Search results for "ASIS"
showing 10 items of 4190 documents
The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress.
2021
Summary: Chromatin organization plays a crucial role in tissue homeostasis. Heterochromatin relaxation and consequent unscheduled mobilization of transposable elements (TEs) are emerging as key contributors of aging and aging-related pathologies, including Alzheimer’s disease (AD) and cancer. However, the mechanisms governing heterochromatin maintenance or its relaxation in pathological conditions remain poorly understood. Here we show that PIN1, the only phosphorylation-specific cis/trans prolyl isomerase, whose loss is associated with premature aging and AD, is essential to preserve heterochromatin. We demonstrate that this PIN1 function is conserved from Drosophila to humans and prevents…
Impressive objective response to nab-paclitaxel plus trastuzumab as fifth line therapy in aelderly her2-positive breast cancer patient
2020
Agent targeting HER-2 pathway plus chemotherapy has represented a major progress in the management of patients with breast cancer. However the role of late-line treatment in heavily pretreated patients is largely unclear. In the last decade nab-paclitaxel has show significant activity and good toxicity profile in metastatic breast cancer. We report the case of a 76-year-old Caucasian woman with metastatic HER-2 positive ductal infiltrating breast carcinoma treated with a combination of weekly nab-paclitaxel and trastuzumab as fifth-line therapy. She had previously received first-line paclitaxel and trastuzumab, second-line vinorelbine and trastuzumab, third-line TDM1 and fourth-line oral ca…
Psoriasis and Its Impact on In-Hospital Outcome in Patients Hospitalized with Acute Kidney Injury
2020
Background: Psoriasis is a chronic inflammatory disease which affects the body far beyond the skin. Whereas there is solid evidence that chronic skin inflammation in psoriasis drives cardiovascular disease, the impact on renal impairment and acute kidney injury (AKI) is still unclear. We aimed to analyze the impact of psoriasis on the in-hospital outcome of patients hospitalized with AKI. Methods: In this retrospective database study, we investigated data on characteristics, comorbidities, and in-hospital outcomes for all hospitalized patients with AKI stratified for concomitant psoriasis, which were collected by the Federal Office of Statistics in Germany between 2005 and 2016. Results: Am…
Types, triggers and treatment strategies of psoriasis
2013
Psoriasis is a common chronic, immune mediated, inflammatory disease,characterized by periods of exacerbation and remission. Patients with psoriasis have asignificantly impaired quality of life; the disease is associated with substantial burden interms of disability or psychosocial stigmatization. Moreover, in a percentage of patientsthat varies between 5% and 42%, depending on the population studied, psoriatic arthritismay occur.Psoriasis is found worldwide but the prevalence varies among different ethnicgroups. It has a strong genetic component but environmental factors such as ß-haemolyticstreptococcal infection, HIV, stress, and drugs, including ß blockers, antimalarials andlithium can …
Transmisión congénita de la Tripanosomiasis Americana en Santa Cruz de la Sierra, Bolivia
2017
La enfermedad de Chagas o tripanosomiasis americana es una antropozoonosis endémica de América Latina, que se extiende desde el sur de EE.UU. y México, en su límite norte, hasta Argentina y Chile por el sur. Las políticas de control realizadas en áreas endémicas han llevado a reducir considerablemente la transmisión vectorial, que se ha traducido en un notable cambio en su epidemiología. La enfermedad de Chagas en Bolivia tiene los indicadores epidemiológicos básicos más elevados de América. La infección congénita es actualmente una de las más importantes vías de transmisión del T. cruzi y una de las responsables de la urbanización de la enfermedad y de su aparición en áreas alejadas de las…
Prevalencia de la enfermedad de Chagas en donantes y en mujeres embarazadas procedentes de Latinoamérica: estudio epidemiológico
2021
El objetivo de la tesis fue conocer la prevalencia de la enfe5rmedad de Chagas en población de riesgo de ambos sexos procedentes de Latinoamérica y la incidencia de la transmisión vertical (Chagas congénito en los bebés nacidos de mujeres diagnosticadas durante el periodo de estudio. Se diseñó un estudio epidemiológico transversal, descriptivo, con dos cohortes poblacionales (donantes de sangre y mujeres embarazadas) y dos fases temporales, una prospectiva (2006-2010) y otra retrospectiva (2011-2015. Los datos demográficos básicos y los resultados sobre el diagnóstico de la enfermedad de Chagas fueron facilitados por los laboratorios de los centros participantes en el estudio (Centro de tra…
Dipeptidyl Enoates As Potent Rhodesain Inhibitors That Display a Dual Mode of Action
2015
Dipeptidyl enoates were prepared through a high-yielding two-step synthetic route. They have a dipeptidic structure with a 4-oxoenoate moiety as a warhead with multiple reactive sites. Dipeptidyl enoates were screened against rhodesain and human cathepsins B and L, and were found to be potent and selective inhibitors of rhodesain. Among them (S,E)-ethyl 5-((S)-2-{[(benzyloxy)carbonyl]amino}-3-phenylpropanamido)-7-methyl-4-oxooct-2-enoate (6) was the most potent, with an IC50 value of 16.4 nm and kinact/Ki=1.6×106 m−1 s−1 against rhodesain. These dipeptidyl enoates display a reversible mode of inhibition at very low concentrations and an irreversible mode at higher concentrations. Inhibition…
Mast cells as protectors of health.
2019
Mast cells (MCs), which are well known for their effector functions in T(H)2-skewed allergic and also autoimmune inflammation, have become increasingly acknowledged for their role in protection of health. It is now clear that they are also key modulators of immune responses at interface organs, such as the skin or gut. MCs can prime tissues for adequate inflammatory responses and cooperate with dendritic cells in T-cell activation. They also regulate harmful immune responses in trauma and help to successfully orchestrate pregnancy. This review focuses on the beneficial effects of MCs on tissue homeostasis and elimination of toxins or venoms. MCs can enhance pathogen clearance in many bacter…
Eri väriä - samaa maata : ulkomaalaistaustaiset suomalaiset ja rasismi
2007
Ordered fuzzy rules generation based on incremental dataset
2021
This paper proposes a novel approach for building transparent knowledge-based systems by generating interpretable fuzzy rules that allow for present dependences between quantitative variables by accounting for uncertainty and the dynamics of their values. In the approach, IF-THEN rules are used to show the conditional relationship between the ordered fuzzy numbers, which contain additional information about the tendencies of variables' value changes. This paper elaborates an approach of mining ordered fuzzy rules from numerical data included in an incremental database. This approach develops the ability to record uncertainty and its change in the context of rapidly changing data. In additio…