Search results for "ASIS"
showing 10 items of 4190 documents
A misleading infection in a psoriatic patient: a challenging diagnosis of orocutaneous leishmaniasis
2019
Caracterización del efecto de los medicamentos biológicos sobre las fases iniciales de la formación de un trombo en pacientes con psoriasis
2022
La psoriasis es una enfermedad inflamatoria crónica inmunomediada, considerada una de las pocas enfermedades no transmisibles que la OMS ha identificado como un importante problema de salud. En los últimos años se ha evidenciado la existencia de una relación entre la psoriasis moderada-grave y el riesgo aumentado de sufrir enfermedades cardiovasculares (CV), considerándola en la mayoría de estudios como un factor de riesgo CV independiente de los factores tradicionales. Los mecanismos subyacentes detrás del aumento del riesgo CV no están claros, pero la alta prevalencia de aterosclerosis en estos pacientes, son consistentes con una condición inflamatoria que podría ser el inicio del puente …
Complement C5 but not C3 is expendable for tissue factor activation by cofactor-independent antiphospholipid antibodies
2018
The complement and coagulation cascades interact at multiple levels in thrombosis and inflammatory diseases. In venous thrombosis, complement factor 3 (C3) is crucial for platelet and tissue factor (TF) procoagulant activation dependent on protein disulfide isomerase (PDI). Furthermore, C5 selectively contributes to the exposure of leukocyte procoagulant phosphatidylserine (PS), which is a prerequisite for rapid activation of monocyte TF and fibrin formation in thrombosis. Here, we show that monoclonal cofactor-independent antiphospholipid antibodies (aPLs) rapidly activate TF on myelomonocytic cells. TF activation is blocked by PDI inhibitor and an anti-TF antibody interfering with PDI bin…
The iron-regulatory hormone hepcidin: A possible therapeutic target?
2015
The maintenance of stable extracellular and intracellular iron concentrations requires the coordinated regulation of iron transport into plasma. Iron is a fundamental cofactor for several enzymes involved in oxidation-reduction reactions. The redox ability of iron can lead to the production of oxygen free radicals, which can damage various cellular components. Therefore, the appropriate regulation of systemic iron homeostasis is decisive in vital processes. Hepcidin has emerged as the central regulatory molecule of systemic iron homeostasis. It is synthesized in hepatocytes and in other cells and released into the circulation. It inhibits the release of iron from enterocytes of the duodenum…
Motivos por los que los emigrantes españoles se inscriben en el registro consular
2018
La inscripción en el registro consular no es obligatoria para los emigrantes españoles. Conlleva, no obstante, una serie de ventajas que propician, antes o después, su realización. En este artículo se identifican y analizan los principales motivos que animan a ello a los emigrantes españoles. Se toman como base fundamental los datos e informaciones obtenidos a través de una encuesta cuantitativa y entrevistas semiestructuradas realizadas a más de cuatro mil españoles residentes en el extranjero. Se concluye que los principales motivos para llevar a cabo esta inscripción son los relacionados con el ejercicio de derechos y deberes ciudadanos (especialmente el de sufragio en elecciones español…
Leishmaniasis, contact hypersensitivity and graft-versus-host disease: understanding the role of dendritic cell subsets in balancing skin immunity an…
2010
Dendritic cells (DC) are key elements of the immune system. In peripheral tissues, they function as sentinels taking up and processing antigens. After migration to the draining lymph nodes, the DC either present antigenic peptides by themselves or transfer them to lymph node-resident DC. The skin is the primary interface between the body and the environment and host's various DC subsets, including dermal DC (dDC) and Langerhans cells (LC). Because of their anatomical position in the epidermis, LC are believed to be responsible for induction of adaptive cutaneous immune responses. The functions of LC and dDC in the skin immune system in vivo are manifold, and it is still discussed controvers…
Prognostic Relevance of CCN3 in Bone Sarcomas
2010
Osteosarcomas and Ewing’s sarcoma (EWS) are aggressive malignant bone tumors. In both cases, prognostic markers are lacking. Presently, only clinical features are widely accepted as prognostic indicators. In this study we assessed the prognostic value of CCN3 (Nov), a matricellular protein that belong to the CCN family of regulatory proteins, whose members were shown to play crucial roles in bone formation. In osteosarcomas, CCN3 expression levels represent a useful tool to early identification of patients with different prognosis. In both osteosarcomas and Ewing’s sarcomas, the expression of a full length CCN3 protein was associated to a worse prognostic and a higher risk to developing met…
Kritiikin lupaus : näkökulmia Frankfurtin koulun kriittiseen teoriaan
1998
Two Kings : Martin Luther Kingin postuumi julkisuuskuva ja siihen liittyneet kiistat New York Timesin ja The Washington Postin sivuilla vuosina 1970-…
2014
Työni tavoitteena oli tarkastella Martin Luther Kingin postuumia julkisuuskuvaa New York Timesin ja The Washington Postin sivuilla käydyn julkisen keskustelun perusteella. Tutkielmassa selvitän kuinka eri ihmiset Martin Luther Kingin näkivät, millaisena King kuvailtiin ja vaikuttiko kuvauksiin henkilöiden taustat? King saattoi tarkoittaa eri ihmisille eri asioita, riippuen henkilön taustasta. Esimerkiksi republikaaneille King oli monesti kansakunnan moraalinen ääni, kun taas kansalaisoikeusaktiivit halusivat Kingiä kuvailtavan pikemminkin tummaihoisten oikeuksien puolustajana, sekä radikaalina yhteiskunnan epäkohtien vastustajana. Lisäksi Martin Luther Kingin julkisuuskuvassa korostuivat ti…
Sociolinguistic upsets and people of color in social media performances
2022
Abstract Particularly since the refugee “reception crisis” in 2015, Finland has started transforming into a more diverse and multicultural society. These societal changes have also been accompanied by sociolinguistic change, as well as language ideological debates and tensions, often manifesting in explicitly racist and xenophobic bursts of upset. In this article, our focus is on social media as a space where such societal and sociolinguistic upsets are articulated and re-worked. Drawing on recent sociolinguistic and discourse analytic work on transformative and critical popular cultural practices in social media, and studies on rap and belonging, we discuss how, in a mediatized society suc…