50 patients
2018
Angioplasty with drug-coated balloon (DCB) is an emerging and reliable method for the treatment of femoro-popliteal lesions. We report our experience with the Stellarex™ DCB in the first 50 patients. Methods - From July 2015 to November 2017, 50 patients (41 M, 9F), medium age (64 ± 7.4 year) were subject to 33 angioplasties (PTAs) for femoro-popliteal lesions with a paclitaxel-coated balloon (Stellarex™). Based upon clinical data sixteen patients had severe claudication (56% - Rutherford class 3); ten patients suffered from ischemic rest pain (34% - Rutherford class 4); and five presented minor tissue loss (10% - Rutherford class 5). 42% of patients showed femoro-popliteal lesion TASC-II B…
The Large Hadron–Electron Collider at the HL-LHC
2021
The Large Hadron-Electron Collider (LHeC) is designed to move the field of deep inelastic scattering (DIS) to the energy and intensity frontier of particle physics. Exploiting energy-recovery technology, it collides a novel, intense electron beam with a proton or ion beam from the High-Luminosity Large Hadron Collider (HL-LHC). The accelerator and interaction region are designed for concurrent electron-proton and proton-proton operations. This report represents an update to the LHeC's conceptual design report (CDR), published in 2012. It comprises new results on the parton structure of the proton and heavier nuclei, QCD dynamics, and electroweak and top-quark physics. It is shown how the LH…
Reconfigurable DNA Origami Nanocapsule for pH-Controlled Encapsulation and Display of Cargo
2019
DNA nanotechnology provides a toolbox for creating custom and precise nanostructures with nanometer-level accuracy. These nano-objects are often static by nature and serve as versatile templates for assembling various molecular components in a user-defined way. In addition to the static structures, the intrinsic programmability of DNA nanostructures allows the design of dynamic devices that can perform predefined tasks when triggered with external stimuli, such as drug delivery vehicles whose cargo display or release can be triggered with a specified physical or chemical cue in the biological environment. Here, we present a DNA origami nanocapsule that can be loaded with cargo and reversibl…
Comparative environmental analysis of soil sampling methods in precision agriculture for lime application in Paraná State, Brazil
2020
Precision agriculture (PA) provides techniques that favour the localized application of inputs allowing their rational use. This makes the PA a potential indicator of reduced operational costs, input volume, and environmental impacts. The objective of this study was to evaluate and compare the environmental effects of three different sampling methods used in PA for the lime application. The first sampling method evaluated was the grid sampling (GS). It was performed at a density of one sample per hectare in a 100×100 m georeferenced grid. The second method was the directed sampling, that was performed after defining the management zones by soil apparent electrical conductivity (ECa) using a…
Content and form in English business abstracts and research articles: a corpus-based genre approach
2012
Se han escrito muchos trabajos sobre el resumen y el artículo de investigación, especialmente en los últimos veinte años, aunque pocos dedicados al estudio de estos géneros en el ámbito empresarial, y menos en lo que se refiere a su estructura y a la relación entre ambos. El objetivo principal de este estudio es precisamente incrementar la concienciación y conocimiento de la importancia de escribir buenos resúmenes y artículos de investigación en el ámbito de los negocios y cómo el resumen debe persuadir al lector para que lea el artículo. El artículo de investigación como género ha sido objeto de estudio durante mucho tiempo, siendo reconocido su importante papel en la diseminación del con…
“Is This an Advertisement or a Personal Account?” : Commercialisation of Lifestyle Blogs in Finland
2015
When blogging first appeared on the map of social media in the mid-1990s, the majority of bloggers were male writing for example about the developments of the online world, or if they were political reporters, looking for a new platform to publish their perhaps more controversial work. Today many blogs fall into the category of lifestyle blogs, which have thousands, sometimes even tens of thousands of individual readers per month throughout the world. In fact, professional blogging is one of the fastest growing phenomena online. It is driven mostly by relatively young women and promoted by the commercialisation of the blogging world, also known by bloggers as “the blogosphere”. During the p…