Search results for "ARTICLES"

Modeling cost-effectiveness and health gains of a “universal” versus “prioritized” hepatitis C virus treatment policy in a real-life cohort

2017

We evaluated the cost-effectiveness of two alternative direct-acting antiviral (DAA) treatment policies in a real-life cohort of hepatitis C virus–infected patients: policy 1, “universal,” treat all patients, regardless of fibrosis stage; policy 2, treat only “prioritized” patients, delay treatment of the remaining patients until reaching stage F3. A liver disease progression Markov model, which used a lifetime horizon and health care system perspective, was applied to the PITER cohort (representative of Italian hepatitis C virus–infected patients in care). Specifically, 8,125 patients naive to DAA treatment, without clinical, sociodemographic, or insurance restrictions, were us…

Delivery of shRNA plasmid DNA by cationic solid lipid nanoparticles for gene silencing in human hepatocarcinoma cells

2015

Cationic Solid Lipid Nanoparticles (SLN) for shNupr1 plasmid delivery in the treatment of hepatocellular carcinoma (HCC)

2016

Review of Particle Physics

2020

The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 2,143 new measurements from 709 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and baryons. We summarize searches for hypothetical particles such as supersymmetric particles, heavy bosons, axions, dark photons, etc. Particle properties and search limits are listed in Summary Tables. We give numerous tables, figures, formulae, and reviews of topics such as Higgs Boson Physics, Supersymmetry, Grand Unified Theories, Neutrino Mixing, Dark Energy, Dark Matter, Cosmology, Particle Detectors, Colliders, …

Measurement of the top quark pair production cross-section with ATLAS in the single lepton channel

2012

A measurement of the production cross-section for top quark pairs (t[bar over t]) in pp collisions at √s = 7 TeV is presented using data recorded with the ATLAS detector at the Large Hadron Collider. Events are selected in the single lepton topology by requiring an electron or muon, large missing transverse momentum and at least three jets. With a data sample of 35 pb[superscript −1], two different multivariate methods, one of which uses b-quark jet identification while the other does not, use kinematic variables to obtain cross-section measurements of σ[subscript t bar over t] = 187 ± 11 (stat.) [+18 over −17] (syst.) ± 6 (lumi.) pb and σ[subscript t bar over t] = 173 ± 17 (stat.) [+18 ove…

SEU characterization of commercial and custom-designed SRAMs based on 90 nm technology and below

2020

International audience; The R2E project at CERN has tested a few commercial SRAMs and a custom-designed SRAM, whose data are complementary to various scientific publications. The experimental data include low- and high-energy protons, heavy ions, thermal, intermediate- and high-energy neutrons, high-energy electrons and high-energy pions.

Influence of a Cu–zirconia interface structure on CO2 adsorption and activation

2021

CO2 adsorption and activation on a catalyst are key elementary steps for CO2 conversion to various valuable products. In the present computational study, we screened different Cu–ZrO2 interface structures and analyzed the influence of the interface structure on CO2 binding strength using density functional theory calculations. Our results demonstrate that a Cu nanorod favors one position on both tetragonal and monoclinic ZrO2 surfaces, where the bottom Cu atoms are placed close to the lattice oxygens. In agreement with previous calculations, we find that CO2 prefers a bent bidentate configuration at the Cu–ZrO2 interface and the molecule is clearly activated being negatively charged. Strain…

Social, health and rehabilitation sector educators’ competence in evidence-based practice : A cross-sectional study

2021

Aim: The purpose of the study was to identify and describe the characteristic profiles of evidence-based practice competence of educators in the social, health and rehabilitation sectors and to establish relevant background factors. Design: This study was carried out as a descriptive cross-sectional study. Methods: Data were collected from social, health and rehabilitation sector educators working in the 21 Finnish universities of applied sciences and seven vocational colleges (n = 422; N = 2,330). A self-assessment instrument measuring evidence-based practice competence was used. Competence profiles were formed using a K-cluster grouping analysis. Results: Three distinct competence profile…

Metallic nanoparticles exhibit paradoxical effects on oxidative stress and pro-inflammatory response in endothelial cells in vitro

2007

Particulate matter is associated with different human diseases affecting organs such as the respiratory and cardiovascular systems. Very small particles (nanoparticles) have been shown to be rapidly internalized into the body. Since the sites of internalization and the location of the detected particles are often far apart, a distribution via the blood stream must have occurred. Thus, endothelial cells, which line the inner surface of blood vessels, must have had direct contact with the particles. In this study we tested the effects of metallic nanoparticles (Co and Ni) on oxidative stress and proinflammatory response in human endothelial cells in vitro. Exposure to both nanoparticle types…

Physical-chemical properties and possible applications of clay minerals and humic acid composite materials

2019

Article Pollution caused by pharmaceuticals has become an increasingly serious issue, therefore innovative and cost – effective methods of pharmaceutical’s removal must be studied. Clay – humic acid composite materials can be considered as prospective and low cost sorbents for contaminants. The aim of this study is to develop clay mineral and humic acid composite materials and to characterise their possible applications. For this research, three types of clay minerals (montmorillonite, kaolinite and bentonite) were modified with three types of humic substances: technical humic acid from lignite, humic substances extracted from raised bog peat and technical K humate from lignite. The sorptio…